Prevalence of EBV genotypes in Polish, Taiwanese and Arabic healthy students and association between genotypes and 30-bp deletion in the LMP-1 gene phylogenetic analysis

• Autorzy: Polz D. , Podsiadlo L. , Stec A. , Polz-Dacewicz M.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to compare the prevalence of EBV genotype and del-LMP-1 in saliva from Polish, Taiwanese and Arabic healthy students. The study group consisted of 56 healthy students; 24 of them Polish, 25 Taiwanese, and 7 Arabic. Typing was carried out using PCR with EBNA-2 primers. A detection of LMP-1 variants was also performed using PCR. EBV DNA was detected in 22 investigated samples (39.3%). Type 1 of the virus was dominant in both Polish and Taiwanese group. Among 62.5% Tai wanese with EBV 1 and 55.6% Polish detected EBV with 30-bp deletion in LMP-1 gene.

Słowa kluczowe

EN

prevalence; Epstein-Barr virus; genotype; Poland; Taiwan; Arab; healthy man; student; LMP1 gene; phylogenetic analysis

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2014
• Tom: 63
• Numer: 1
• Opis fizyczny: p.105-109,fig.,ref.

Twórcy

autor

Polz D.

• Department of Virology, Medical University, Lublin, Poland

autor

Podsiadlo L.

• Department of Virology, Medical University, Lublin, Poland

autor

Stec A.

• Department of Virology, Medical University, Lublin, Poland

autor

Polz-Dacewicz M.

