In vivo inhibitory effect of Aloe vera gel on the ability of mouse parental splenic lymphocytes to induce cutaneous angiogenesis in recipient F1 mice

• Autorzy: Skopinski P. , Lewicki S. , Balan B. J. , Kocik J. , Zdanowski R. , Skopinska-Rozewska E. , Siwicki A. K.
• Języki publikacji: EN

Abstrakty

EN

Lymphocyte-induced angiogenesis test (LIA) is a model of local graft-versus-host (GVH) reaction, marker of the earliest events resulting from activation of donor lymphocytes after contact with host semi-allogeneic histocompatibility antigens. The effect of in vivo oral administration of Aloe vera gel for 21 days to maternal strain (Balb/c) donor mice on the ability of their splenic lymphocytes to induce cutaneous angiogenesis (LIA test) in F1 Balb/c x C3H recipients, was studied. Results: Neovascular reaction evaluated 72 hours after cells grafting was significantly lower in F1 mice grafted with lymphocytes collected from Aloe- fed donors, than in recipients of lymphocytes collected from respective controls. Conclusions: This observation opens the promise of safe and ethically acceptable possibility of use of Aloe vera gel in human donors in prevention of GVHD in recipients of bone marrow grafts.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2014
• Tom: 17
• Numer: 1
• Opis fizyczny: p.131-136,fig.,ref.

Twórcy

autor

Skopinski P.

• Department of Histology and Embryology, Center for Biostructure Research, Warsaw Medical University, Chałubinskiego 5, 02-004 Warsaw, Poland

autor

Lewicki S.

• Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Kozielska 4.01-163, Warsaw, Poland

autor

Balan B. J.

• Department of Immunology, Biochemistry and Nutrition, Warsaw Medical University, Pawinskiego 3a, 01-002 Warsaw, Poland

autor

Kocik J.

• Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Kozielska 4.01-163, Warsaw, Poland

autor

Zdanowski R.

• Department of Regenerative Medicine, Military Institute of Hygiene and Epidemiology, Kozielska 4.01-163, Warsaw, Poland

autor

Skopinska-Rozewska E.

• Pathology Department, Center for Biostructure Research, Warsaw Medical University, Chałubinskiego 5, 02-004, Warsaw, Poland

autor

Siwicki A. K.

• Department of Microbiology and Clinical Immunology, University of Warmia and Mazury, Oczapowskiego 13, 10-957 Olsztyn, Poland

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Identyfikatory

DOI

10.2478/pjvs-2014-0017