Kształtowanie się metabolitów kaskady kwasu arachidonowego w warunkach gorączki endotoksynowej i tolerancji pirogenowej u gołębi

• Autorzy: Dudek K. , Bednarek D. , Studzinski T.

Warianty tytułu

EN

Alternation of metabolites of arachidonic acid cascade in the conditions of endotoxin fever and pyrogenic tolerance in pigeons

• Języki publikacji: PL

Abstrakty

EN

The aim of the study was to evaluate the changes in selected metabolites of arachidonic acid under the conditions of endotoxin fever and pyrogenic tolerance in pigeons. On the first day of the study experimental birds (n = 18) were intravenously injected with Escherichia coli LPS at a dose of 10 µg/kg b.w. (endotoxin fever induction), whereas at the same time the controls with sterile physiological saline. On the second and the third days of the study, in the pigeons previously injected with LPS the state of pyrogenic tolerance was evoked. For this purpose, on the second day twelve birds from experimental group received E. coli LPS again (10 µg/kg b.w.). On the third day of the study six from twelve experimental birds were injected with a consecutive, final dose of endotoxin. Each four-and-a-half hours after consecutive LPS injections, blood samples were collected for laboratory examinations. Prostaglandin (PGE₂ and PGF₂α), leukotrien B4 (LTB₄) and tromboxan B2 (TXB₂) concentrations were investigated in the blood sera. In response to the single LPS injection a distinct stimulation of the PGE₂ and PGF₂α synthesis was observed, which probably shows a participation of these eicosanoids in the induction of fever in the pigeons. There was also observed an increase in the LTB₄ production, an important chemotactic factor for leukocytes and a decrease in the TXB₂ concentration, which may be associated with its participation in a disseminated intravascular coagulation (DIC) visibly enhanced during endotoxemia. However consecutive LPS injections caused a distinct suppression of PGE₂ and PGF2α synthesis, and an increase in the TXB₂ concentration, probably resulting from a lysis and then resorption of endovascular blood clots composed of thrombocytes. The LTB₄ concentration was still rising in the conditions of pyrogenic tolerance, possibly indicating a strong activation of phagocytic blood cells of which a direct consequence is usually an increased migration of these cells to places with inflammatory processes and an activation their killing ability.

Słowa kluczowe

PL

ptaki; golebie; goraczka; goraczka endotoksynowa; patogeneza; eikozanoidy; tolerancja pirogenowa; odpowiedz zapalna

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2015
• Tom: 71
• Numer: 10
• Opis fizyczny: s.643-647,tab.,bibliogr.

Twórcy

autor

Dudek K.

• Zakład Chorób Bydła i Owiec, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy w Puławach, Al. Partyzantów 57, 24-100 Puławy

autor

Bednarek D.

• Zakład Chorób Bydła i Owiec, Państwowy Instytut Weterynaryjny - Państwowy Instytut Badawczy w Puławach, Al. Partyzantów 57, 24-100 Puławy

autor

Studzinski T.

• Wyższa Szkoła Humanistyczno-Przyrodnicza w Sandomierzu, ul. Krakowska 26, 27-600 Sandomierz
• Katedra Fizjologii Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul. Akademicka 13, 20-950 Lublin

