Position and size of massa intermedia in Serbian brains

• Autorzy: Pavlovic M.N. , Jovanovic I.D. , Ugrenovic S.Z. , Kostic A.V. , Kundalic B.K. , Stojanovic V.R. , Vlajkovic S. , Trandafilovic M.M. , Cukuranovic-Kokoris J.R. , Antic M.M.
• Języki publikacji: EN

Abstrakty

EN

Background: Massa intermedia, a midline bar-shaped structure, connects two thalami across the third ventricle in 70–80% of healthy humans. It has become clinically important since its absence was comprehended as a midline malformation of the brain and brought in connection with schizophrenia indicating that some symptoms could be a consequence of disturbed neuron chains underlying the mechanisms of attention and processing of information. The aim of the investigation was to find out the incidence, position, and size of massa intermedia in the brains of the Serbian population. Materials and methods: Our investigation was performed on 41 brains of adult Serbian cadavers using a macro dissection method. Results: Massa intermedia was present in 80.49% of cases, in 1 case it was double. In most of the cases it was located in the superior quadrants of the lateral wall of the third ventricle, the larger part being in the anterosuperior one. Some other combinations were also present. The horizontal diameter of the cross-section was larger than vertical and was not in correlation with the length of the third ventricle. The average cross-sectional area was 29.58 mm², significantly larger in females. Conclusions: Massa intermedia is present in most of the investigated brains, usually connecting the anterior-superior quadrants of the lateral walls of the third ventricle. Different in shape and size its cross-section is a horizontal ellipse, significantly larger in females. The cross-sectional area and the size of the third ventricle are not in correlation. (Folia Morphol. 2020; 79, 1: 21–27)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2020
• Tom: 79
• Numer: 1
• Opis fizyczny: p.21-27,fig.,ref.

Twórcy

autor

Pavlovic M.N.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Jovanovic I.D.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Ugrenovic S.Z.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Kostic A.V.

• 2Neurosurgery Clinic, Clinical Centre Nis, Nis, Serbia and Montenegro

autor

Kundalic B.K.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Stojanovic V.R.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Vlajkovic S.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Trandafilovic M.M.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Cukuranovic-Kokoris J.R.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

autor

Antic M.M.

