Preliminary study on the impact of methanolic extract of Elephantopus scaber Linn. on hair growth promoting effect in rats

• Autorzy: Sahoo H.B. , Sagar R. , Bhattamisra S. K. , Bhaiji A.

Warianty tytułu

PL

Wstępne badanie wpływu wyciągu metanolowego z Elephantopus scaber Linn. na proces wspomagania wzrostu owłosienia u szczurów

• Języki publikacji: EN

Abstrakty

EN

Methanolic extract of Elephantopus scaber leaves was investigated for its role in hair growth in experimental rats. The 2% and 5% solution of prepared formulation using methanolic extract was studied for hair growth on wistar rats for 30 days. Minoxidil (2% solution) was taken as a reference standard. The prepared hair oil formulation of methanolic extract significantly (p<0.01) potentiated the hair growth initiation and completion time with dosedependent improvement in skin biopsy, hair length and hair weight. In vitro hair follicles development study showed the significant (p<0.05) improvement in the initiation of new hair follicles. Above mentioned results indicated that the methanolic extract of E. scaber rendered significant hair growth promotive effect.

PL

Badano wpływ wyciągu metanolowego z liści Elephantopus scaber na wzrost włosów u szczurów laboratoryjnych. Przez 30 dni badano wzrost włosów u szczurów Wistar po podaniu 2% i 5% preparatu sporządzonego z użyciem ekstraktu metanolowego. Substancją kontrolną był minoksidil (roztwór 2 %). Preparat z ekstraktu metanolowego przygotowany na bazie oleju istotnie (p<0,01) zwiększał inicjację wzrostu włosów i przyspieszał jego zakończenie. Podczas biopsji odnotowano też zależną od dawki poprawę stanu skóry, długości włosów i zwiększenie masy włosów. Podczas badaniu in vitro wykazano istotną (p<0,05) poprawę tworzenia się nowych mieszków włosowych. Powyższe wyniki wskazują, że wyciąg metanolowy z E. scaber może istotnie zwiększać porost włosów.

Słowa kluczowe

EN

methanolic extract; Elephantopus scaber; hair growth; promoting effect; rat; hair loss; baldness zob.alopecia; alopecia

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2013
• Tom: 59
• Numer: 2
• Opis fizyczny: p.35-45,ref.

Twórcy

autor

Sahoo H.B.

• Department of Pharmacology and Toxicology, Vedica College of Pharmacy, Bhopal 462021, Madhya Pradesh, India

autor

Sagar R.

• Department of Pharmacognosy and Phytochemistry, Dr.H.S.Gour Central University, Sagar, 470003 Madhya Pradesh, India

autor

Bhattamisra S. K.

• Department of Pharmacology, Roland Institute of Pharmaceutical Sciences, Berhampur 760010, Orissa, India

autor

Bhaiji A.

• Department of Pharmacology and Toxicology, Vedica College of Pharmacy, Bhopal 462021, Madhya Pradesh, India

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