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2017 | 20 | 3 |

Tytuł artykułu

A trial of doramectin injection and ivermectin spot-on for treatment of rabbits artificially infested with the ear mite “Psoroptes cuniculi”

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The ear mite “Psoroptes cuniculi” is the main cause of ear mange, a highly contagious parasitic skin disease in rabbits all over the world. In the current work, a preliminary therapeutic trial to study the effect of the broad use acaricides doramectin and ivermectin on P. cuniculi was performed on artificially infested rabbits. Twenty five adult New Zealand white rabbits were used in this study. The rabbits were assigned randomly into five groups/ 5 rabbits in each group. Each rabbit was experimentally infested with 100 mites/ ear. The first group was designated the positive control group and was not treated. The second and third groups were treated with doramectin 200 and 400 μg/kg bw, respectively. Groups 4 and 5 were treated by dressing with ivermectin in one dose and 2 doses with a 1 week interval. After the therapy, all rabbits were examined microscopically on the 7th, 14th, and 28th day post treatment and the number of live mites (larvae, nymphs, and adults) on each rabbit was counted at the end of the experiment (28th day). The results showed that the rabbits treated subcutaneously with doramectin at a single dose of 200 μg /kg bw showed a very low effect, although there was significant improvement when the dose was doubled to 400 μg /kg bw, with the number of mites counted decreasing significantly. Rabbits treated topically with ivermectin spot-on, a single dose or 2 doses, showed great improvement of the lesion: the number of mites was reduced to zero. In conclusion, this work showed that ivermectin spot-on applied locally on infested ears proves to be more effective against P. cuniculi than doramectin injected subcutaneously. Further trials on ear mange therapeutics in rabbits are to be encouraged.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

20

Numer

3

Opis fizyczny

p.521-525,fig.,ref.

Twórcy

  • Department of Parasitology, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt
  • Department of Parasitology, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt
  • Department of Poultry Diseases, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt
autor
  • Department of Pathology and Parasitology, Faculty of Veterinary Medicine, Damanhour University, 22111 Damanhour, Egypt
autor
  • Department of Parasitology, Faculty of Veterinary Medicine, Kafrelsheikh University, 33516 Kafrelsheikh, Egypt

Bibliografia

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  • Bates PG (1999) Inter and intra-specific variation within the genus Psoroptes (Acari: Psoroptidae). Vet Parasitol 83: 201-217.
  • Beck W (2000) Ear mange in domestic rabbit caused by Psoroptes cuniculi (Acari: Psoroptidae) –Biology of Psoroptes cuniculi, pathogenesis, clinical features, diagnosis and treatment. Kleintierprax 45: 301-308.
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  • Calleros CH, Montor JM, Montiel JA, Hoffman KL, Rodrtguez AN, Perez FI (2013) Hormonal and behavioral changes induced by acute and chronic experimental infestation with Psoroptes cuniculi in the domestic rabbit Oryctolagus cuniculus. Paras Vectors 6: 361.
  • Chabala JC, Mrozik H, Tolman RL, Eskola P, Lusi A, Peterson LH (1980) Ivermectin, a new broad-spectrum antiparasitic agent. J Med Chem 23: 1134-1136.
  • El-AbasyMA, Desouky AY, Abdien HM(2008) Comparative field efficacy of systemic, oral and topical application of ivermectin against Psoroptes cuniculi, the ear mange mite in naturally infected rabbits. Kafrelsheikh Vet Med J 6: 460-470.
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  • Hughes JE (2004) Diagnosis and treatment of selected rabbit dermatologic disorders. Exot DVM 5: 18-20.
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  • Lekimme M, Mignon B, Tombeux S, Focant C,Marechal F, Losson B (2006) In vitro entomopathogenic activity of Beauveria bassiana against Psoroptes spp. (Acari: Psoroptidae). Vet Parasitol 139: 196-202.
  • McTier TL, Hair A, Walstrom DJ, Thompson L (2003) Efficacy and safety of topical administration of selamectin for treatment of ear mite infestation in rabbits. J Am Vet Med Assoc 223: 322-324.
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  • Siegfried E, Ochs H, Deplazes P (2004) Clinical development and serological antibody responses in sheep and rabbits experimentally infested with Psoroptes ovis and Psoroptes cuniculi. Vet Parasitol 124: 109-124.
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Typ dokumentu

Bibliografia

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