Changes in NGF/c - Fos colocalization in specific limbic structures of juvenile and aged rats after open field stimulation

• Autorzy: Badowska-Szalewska E. , Klejbor I. , Cecot T. , Domaradzka-Pytel B. , Ludkiewicz B. , Morys J.
• Języki publikacji: EN

Abstrakty

EN

Changes in NGF release during stressful events have been associated with the activation of neurons expressing NGF receptors. This study examined the influence of acute stress-induced stimulation on NGF/c-Fos colocalization in the following limbic regions: the paraventricular (PV) nucleus of the hypothalamus, medial (MeA) nucleus of the amygdala, and CA3 hippocampus. Juvenile (P21) and aged rats (P360) were exposed to a 15-minute acute open field (OF) test. Double immunofluorescence staining, used to detect NGF-ir and c-Fos-ir cells, revealed a higher percentage of NGF/c-Fos-ir neurons in the P21 control group than in the P360 control group. Under OF acute stimulation, a statistically significant (p < 0.05) increase of NGF/c-Fos level in CA3 of juvenile animals and in PV and CA3 of the aged rats was observed. These observations indicate that the investigated structures in both age groups show a different response to acute OF stimulation. Acute OF affects the levels of NGF/c-Fos more significantly in aged rats. (Folia Morphol 2009; 68, 3: 129–134)

• Wydawca: -
• Czasopismo: Folia Morphologica
• Rocznik: 2009
• Tom: 68
• Numer: 3
• Opis fizyczny: p.129-134,fig.,ref.

Twórcy

autor

Badowska-Szalewska E.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Debinki 1, 80–211 Gdansk

autor

Klejbor I.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Debinki 1, 80–211 Gdansk

autor

Cecot T.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Debinki 1, 80–211 Gdansk

autor

Domaradzka-Pytel B.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Debinki 1, 80–211 Gdansk

autor

Ludkiewicz B.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Debinki 1, 80–211 Gdansk

autor

Morys J.

• Department of Anatomy and Neurobiology, Medical University of Gdansk, Debinki 1, 80–211 Gdansk

