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2012 | 68 | 06 |

Tytuł artykułu

Rola tlenku azotu w regulacji czynności układu krążenia

Warianty tytułu

EN
Role of nitric oxide in the regulation of the cardiovascular function

Języki publikacji

PL

Abstrakty

EN
Nitric oxide (NO, earlier known as EDFR - Endothelium-Derived Relaxing Factor) is a multifunctional particle involved in physiological as well as pathological reactions. The specificity of these reactions depends on the NO concentration, location and interactions with other particles. Nitric oxide affects the dilatation of blood vessels and immunological reaction. It influences cardiovascular myocyte tonus (contraction) and counteracts vasoconstrictive factors such as endothelin-1 and angiotensin-II, thereby ensuring proper tissue perfusion depending on current requirements. NO protects vessel walls by preventing lipid peroxidation and decreasing the activity of reactive oxygen radicals. Nitric oxide shows anticoagulant properties by inhibiting the adhesion, activation and aggregation of trombocytes.

Wydawca

-

Rocznik

Tom

68

Numer

06

Opis fizyczny

s.349-352,bibliogr.

Twórcy

autor
  • Katedra Chorób Wewnętrznych z Kliniką Koni, Psów i Kotów, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy we Wrocławiu, pl.Grunwaldzki 47, 50-366 Wrocław
autor
autor
autor