Bibliografia

• 1. Akgül A., Artunkal A. A., Marley E., Stephenson J. D.: Some effects of prostaglandins E₁ and E₂ and of endotoxin injected into the hypothalamus of young chicks: dissociation between endotoxin fever and the effects of prostaglandins. Br. J. Pharmacol. 1977, 61, 39-46.
• 2. Artunkal A. A., Marley E., Stephenson J. D.: Some effects of intravenous prostaglandin E, and endotoxin in young chickens. Br. J. Pharmacol. 1977, 61, 29-37.
• 3. Baert K., De Boever S., Duchateau L., De Backer P.: Sodium salicylate attenuates lipopolysaccharide (LPS)-induced adipsia, but not hypophagia, in broiler chickens. Br. Poult. Sci. 2005, 46, 144-148.
• 4. Baert K., Duchateau L., De Boever S., Cherlet M., De Backer P.: Antipyretic effect of oral sodium salicylate after an intravenous E. coli LPS injection in broiler chickens. Br. Poult. Sci. 2005, 46, 137-143.
• 5. Brattsand R., Linden M.: Cytokine modulation by glucocorticoids: mechanisms and actions in cellular studies. Aliment. Pharmacol. Ther. 1996, 10, 81-90.
• 6. Bye A., Lewis Y., O’Grady J.: Effect of a single oral dose of aspirin on the platelet aggregation response to arachidonic acid. Br. J. Clin. Pharmacol. 1979, 7, 283-286.
• 7. Cooper K. E., Blahser S., Palkinson T. J., Merker G., Roth J., Zeisberger E.: Changes in body temperature and vasopressin content of brain neurons in pregnant and non pregnant guinea pigs during fever produced by Poly I:Poly C. Pflügers Arch. 1988, 412, 292-296.
• 8. Couto C. G.: Zespół rozsianego krzepnięcia wewnątrznaczyniowego u psów i kotów. Weterynaria po Dyplomie 2000, 1, 41-46.
• 9. Dinarello C. A., Bodel P. T., Atkins E.: The role of liver in the production of fever and in pyrogenic tolerance. Trans. Assoc. Am. Physicans 1968, 81, 334-344.
• 10. Dudek K.: Wpływ lipopolisacharydu na wystąpienie i przebieg gorączki, kształtowanie się tolerancji pirogenowej oraz wskaźniki immunologiczne i zapalne u gołębi. Praca dokt., Wydział Medycyny Weterynaryjnej AR, Lublin 2007.
• 11. Dudek K., Bednarek D.: Cellular immune response of pigeons in the conditions of endotoxin fever and pyrogenic tolerance. Pol. J. Vet. Sci. 2011, 14, 127-133.
• 12. Dudek K., Bednarek D., Siwicki A. K., Rokita E., Studziński T.: The effect of LPS injections on non-specific immune response in affected pigeons. Pol. J. Vet. Sci. 2013, 16, 723-729.
• 13. Flower R. J.: Lipocortin and the mechanism of action of the glucocorticoids. Br. J. Pharmacol. 1988, 94, 987-1015.
• 14. Fraifeld V., Blaicher-Kulick R., Degen A. A., Kaplanski J.: Is hypothalamic prostaglandin E2 involved in avian fever? Life Sci. 1995, 56, 1343-1346.
• 15. Gray D. A., Ironside C. S., Maloney S. K.: Modulation of plasma antidiuretic hormone levels does not change the magnitude of the LPS-induced febrile response in Pekin ducks. J. Comp. Physiol. B 2000, 170, 315-320.
• 16. Gray D. A., Maloney S. K., Kamerman P. R.: Lipopolysaccharide-induced fever in Pekin ducks is mediated by prostaglandins and nitric oxide and modulated by adrenocortical hormones. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 289, R1258-R1264.
• 17. Gregorut F. P., Baptista L. C., Paulim A. S., Guerreiro J. R., Secato E. R., Macari M.: Influence of age on the febrile response to E. coli and S. typhimurium endotoxins in growing pullets. Br. Poult. Sci. 1992, 33, 769-774.
• 18. Henderson B., Wilson M.: Cytokines induction by bacteria: beyond lipopolysaccharide. Cytokine 1996, 8, 269-282.
• 19. Johnson R. W., Curtis S. E., Dantzer R., Bahr J. M., Kelley K. W.: Sickness behavior in birds caused by peripheral or central injection of endotoxin. Physiol. Behav. 1993, 53, 343-348.
