Tymczasowe dane o działaniu antyenzymu Ascaris na krzepnięcie krwi

• Autorzy: Kadlubowski R.

Warianty tytułu

EN

Preliminary observations on the effect bof Ascaris anti-enzyme on blood coagulation

RU

Predvaritel'nye dannye o dejjstvii antifermenta Ascaris na svertyvanie krovi

• Języki publikacji: PL

Abstrakty

EN

An enzyme with anti-peptic and anti-tryptic action was obtained from the body cavity fluid of Ascaris lumbricoides suis by means of frastionated alcohol precipitation in acid medium, at reduced temperature (Z. Wojciechowska). The anti-enzyme solution in 0.85% NaCl was added to oxalated human venous blood or guinea pig blood taken from the heart. After 5-minute stay at room temperature it was transferred to water bath at 37° and the blood coagulation time was determined after recalcination. The coagulation time was calculated in ralation to that of control samples taken as 100. The active concentration of the anti-enzyme was computed by means of straight regression equation. It was found that the Ascaris anti-enzyme brings about an increase in the coagulation time of man at the concentrations higher than 48.1 mg%; the concentration of 109.8 ± 24.6 mg% protracts the coagulation time by 50%. Similar action of the anti-enzyme on the guinea pig blood was observed at the concentrations higher than 27,9%.; the concentration, leading to 50% increase in the coagulation time, amounts to 135.2 ± 11.1 mg%. It is believed that the inhibition of blood coagulation, induced by Ascaris fluid, might be of biological importance, for instance during the migration of the parasite in the host organism.

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 1964
• Tom: 10
• Numer: 4-5
• Opis fizyczny: s.289-290

Twórcy

autor

Kadlubowski R.

• Katedra Biologii i Parazytologii Lekarskiej, Akademia Medyczna w Łodzi, Łódź