The effect of insertion/deletion polymorphisms within the promoter and intron 1 sequences of the PRNP gene on the breeding value of Holstein-Friesian bulls

• Autorzy: Czarnik U. , Strychalski J. , Olenski K. , Barcewicz M. , Hering D. M. , Puckowska P. , Pierzchala M. , Urbanski P. , Pareek C. S.
• Języki publikacji: EN

Abstrakty

EN

The aim of this study was to verify the hypothesis that insertion/deletion (indel) polymorphisms within the promoter and intron 1 sequences of the prion protein (PRNP) gene can affect the breeding value of Holstein-Friesian bulls. The experimental material included 261 Holstein-Friesian bulls born between 1997 – 2002. It was shown that the polymorphism in the intron 1 (12 bp indel) sequence had a more significant effect on the analyzed traits than a polymorphism in the promotor (23 bp indel) sequence. A deletion allele within intron 1 (12del) significantly increased the bulls’ breeding value for milk yield (p=0.001), protein yield (p=0.042), type and conformation (p=0.018),udder width (p=0.003), dairy character (p=0.004), and decreased days open (p=0.022). A deletion allele (23del) at the polymorphic locus of the promoter significantly decreased the bulls’ breeding value for milk yield (p=0.001), udder width (p=0.029) and dairy character (p=0.033). Analysis of both alleles showed that 23del-12del haplotype increased the bulls’ breeding value for udder traits:udder (p=0.008), fore udder (p=0.043) and udder depth (p=0.041), and decreased for fat kontent (p=0.047) and conformation traits - body depth (p<0.001), chest width (p=0.029) and rear leg set - side view (p=0.029). Also positive effect of 23del-12ins haplotype for days open (p=0.003) and days between calving and first insemination (p=0.045) was observed.

Słowa kluczowe

EN

insertion; deletion; polymorphism; promoter; PRNP gene; prion protein; breeding value; animal breeding; Holstein-Friesian breed; bull

• Wydawca: -
• Czasopismo: Animal Science Papers and Reports
• Rocznik: 2015
• Tom: 33
• Numer: 1
• Opis fizyczny: p.13-22,ref.

Twórcy

autor

Czarnik U.

• Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Strychalski J.

• Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Olenski K.

• Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Barcewicz M.

• Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Hering D. M.

• Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Puckowska P.

• Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-719 Olsztyn, Poland

autor

Pierzchala M.

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland

autor

Urbanski P.

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, 05-552 Magdalenka, Poland

autor

Pareek C. S.

• Functional Genomics Laboratory, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland

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