Dissecting activity of individual cell populations with kernel current source density method and independent components analysis

• Autorzy: Wojcik D.K. , Potworowski J. , Glabska H. , Leski S.
• Języki publikacji: EN

Abstrakty

EN

Local field potentials (LFP), the low-frequency part of extracellular electric potential, reflect dendritic processing of synaptic inputs to neuronal populations. Today one can easily record simultaneous potentials from multiple contacts. Due to the nature of electric field each electrode may record activity of sources millimeters away which leads to significant correlations between signals and complicates their analysis. Whenever possible it is convenient to estimate the current source density (CSD), the volume density of net transmembrane currents, which generate the LFP. CSD directly reflects the local neural activity and CSD analysis is often used to analyze LFP. We present here a general, nonparametric method for CSD estimation based on kernel techniques, which can take into account known anatomy or physiology of the studied structure. Using data from a simulated large scale model of thalamo-cortical column we also show how CSD analysis combined with independent component analysis (ICA) can reveal information on activity of individual cell populations. Research supported by grants 5428/B/P01/2010/39, POIG.02.03.00- 00-003/09, POIG.02.03.00-00-018/08.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2012
• Tom: 72
• Numer: 2
• Opis fizyczny: p.201

Twórcy

autor

Wojcik D.K.

• Department of Neurophysiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

autor

Potworowski J.

• Department of Neurophysiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

autor

Glabska H.

• Department of Neurophysiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

autor

Leski S.

• Department of Neurophysiology, Nencki Institute of Experimental Biology PAS, Warsaw, Poland

Uwagi

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