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2008 | 68 | 4 |
Tytuł artykułu

Effect of FK506 administration after obturator nerve injury: a functional and ultrastructural study

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
The frequency of obturator nerve damage due to pelvic diseases, fractures or gynecologic procedures is uncertain. In the present study, we investigated the effect of FK506, a potent macrolide antibiotic and immunosuppresant, on obturator nerve recovery at morphological and functional levels. Forty female Wistar rats were randomly divided into four groups (control, sham, FK506-treated, vehicle-treated). In half of animals (FK506-treated and vehicle-treated) an obturator nerve crush (30 seconds clamp) was created. In FK506-treated group FK506 administration (1 mg/kg/day, subcutaneously) was performed on each postoperative day. All the rats were functionally evaluated by pinch and adduction tests preoperatively and postoperatively at one, two, three and four weeks after nerve injury. On the 28th postoperative day obturator nerve samples were collected and analyzed qualitatively by light and electron microscopy. FK506 treatment resulted in dramatic improvement in nerve function and in the ultrastructure of nerve fibers suggesting its therapeutic potential in traumatic obturator nerve injury.
Słowa kluczowe
EN
Wydawca
-
Rocznik
Tom
68
Numer
4
Opis fizyczny
p.477-483,fig.,ref.
Twórcy
  • Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, Turkey
  • Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, Turkey
autor
  • Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, Turkey
autor
  • Department of Histology and Embryology, Akdeniz University Faculty of Medicine, Antalya, Turkey
  • Electron Microscopy Unit (TEMGA), Akdeniz University Faculty of Medicine, Antalya, Turkey
autor
  • Electron Microscopy Unit (TEMGA), Akdeniz University Faculty of Medicine, Antalya, Turkey
autor
  • Department of Anatomy, Akdeniz University Faculty of Medicine, Antalya, Turkey
Bibliografia
Uwagi
PL
Rekord w opracowaniu
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-4adbb842-7d7c-497f-bdd4-c4014357394e
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