• 20. Johnson R. W., Curtis S. E., Dantzer R., Kelley K. W.: Central and peripheral prostaglandins are involved in sickness behavior in birds. Physiol. Behav. 1993, 53, 127-131.
• 21. Jones C. A., Edens F. W., Denbow D. M.: Influence of age on the temperature response of chickens to Escherichia coli and Salmonella typhimurium endotoxins. Poult. Sci. 1983, 62, 1553-1558.
• 22. Kaszowska M.: Budowa chemiczna i biosynteza lipopolisacharydu – ważnego składnika osłony komórkowej bakterii Gram-ujemnych. Post. Hig. Med. Dośw. 2004, 58, 333-342.
• 23. Kluger M. J., Kozak W., Leon L. R., Soszynski D., Conn C. A.: Cytokines and fever. Neuroimmunomodulation 1995, 2, 216-223.
• 24. Koutsos E. A., Klasing K. C.: The acute phase response in Japanese quail (Coturnix coturnix japonica). Comp. Biochem. Physiol. C Toxicol. Pharmacol. 2001, 128, 255-263.
• 25. Krzymowski T., Przała J. (red.): Fizjologia zwierząt. Państwowe Wydawnictwo Rolnicze i Leśne, Warszawa 2005.
• 26. Leshchinsky T. V., Klasing K. C.: Divergence of the inflammatory response in two types of chickens. Dev. Comp. Immunol. 2001, 25, 629-638.
• 27. Macari M., Furlan R. L., Gregorut F. P., Secato E. R., Guerreiro J. R.: Effects of endotoxin, interleukin-1 beta and prostaglandin injections on fever response in broilers. Br. Poult. Sci. 1993, 34, 1035-1042.
• 28. Maloney S. K., Gray D. A.: Characteristics of the febrile response in Pekin ducks. J. Comp. Physiol. B 1998, 168, 177-182.
• 29. Marais M., Maloney S. K., Gray D. A.: The development of endotoxin tolerance, and the role of hypothalamo-pituitary-adrenal function and glucocorticoids in Pekin ducks. J. Exp. Biol. 2011, 214, 3378-3385.
• 30. Matsuura M., Kiso M., Hasegawa A., Nakano M.: Multistep regulation mechanisms for tolerance induction to lipopolysaccharide lethality in the tumor-necrosis-factor-alpha-mediated pathway. Eur. J. Biochem. 1994, 221, 335-341.
• 31. Mazur-Gonkowska B., Koncicki A., Krasnodębska-Depta A.: Assessment of acute phase response in turkeys experimentally infected with Escherichia coli or haemorrhagic enteritis virus. Bull. Vet. Inst. Pulawy 2004, 48, 19-23.
• 32. Nistico G., Marley E.: Central effects of prostaglandins E2, A1 and F2alpha in adult fowls. Neuropharmacology 1976, 15, 737-741.
• 33. Nomoto S.: Diurnal variations in fever induced by intravenous LPS injection in pigeons. Pflügers Arch. – Eur. J. Physiol. 1996, 431, 987-989.
• 34. Nomoto S.: LPS fever in pigeons. Ann. N. Y. Acad. Sci. 1997, 813, 508-511.
• 35. Nomoto S.: Role of prostaglandin E2 and indomethacin in the febrile response of pigeons. Jpn. J. Physiol. 2003, 53, 253-258.
• 36. Parosińska A., Pierzchała K.: Koncepcje oporności na aspirynę. Neurol. Neurochirur. Pol. 2006, 40, 313-319.
• 37. Pittman Q. J., Veale W. L., Cockeram A. W., Cooper K. E.: Changes in body temperature produced by prostaglandins and pyrogens in the chicken. Am. J. Physiol. 1976, 230, 1284-1287.
• 38. Roth J., McClellan J. L., Kluger M. J., Zeisberger E.: Attenuation of fever and release of cytokines after repeated injections of lipopolysaccharide in guinea-pigs. J. Physiol. 1994, 477, 177-185.
• 39. Soszyński D.: Mechanizmy wzbudzania tolerancji na powtarzane iniekcje pirogenów egzogennych. Post. Hig. Med. Dośw. 2000, 54, 537-551.
• 40. Soszyński D., Kozak W., Szewczenko M.: Course of fever response to repeated administration of sublethal doses of lipopolysaccharides, polyinosinic:polycytidylic acid and muramyl dipeptide to rabbits. Experientia 1991, 47, 43-47.
• 41. Traczyk W. Z., Trzebski A. (red.): Fizjologia człowieka z elementami fizjologii stosowanej i klinicznej. Wydawnictwo Lekarskie PZWL, Warszawa 2001.
• 42. Zeisberger E., Roth J.: Tolerance to pyrogens. Ann. N. Y. Acad. Sci. 1998, 856, 116-131.