Bibliografia

  • 1.Aji W., Ravalli S., Szabolcs M., Jiang X. C., Sciacca R. R., Michler R. E., Cannon P. J.: L-arginine prevents xanthoma development and inhibits atherosclerosis in LDL receptor knockout mice. Circulation. 1997, 95, 430-437.
  • 2.Alderton W. K., Cooper C. E., Knowles R. G.: Nitric oxide synthases: structure, function and inhibition. Biochem. J. 2001, 357, 593-615.
  • 3.Chen K., Pittman R. N., Popel A. S.: Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal. 2008, 10, 1185-1198.
  • 4.Dal-Ros S., Zoll J., Lang A. L., Auger C., Keller N., Bronner C., Geny B., Schini-Kerth V. B.: Chronic intake of red wine polyphenols by young rats prevents aging-induced endothelial dysfunction and decline in physical performance: role of NADPH oxidase. Biochem. Biophys. Res. Commun. 2011, 404, 743-749.
  • 5.Gaultier A., Arandjelovic S., Niessen S., Overton C. D., Linton M. F., Fazio S., Campana W. M., Cravatt B. F. 3rd, Gonias S. L.: Regulation of tumor necrosis factor receptor-1 and the IKK-NF-kappaB pathway by LDL receptor-related protein explains the antiinflammatory activity of this receptor. Blood 2008, 111, 5316-5325.
  • 6.Gryglewski R.: Nagroda Nobla w dziedzinie fizjologii za rok 1998. Med. Prakt. 1998, 12, 15-20.
  • 7.Harison D. G., Griending K. K.: Oxidative stress and hypertension, [w:] Ruth Weinberg Hypertension Primer: The Essential of High Blood Pressure American Heart Assocciation Basic Science, Population Science, and Clinical Management. Lippincott Wiliams&Wilkins, New York, Buffalo 2003, 185-189.
  • 8.Hattori Y., Hattori S., Wang X., Satoh H., Nakanishi N., Kasai K.: Oral administration of tetrahydrobiopterin slows the progression of atherosclerosis in apolipoprotein E-knockout mice. Arterioscler. Thromb. Vasc. Biol. 2007, 27, 865-870.
  • 9.Javeshghani D., Magder S.: Regional changes in constitutive nitric oxide synthase and the hemodynamic consequences of its inhibition in lipopolysaccharyde-treated pigs. Shock 2001, 16, 232-238.
  • 10.Kanai A. J., Mesaros S., Finkel M. S., Oddis C. V., Birder L. A., Malinski T.: β-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes. Am J. Physiol. 1997, 273, C1371-C1377.
  • 11.Kashiwagi S., Kajimura M., Yoshimura Y., Suematsu M.: Nonendothelial source of nitric oxide in arterioles but not in venules: alternative source revealed in vivo by diaminofluorescein microfluorography. Circ Res. 2002, 91, e55-e64.
  • 12.Kleinbongard P., Schulz R., Rassaf T., Lauer T., Dejam A., Jax T., Kumara I., Gharini P., Kabanova S., Ozuyaman B., Schnurch H. G., Godecke A., Weber A. A., Robenek M., Robenek H., Bloch W., Rosen P., Kelm M.: Red blood cells express a functional endothelial nitric oxide synthase. Blood 2006, 107, 2943-2951.
  • 13.Krzymowski T.: Fizjologia zwierz¹t. PWRiL, Warszawa 2005, 342-344.
  • 14.Leone A. M., Palmer R. M., Knowles R. G., Francis P. L., Ashton D. S., Moncada S.: Constitutive and inducible nitric oxide synthases intercorporate molecular oxygen into both nitric oxide and citrulline. J. Biol. Chem. 1991, 266, 23790-23795.
  • 15.Li H., Poulos T. L.: Structure-function studies on nitric oxide synthases. J. Inorganic Biochem. 2005, 99, 293-305.
  • 16.MacMicking J.: Nitric oxide and macrophage function. Annu. Rey. Immunol. 1997, 15, 323-350.
  • 17.Markos F., Snow H. M., Kidd C., Conlon K.: Nitric oxide facilitates vagal control of heart rate via actions in the cardiac parasympathetic ganglia of the anaesthetized dog. Exp. Physiol. 2001, 87, 49-52.
  • 18.Nalwaya N., Deen W. M.: Analysis of the effects of nitric oxide and oxygen on nitric oxide production by macrophages. J. Theor. Biol. 2004, 226, 409-419.
  • 19.Palmer R., Ashton D., Moncada S.: Vascular endothelial cells synthesise, nitric oxide from L-arginine. Nature 1988, 333, 664-666.
  • 20.Park C. S., Krishna G., Ahn M. S., Kang J. H., Chung W. G., Kim D. J., Hwang H. K., Lee J. N., Paik S. G., Cha Y. N.: Differential and constitutive expression of neuronal, infducible, and endothelial nitric oxide synthase mRNAs and proteins in pathologically normal human tissues. Nitric Oxide 2000, 4, 459-471.
  • 21.Poręba R., Derkacz A., Poręba M., Andrzejak R.: Funkcja śródbłonka u osób z chorobami układu krążenia. Część I: czynniki humoralne i badanie funkcji śródbłonka. Via Medica 2005, 4, 294-300.
  • 22.Rakhid R. D., Marber M. S.: Nitric oxide: an emerging role in cardioprotection? Heart 2001, 86, 368-372.
  • 23.Rubanyi G. M., Vanhoutte P. M.: Superoxide anions and hyperoxia inactivate endothelium - derived relaxing factor. Am. J. Physiol. 1986, 250, H822-H827.
  • 24.Shah A. M., Channon K. M.: Free radicals and redox signaling. In cardiovascular disease. Mini-Symposium. Heart 2004, 90, 486-487.
  • 25.Speyer C. L., Neff T. A., Warner R. L., Guo R.-F., Saema J. V., Riedmann N. C., Murphy M. E., Murphy H. S., Ward P. A.: Regulatory effects of iNOS on acute inflammatory response in mice. Am. J. Pathol. 2003, 163, 2319-2328.
  • 26.Toporsian M., Gividaraju M., Nagi K., Edelman D.: Down regulation of endothelial nitric oxide synthase in rat aorta after prolonged hypoxia in vitro. Circ. Res. 2000, 86, 671-675.
  • 27.Tsoukias V. M., Popel A. S.: A model of nitric oxide capillary exchange. Microcirc. 2003, 10, 479-495.
  • 28.Vaziri N. D., Ni Z., Oveisi F.: Upregulation of renal and vascular nitric oxide synthase in young spontancously hypertensive rats. Hypertension 1998, 31, 248-1254.
  • 29.Wang X., Hattori Y., Satoh H., Iwata C., Banba N., Monden T., Uchida K., Kamikawa Y., Kasai K.: Tetrahydrobiopterin prevents endothelial dysfunction and restores adiponectin levels in rats. Eur. J. Pharmacol. 2007, 555, 48-53.
  • 30.Wang Y., Kudo M., Xu M., Ayub A., Ashraf M.: Mitochondrial K(ATP) channel as an end effector of cardioprotection during late preconditioning: triggering role of nitric oxide. J. Mol. Cell Cardiol. 2001, 33, 2037-2046.
  • 31.Wever R. M. F., van Dam T., van Rijn H. J., de Groot F., Rabelink T. J.: Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase. Biochem. Res. Commun. 1997, 237, 340-344.
  • 32.Xie Y.-W., Shen W., Zhao G., Xu V., Wolin M. S., Hintze T. H.: Role of endothelium-derived nitric oxide in the modulation of canine myocardial mitochondrial respiration in vitro implication for the development of heart failure. Circ. Rec. 1996, 79, 381-387.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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