• Department of Virology, Medical University, Lublin, Poland

Bibliografia

• Alipov G., T. Nakayama, M. Nakashima, C.Y. Wen, D. Niino, H. Kondo, Y. Pruglo and I. Sekine. 2005. Epstein-Barr virus-associated gastric carcinoma in Kazakhstan. World J. Gastroenterol. 11: 27–30.
• Bei J.X., Y. Li, W.H. Jia, B.J. Feng, G. Zhou, L.Z. Chen, O.S. Feng, HQ Low, H. Zhang, F. He and others. 2010. A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci. Nat. Genet. 42: 599–603.
• Chen W.G., Y.Y. Chen, M.M. Bacchi, C.E. Bacchi CE., M. Alvarenga and L.M. Weiss. 1996. Genotyping of Epstein-Barr virus in Brazilian Burkitt’s lymphoma and reactive lymphoid tissue. Type A with a high prevalence of deletions within the latent membrane protein gene. Am. J. Pathol. 148: 17–23.
• Chen M.R. 2011. Epstein-Barr virus, the immune system, and associated diseases. Front Microbiol. 2: 5.
• Correa R.M., M.D. Fellner, L.V. Alonio, K. Durand, A.R. Teyssié, and M.A. Picconi. 2004. Epstein-Barr virus (EBV) in healthy carriers: Distribution of genotypes and 30 bp deletion in latent membrane protein-1 (LMP-1) oncogene. J. Med. Virol. 73: 583–588.
• Correa R.M., M.D. Fellner, K. Durand, L. Redini, V. Alonio, C. Yampolsky, A. Colobraro, G. Sevlever, A. Teyssié and others. 2007. Epstein Barr virus genotypes and LMP-1 variants in HIV-infected patients. J. Med. Virol. 79: 401–407.
• Dirnhofer S., Angeles-Angeles A., Ortiz-Hidalgo C., Reyes E., Gredler E., J. Krugmann, F. Fend and L. Quintanilla-Martinez. 1999. High prevalence of a 30-base pair deletion in the Epstein-Barr virus (EBV) latent membrane protein 1 gene and of strain type B EBV in Mexican classical Hodgkin’s disease and reactive lymphoid tissue. Hum. Pathol. 30: 781–787.
• Dolcetti R., P. Zancai, V. De Re, A. Gloghini, B. Bigoni, B. Pivetta, S. De Vita, A. Carbone and M. Boiocchi. 1997. Epstein-Barr virus strains with latent membrane protein-1 deletions: prevalence in the Italian population and high association with human immunodeficiency virus-related Hodgkin’s disease. Blood. 89: 1723–1731.
• Farnaud S.J., O. Kosti, S.J. Getting and D. Renshaw. 2010. Saliva: Physiology and Diagnostic Potential in Health and Disease. Scientific World Journal 10: 434–456.
• Grinde B. and I. Olsen. 2010. The role of viruses in oral disease. J. Oral. Microbiol. 12: 2.
• Lin SY., N.M. Tsang, S.C. Kao, Y.L. Hsieh, Y.P. Chen, C.S. Ksai, T.T. Kuo, S.P. Hao, I.H. Chen and J.H. Hong. 2001. Presence of Epstein-Barr virus latent membrane protein 1 gene in the nasopharyngeal swabs from patients with nasopharyngeal carcinoma. Head Neck. 23: 194–200.
• Pan S.H., C.C. Tai, C.S. Lin, W.B. Hsu, S.F. Chou, C.C. Lai, J.Y. Chen, H.F. Tien, F.Y. Lee and W.B. Wang. 2009. Epstein-Barr virus nuclear antigen 2 disrupts mitotic checkpoint and causes chromosomal instability. Carcinogenesis 30: 366–375.
• Peh S.C., L.H. Kim, K.S. Mun, E.L. Tan, C.K. Sam and S. Poppema. 2003. Epstein-Barr virus (EBV) subtypes and variants in malignant tissue from Malaysian patients. J. Clin. Exp. Hematopathol. 43: 61–69.
• Perera RA., L.P. Samaranayake and C.S. Tsang. 2010. Shedding dynamics of Epstein-Barr virus: A type 1 carcinogen. Arch. Oral. Biol. 55: 639–647.
• Pow E.H., M.Y. Law, P.C. Tsang, R.A. Perera and D.L. Kwong. 2011 Salivary Epstein-Barr virus DNA level in patients with nasopharyngeal carcinoma following radiotherapy. Oral. Oncol. 9: 879–882.
• Proceedings of the IARC working group on the evaluation of carcinogenic risks to tumors. Epstein-Barr virus and Kaposi’s sarcoma Herpesvirus/Human herpesvirus 8. Lyon, France, 17–24 June 1997. IARC Monogr Eval Cacinog Risks Hum. 1997; 70: 1–492
• Shirtcliff E.A., D.A. Granger, E. Schwartz and M.J. Curran. 2001. Use of salivary biomarkers in biobehavioral research: cotton-based sample collection methods can interfere with salivary immunoassay results. Psychoneuroendocrinology 26: 165–73
• Slots J. 2005. Herpesviruses in periodontal diseases. Periodontol 2000. 38: 33–62.
• Slots J., I. Saygun, M. Sabeti and A. Kubar. 2006. Epstein-Barr virus in oral diseases. J. Periodontal. Res. 41: 235–244.
• Ruan H.L., H.D. Qin, Y.Y. Shugart, J.X. Bei, F.T. Luo, Y.X. Zeng and W.H. Jia. 2013. Developing genetic epidemiological models to predict risk for nasopharyngeal carcinoma in high-risk population of China. PLoS One. 82:e56128. doi: 10.1371/journal.pone.0056128
• Sandvej K., S.C. Peh, B.S. Andresen and G. Pallesen. 1994. Identification of potential host spots in the carboxy-terminal part of Epstein-Barr virus (EBV) BNLF-1 gene in both malignant and benign EBV-associated diseases; High frequency of a 39-bp deletion in Malaysian and Danish peripheral T-cell lymphomas. Blood. 84: 4053–4060
• Thompson M.P. and R. Kurzrock. 2004. Epstein-Barr virus and cancer. Clin. Cancer. Res. 10: 803–821
• Tiwawech D., P. Srivatanakul, A. Karalak and T. Ishida. 2008. Association between EBNA2 and LMP1 subtypes of Epstein-Barr virus and nasopharyngeal carcinoma in Thais. J. Clin. Virol. 42: 1–6.
• Tse KP., W.H. Su, K.P. Chang, N.M. Tsang, C.J. Yu, P. Tang, L.C. See, C. Hsueh, M.L. Yang, S.P. Hao and others. 2009. Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3. Am. J. Hum. Genet. 852: 194–203
• Wojciechowska U., J. Didkowska and W. Zatoński. 2012. Cancer in Poland in 2010, http://www.onkologia.org.pl/doc/Nowotw2010.pdf