• Medical Faculty, University of Nis, Nis, Serbia and Montenegro

Bibliografia

• 1. Agarwal N, Rambaldelli G, Perlini C, et al. Microstructural thalamic changes in schizophrenia: a combined anatomic and diffusion weighted magnetic resonance imaging study. J Psychiatry Neurosci. 2008; 33(5): 440–448, indexed in Pubmed: 18787663.
• 2. Allen LS, Gorski RA. Sexual dimorphism of the anterior commissure and massa intermedia of the human brain. J Comp Neurol. 1991; 312(1): 97–104, doi: 10.1002/cne.903120108, indexed in Pubmed: 1744245.
• 3. Baydin S, Gungor A, Baran O, et al. The double massa intermedia. Surg Neurol Int. 2016; 7: 30, doi: 10.4103/2152-7806.179383, indexed in Pubmed: 27127695.
• 4. Carpenter MB. Thalamus in: core text of neuroanatomy. 4th ed. Williams&Wilkins, Baltimore 1996: 49–50.
• 5. Cataltepe O. Endoscopic third ventriculostomy: indications, surgical technique, and potential problems. Turk Neurosurg. 2002; 12: 65–73.
• 6. Ceyhan M, Adapınar B, Aksaray G, et al. Absence and size of massa intermedia in patients with schizophrenia and bipolar disorder. Acta Neuropsychiatr. 2008; 20(4): 193–198, doi: 10.1111/j.1601-5215.2008.00296.x, indexed in Pubmed: 25385654.
• 7. Collins P. Embriology and development. In: Williams PL (ed.) Gray’s anatomy. 38th ed. Churchill Livingstone, London 1995: 91–328.
• 8. Di Rocco C. Massa intermedia: mental development. Childs Nerv Syst. 2005; 21(12): 1013–1017, doi: 10.1007/s00381-005-1265-7, indexed in Pubmed: 16249940.
• 9. de Souza Crippa JA, Zuardi AW, Busatto GF, et al. Cavum septum pellucidum and adhesio interthalamica in schizophrenia: an MRI study. Eur Psychiatry. 2006; 21(5): 291–299, doi: 10.1016/j.eurpsy.2005.09.010, indexed in Pubmed: 16406503.
• 10. Erbağci H, Yildirim H, Herken H, et al. A magnetic resonance imaging study of the adhesio interthalamica in schizophrenia. Schizophr Res. 2002; 55(1-2): 89–92, doi: 10.1016/s0920-9964(01)00199-2, indexed in Pubmed: 11955967.
• 11. Haghir H, Mokhber N, Azarpazhooh MR, et al. A magnetic resonance imaging study of adhesio interthalamica in clinical subtypes of schizophrenia. Indian J Psychiatry. 2013; 55(2): 135–139, doi: 10.4103/0019-5545.111450, indexed in Pubmed: 23825846.
• 12. Hirayasu Y, Wada JA. N-methyl-D-aspartate injection into the massa intermedia facilitates development of limbic kindling in rats. Epilepsia. 1992; 33(6): 965–970, doi: 10.1111/j.1528-1157.1992.tb01745.x, indexed in Pubmed: 1464279.
• 13. Ligier Y, Ratib O, Logean M, et al. Osiris: a medical image-manipulation system. MD Comput. 1994; 11(4): 212–218, indexed in Pubmed: 8072405.
• 14. Malobabić S, Puskas L, Blagotić M. Size and position of the human adhaesio interthalamica. Gegenbaurs Morphol Jahrb. 1987; 133(1): 175–180, indexed in Pubmed: 3569816.
• 15. Meisenzahl EM, Frodl T, Zetzsche T, et al. Adhesio interthalamica in male patients with schizophrenia. Am J Psychiatry. 2000; 157(5): 823–825, doi: 10.1176/appi.ajp.157.5.823, indexed in Pubmed: 10784480.
• 16. Mori H, Oi S, Nonaka Y, et al. Ventricular anatomy of hydrocephalus associated with myeloschisis and endoscopic third ventriculostomy. Childs Nerv Syst. 2008; 24(6): 717–722, doi: 10.1007/s00381-007-0547-7, indexed in Pubmed: 18188572.
• 17. Nayak SB, Soumya KV. Unusually large interthalamic adhesion and its clinical importance. Int J Anat Var. 2010; 3: 174–175.
• 18. Nopoulos P, Swayze V, Flaum M, et al. Cavum septi pellucidi in normals and patients with schizophrenia as detected by magnetic resonance imaging. Biol Psychiatry. 1997; 41(11): 1102–1108, doi: 10.1016/S0006-3223(96)00209-0, indexed in Pubmed: 9146821.
• 19. Nopoulos PC, Rideout D, Crespo-Facorro B, et al. Sex differences in the absence of massa intermedia in patients with schizophrenia versus healthy controls. Schizophr Res. 2001; 48(2-3): 177–185, doi: 10.1016/s0920-9964(00)00067-0, indexed in Pubmed: 11295371.
• 20. Park K, Lee H, Chung I, et al. A morphologic study of interthalamic adhesions in Korean brains. Clini Anat. 1993; 6(1): 33–36, doi: 10.1002/ca.980060106.
• 21. Puskas L, Malobabić S, Puskas N, et al. Specific circular organization of the neurons of human interthalamic adhesion and of periventricular thalamic region. Int J Neurosci. 2005; 115(5): 669–679, doi: 10.1080/00207450590524340, indexed in Pubmed: 15823931.
• 22. Rosales RK, Lemay MJ, Yakovley PI. The development and involution of massa intermedia with regard to age and sex. J Neuropathol Exp Neurol. 1968; 27(1): 166, indexed in Pubmed: 5301516.
• 23. Sen F, Ulabay H, Ozeksi P, et al. Morphometric measurements of the thalamus and interhemispheric adhesion by MR imaging. Neuroanat. 2005; 4: 10–12.
• 24. Shimizu M, Fujiwara H, Hirao K, et al. Structural abnormalities of the adhesio interthalamica and mediodorsal nuclei of the thalamus in schizophrenia. Schizophr Res. 2008; 101(1-3): 331–338, doi: 10.1016/j.schres.2007.12.486, indexed in Pubmed: 18242957.
• 25. Snyder PJ, Bogerts B, Wu H, et al. Absence of the adhesio interthalamica as a marker of early developmental neuropathology in schizophrenia: an MRI and postmortem histologic study. J Neuroimaging. 1998; 8(3): 159–163, doi: 10.1111/jon199883159, indexed in Pubmed: 9664852.
• 26. Susser E, Brown AS, Klonowski E, et al. Schizophrenia and impaired homocysteine metabolism: a possible association. Biol Psychiatry. 1998; 44(2): 141–143, doi: 10.1016/s0006-3223(97)00427-7, indexed in Pubmed: 9646897.
• 27. Takahashi T, Suzuki M, Zhou SY, et al. Prevalence and length of the adhesio interthalamica in schizophrenia spectrum disorders. Psychiatry Res. 2008; 164(1): 90–94, doi: 10.1016/j.pscychresns.2008.03.001, indexed in Pubmed: 18790617.
• 28. Takahashi T, Suzuki M, Nakamura K, et al. Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia. Psychiatry Res. 2008; 162(2): 101–111, doi: 10.1016/j.pscychresns.2007.04.005, indexed in Pubmed: 18226506.
• 29. Trzesniak C, Kempton MJ, Busatto GF, et al. Adhesio interthalamica alterations in schizophrenia spectrum disorders: a systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2011; 35(4): 877–886, doi: 10.1016/j.pnpbp.2010.12.024, indexed in Pubmed: 21300129.
• 30. Trzesniak C, Linares IM, Coimbra ÉR, et al. Adhesio interthalamica and cavum septum pellucidum in mesial temporal lobe epilepsy. Brain Imaging Behav. 2016; 10(3): 849–856, doi: 10.1007/s11682-015-9461-x, indexed in Pubmed: 26497889.
• 31. Tubbs RS, Smyth MD, Oakes WJ, et al. Duplication of the massa intermedia in a child. Pediatr Neurosurg. 2004; 40(1): 42–43, doi: 10.1159/000076578, indexed in Pubmed: 15007230.
• 32. Wright P, Takei N, Rifkin L, et al. Maternal influenza, obstetric complications, and schizophrenia. Am J Psychiatry. 1995; 152(12): 1714–1720, doi: 10.1176/ajp.152.12.1714, indexed in Pubmed: 8526235.

Identyfikatory

DOI

10.5603/FM.a2019.0046