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1988 | 39 | 5-6 |

Tytuł artykułu

Effect of exhaustive exercise on liver mitochondrial function in the rat

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Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Bielecki, J.W., Pawlicka, E. and Górski, J.: Effect of exhaustive exercise on liver mitochondrial function in the rat. Acta physiol, pol., 1968, 39(5-6): 421-406. The oxidative and phosphorylative function of rat liver mitochondria after exhaustive exercise was investigated. The stimulation of state 4 respiration (without ADP) with NADH and FADH₂ dependent substrates was demonstrated. The reduction in RCR ratio (the rate of oxidation in state 3/the rate of oxidation in state 4) and enhanced activity of oligomycin sensitive ATP-ase was also found. The results suggest an inhibition of liver mitochondrial phosphorylative activity in rats exercised till exhaustion.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

39

Numer

5-6

Opis fizyczny

p.421-426,ref.

Twórcy

  • Departments of Physiology and Biochemistry, School of Medicine, Bialystok, Poland
autor
  • Departments of Physiology and Biochemistry, School of Medicine, Bialystok, Poland
autor
  • Departments of Physiology and Biochemistry, School of Medicine, Bialystok, Poland

Bibliografia

  • 1. Ahlborg, G., Felig, P., Hagenfeldt, L., Hendler, R., Wahren, J. (1974) Substrate turnover during prolonged exercise in man. J. Clin. Invest. 53. 1080-1093.
  • 2. Ardies, M.C., Morris, G.S., Erickson, C.K., Farrar, R. P., (1987) Effects of exercise and ethanol on liver mitochondrial function. Lite Sci. 40. 1053-1061.
  • 3. Barakat, H.A., Kasperek, G.J., Dohm, G.L., Tapscott, E.B., Soider, R.D. (1982) Fatty acid oxidation by liver and muscle preparations of exhaustively exercised rats. Biochem J. 208. 419-424.
  • 4. Bobyleva-Guarriero, V., Jannone, A., Di Lisa, F., Capone, R., Siliprandi, N. (1985) Effect of aerate exercise and L-carnitine administration on rat liver, mitochondria. IRCS Med. Sci. 13. 866-869.
  • 5. Chance, B., Williams, G.R. (1955) Respiratory enzymes in oxidative phospohotylation. III. The stady state. J. Biol. Chem. 217. 409-427.
  • 6. Davies, K.J., Quintanilha, A.T., Brooks, G.A., Packer, I. (1982) Free radicals and tissue damage produced by exercise. Biochem. Biophys. Res. Commum 107. 1192-1205.
  • 7. Estabroek, R.W. (1967) Mitochondrial respiratory control and the polarographic measurement of ADP : 0 ratios. In Methods in Enzymology, Eds F. Estabrook, M.E., Pullman, pp. 41-47, Academic Press, New York.
  • 8. Galbo, H. .(1983) Hormonal and metabolic adaptation to exercise. Thiem - Stralton Inc., Stuttgart-New York.
  • 9. Glick, L.J. (1966) Effects of exercise on oxidative activities in rat liver mitochondria. Amer. J. Physiol. 210. 1215-1221.
  • 10. Harper, A.E. (1962) Methoden der enzymatischen Analyse. Edd. H V. Bergmayer, pp. 788-792, Verlag Chemie, Meiheim.
  • 11. Klug, G.A., Krause, J., Ustlund, A.K., Knoll, G., Brdiczka, D. (1934) Alterations in liver mitochondrial function as a result of fasting and exhaustive exercise. Biochem. Biophys. Acta. 764. 272-282.
  • 12. Matsuoka, L., Nakamura, T. (1979) Reversible effects of fatty acids on respiration, oxidative phosphorylation and heat production of rat liver mitochondria. J. Biochem 86. 675- 681.
  • 13. Rowell, L.B., Masoro, E.J., Spencer, M.j. (1965) Splanchnic metabolism in exercising man. J. Appl. Physiol. 20. 1032-1037.
  • 14. Stucki, J.W. (I960) The optimal efficiency and the economic degrees of coupling of oxidative phosphorylation. Europ. J. Biochem. 109. 269-283.
  • 15. Tate, CH.A., Wolkowicz, P.E., Me Millin-Wood, J. (1982) Exercise induced alterations of hepatic mitochondrial function. Biochem. J. 208. 695-701.
  • 16. Weinbach, E.C. (1961) Procedure for isolating stable mitochondria from rat liver and kidney. Anndi. Biochem. 2. 335-343.
  • 17. Winder, W.W. (1985) Regulation oi hepatic glucose production during exercise. Exercise and sport sciences reviews., Vol. 13. Ed. R.L. Terjung, Macmillan Publishing Company, New York.
  • 18. Williamson, J.R., Olson, M.S., Browning, E.Т., Scholz, R. (1969) Control oi the citricacid cycle in rat liver. The energy level and metabolic control in mitochondria. Ed. S. Papa, pp. 207-235, Adriatica Editrice, Bari.

Typ dokumentu

Bibliografia

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