Bibliografia

• 1. Alleva E, Santucci D (2001) Psychosocial vs. “physical” stress situations in rodents and humans: role of neurotrophins. Physiol Behav, 73: 313–320.
• 2. Alleva E, Francia N (2009) Psychiatric vulnerability: suggestions from animal models and role of neurotrophins. Neurosci Biobehav Rev, 33: 525–536.
• 3. Aloe L, Alleva E, Fiore M (2002) Stress and nerve growth factor: findings in animal models and humans. Pharmacol Biochem Behav, 73: 159–166.
• 4. Badowska-Szalewska E, Klejbor I, Ludkiewicz B, Moryś J (2005) Analysis of calretinin immunoreactivity in the rat piriform cortex after open field stress during postnatal maturation. Folia Morphol, 64: 33–40.
• 5. Badowska-Szalewska E, Ludkiewicz B, Domaradzka-Pytel B, Dziewiątkowski J, Spodnik JH, Moryś J (2006) The immunoreactivity of c-Fos, NGF and its receptors TrkA after open-field exposure in the central and medial nuclei of the rat amygdala. Folia Morphol, 65: 145–151.
• 6. Bizon JL, Helm KA, Han J, Chun H, Pucilowska J, Lund PK, Gallagher M (2001) Hypothalamic-pituitary-adrenal axis function and corticosterone receptor expression in behaviourally characterized young and aged Long-Evans rats. Eur J Neurosci, 14: 1739–1751.
• 7. Blöchl A, Thoenen H (1996) Localization of cellular storage compartments and sites of constitutive and activity-dependent release of nerve growth factor (NGF) in primary cultures of hippocampal neurons. Mol Cell Neurosci, 7: 173–190.
• 8. Branchi I, Francia N, Alleva E (2004) Epigenetic control of neurobehavioural plasticity: the role of neurotrophins. Behav Pharmacol, 15: 353–362.
• 9. Brunson KL, Avishai-Eliner S, Hatalski CG, Baram TZ (2001) Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone. Mol Psychiatry, 6: 647–656.
• 10. Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ (2005) Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci, 25: 9328–9338.
• 11. Chang E, Young SI, Kay EP, Jong YK, Jong EL, Hyung KL (2008) The role of nerve growth factor in hyperosmolar stress induced apoptosis. J Cell Physiol, 216: 69–77.
• 12. Chen Y, Fenoglio KA, Dub, Grigoriadis DE, Baram TZ (2006) Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Mol Psychiatry, 11: 992–1002.
• 13. Chen Z, Yoshida S, Kato K, Momota Y, Suzuki J, Tanaka T, Ito J, Nishino H, Aimoto S, Kiyama H, Shiosaka S (1995) Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus. J Neurosci, 15: 5088–5097.
• 14. Cirulli F (2001) Role of environmental factors on brain development and nerve growth factor expression. Physiol Behav, 73: 321–330.
• 15. Dayas CV, Buller KM, Crane JW, Xu Y, Day TA (2001) Stressor categorization: acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups. Eur J Neurosci, 14: 1143–1152.
• 16. Duman RS, Monteggia LM (2006) A neurotrophic model for stress-related mood disorders. Biol Psychiatry, 59: 1116–1127.
• 17. Figueiredo HF, Bodie BL, Tauchi M, Dolgas CM, Herman JP (2003) Stress integration after acute and chronic predator stress: differential activation of central stress circuitry and sensitization of the hypothalamo-pituitary-adrenocortical axis. Endocrinology, 144: 5249–5258.
• 18. Gagliano H, Fuentes S, Nadal R, Armario A (2008) Previous exposure to immobilisation and repeated exposure to a novel environment demonstrate a marked dissociation between behavioral and pituitary-adrenal responses. Behav Brain Res, 187: 239–245.
• 19. Grace CE, Schaefer TL, Herring NR, Skelton MR, McCrea AE, Vorhees CV, Williams MT (2008) (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats. Synapse, 62: 110–121.
• 20. Hadjiconstantinou M, McGuire L, Duchemin A, Laskowski B, Kiecolt-Glaser J, Glaser R (2001) Changes in plasma nerve growth factor levels in older adults associated with chronic stress. J Neuroimmunol, 116: 102–106.
• 21. Hellweg R, Humpel C, Lowe A, Hortnagl H (1997) Moderate lesion of the rat cholinergic septohippocampal pathway increases hippocampal nerve growth factor synthesis: Evidence for long-term compensatory changes? Brain Res Mol Brain Res, 45: 177–181.
• 22. Hennigan A, O’Callaghan RM, Kelly AM (2007) Neurotrophins and their receptors: roles in plasticity, neurodegeneration and neuroprotection. Biochem Soc Trans, 35: 424–427.
• 23. Herman JP, Cullinan WE (1997) Neurocircuitry of stress: central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci, 20: 78–84.
• 24. Herman JP, Figueiredo H, Mueller NK, Ulrich-Lai Y, Ostrander MM, Choi DC, Cullinan WE (2003) Central mechanisms of stress integration: Hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol, 24: 151–180.
• 25. Huang Y, Cheng C, Hong C, Tsai S (2004) Expression of c-Fos-like immunoreactivity in the brain of mice with learned helplessness. Neurosci Lett, 363: 280–283.
• 26. Klejbor I, Ludkiewicz B, Domaradzka-Pytel B, Spodnik JH, Dziewiątkowski J, Moryś J (2006) Influence of the “open field” exposure on calbindin-D28k, calretinin, and parvalbumin containing cells in the rat midbrain. Developmental study. J Physiol Pharmacol, 57: 149–164.
• 27. Lang UE, Jockers-Scherubl MC, Hellweg R (2004) State of the art of the neurotrophin hypothesis in psychiatric disorders: Implications and limitations. J Neural Transm, 111: 387–411.
