Sphingolipid biology, lipid rafts and their roles in neurodegeneration and neuroprotection

• Autorzy: Prinetti A.
• Języki publikacji: EN

Abstrakty

EN

Sphingolipids are polar membrane lipids present as minor components in eukaryotic cell membranes. Sphingolipids are highly enriched in nervous cells, where they exert important biological functions. They deeply affect the structural and geometrical properties and the lateral order of cellular membranes and modulate the function of several membrane- associated proteins. Sphingolipid metabolism is regulated along the differentiation and development of the nervous system, and the expression of a peculiar spatially and temporarily regulated sphingolipid pattern is essential for the maintenance of the functional integrity of the nervous system: sphingolipids in the nervous system participate to several signaling pathways controlling neuronal survival, migration and differentiation, responsiveness to trophic factors, synaptic stability and synaptic transmission, and neuron-glia interactions, including the formation and stability of central and peripheral myelin. In several neurodegenerative disease, sphingolipid metabolism is deeply deregulated, leading to the expression of abnormal sphingolipid patterns and altered membrane organization, that participate to several events related to the pathogenesis of these diseases. Targeting sphingolipid metabolism and lipid rafts organization represents today an underexploited but realistic opportunity to design novel therapeutic strategies for the intervention in this diseases.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S15

Twórcy

autor

Prinetti A.

• Department of Medical Biotechnology and Translational Medicine, University of Milan, Milan, Italy