• 28. Leggio MG, Mandolesi L, Federico F, Spirito F, Ricci B, Gelfo F, Petrosini L (2005) Environmental enrichment promotes improved spatial abilities and enhanced dendritic growth in the rat. Behav Brain Res, 163: 78–90.
• 29. Lessmann V, Gottmann K, Malcangio M (2003) Neurotrophin secretion: current facts and future prospects. Prog Neurobiol, 69: 341–374.
• 30. Marais L, van Rensburg SJ, van Zyl JM, Stein DJ, Daniels WMU (2008) Maternal separation of rat pups increases the risk of developing depressive-like behavior after subsequent chronic stress by altering corticosterone and neurotrophin levels in the hippocampus. Neurosci Res, 61: 106–112.
• 31. Mercier S, Canini F, Buguet A, Cespuglio R, Martin S, Bourdon L (2003) Behavioural changes after an acute stress: stressor and test types influences. Behav Brain Res, 139: 167–175.
• 32. Meyza KZ, Boguszewski PM, Nikolaev E, Zagrodzka J (2007) The effect of age on the dynamics and the level of c-Fos activation in response to acute restraint in Lewis rats. Behav Brain Res, 180: 183–189.
• 33. Mocchetti I, De Bernardi MA, Szekely AM, Alho H, Brooker G, Costa E (1989) Regulation of nerve growth factor biosynthesis by beta-adrenergic receptor activation in astrocytoma cells: a potential role of c-Fos protein. Proc Natl Acad Sci USA, 86: 3891–3895.
• 34. Niewiadomska G, Baksalerska-Pazera M, Gasiorowska A, Mietelska A (2006) Nerve growth factor differentially affects spatial and recognition memory in aged rats. Neurochem Res, 31: 1481–1490.
• 35. Armario A (2004) Stress-induced activation of the immediate early gene Arc (activity-regulated cytoskeleton-associated protein) is restricted to telencephalic areas in the rat brain: relationship to c-fos mRNA. J Neurochem, 89: 1111–1118.
• 36. Onteniente B, Horellou P, Neveu I, Makeh I, Suzuki F, Bourdet C, Grimber G, Colin P, Brachet P, Mallet J, Briand P, Peschanski M (1994) Cell-type expression and regulation of a c-fos-NGF fusion gene in neurons and astrocytes of transgenic mice. Brain Res Mol Brain Res, 21: 225–234.
• 37. Pace TWW, Gaylord R, Topczewski F, Girotti M, Rubin B, Spencer RL (2005) Immediate-early gene induction in hippocampus and cortex as a result of novel experience is not directly related to the stressfulness of that experience. Eur J Neurosci, 22: 1679–1690.
• 38. Pfaff DW, Martin EM, Ribeiro AC (2007) Relations between mechanisms of CNS arousal and mechanisms of stress. Stress, 10: 316–325.
• 39. Pohl J, Olmstead MC, Wynne-Edwards KE, Harkness K, Menard JL (2007) Repeated exposure to stress across the childhood-adolescent period alters rats’ anxietyand depression-like behaviors in adulthood: the importance of stressor type and gender. Behav Neurosci, 121: 462–474.
• 40. Prut L, Belzung C (2003) The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: A review. Eur J Pharmacol, 463: 3–33.
• 41. Ghinelli E, Gu J, Hodges RR, Dartt DA (2007) Role of neurotrophins and neurotrophin receptors in rat conjunctival goblet cell secretion and proliferation. Investigative Invest Ophthalmol Vis Sci, 48: 1543–1551.
• 42. Sapolsky RM (1999) Glucocorticoids, stress, and their adverse neurological effects: relevance to aging. Exp Gerontol, 34: 721–732.
• 43. Sawchenko PE, Brown ER, Chan RKW, Ericsson A, Li H, Roland BL, Kovacs KJ (1996) The paraventricular nucleus of the hypothalamus and the functional neuroanatomy of visceromotor responses to stress. Prog Brain Res. 107: 201–222.
• 44. Schulte-Herbruggen O, Chourbaji S, Muller H, Danker-Hopfe H, Brandwein C, Gass P, Hellweg R (2006) Differential regulation of nerve growth factor and brain-derived neurotrophic factor in a mouse model of learned helplessness. Exp Neurol. 202: 404–409.
• 45. Semkova I, Krieglstein J (1999) Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors. Brain Res Rev, 30: 176–188.
• 46. Shumake J, Conejo-Jimenez N, Gonzalez-Pardo H, Gonzalez-Lima F (2004) Brain differences in newborn rats predisposed to helpless and depressive behavior. Brain Res, 1030: 267–276.
• 47. Tong L, Toliver-Kinsky T, Edwards M, Rassin DK, Werrbach-Perez K, Regino Perez-Polo J (2002) Attenuated transcriptional responses to oxidative stress in the aged rat brain. J Neurosci Res, 70: 318–326.
• 48. Trneckova L, Armario A, Hynie S, Sida P, Klenerova V (2006) Differences in the brain expression of c-fos mRNA after restraint stress in Lewis compared to Sprague-Dawley rats. Brain Res, 1077: 7–15.
• 49. Valvassori SS, Stertz L, Andreazza AC, Rosa MI, Kapczinski F, Streck EL, Quevedo J (2008) Lack of effect of antipsychotics on BNDF and NGF levels in hippocampus of Wistar rats. Metab Brain Dis, 23: 213–219.
• 50. Von Richthofen S, Lang UE, Hellweg R (2003) Effects of different kinds of acute stress on nerve growth factor content in rat brain. Brain Res, 987: 207–213.
• 51. Vyas A, Mitra R, Shankaranarayana Rao BS, Chattarji S (2002) Chronic stress induces contrasting patterns of dendritic remodeling in hippocampal and amygdaloid neurons. J Neurosci, 22: 6810–6818.
• 52. Yanagita S, Amemiya S, Suzuki S, Kita I (2007) Effects of spontaneous and forced running on activation of hypothalamic corticotropin-releasing hormone neurons in rats. Life Sci, 80: 356–363.