Attachment-related pheromones in human: their effects on confidence during social interactions

• Autorzy: Pageat P. , Lecuelle C. , Cozzi A.
• Języki publikacji: EN

Abstrakty

EN

In 1999, our team has identified the first mammalian maternal appeasing pheromone, in sows and female dogs. We then identified a similar secretion that we have named HAP (Human Appeasing Pheromone), released by Montgomery glands from the areolae and a synthetic analogue of it was prepared. This paper describes the effects of HAP in children (18 to 36 months-old), experiencing a routine physical examination in a pediatric hospital. 100 children, 18 to 36 months old, presented for routine examination, have been enrolled in the Department of Pediatric Medicine of the Hospital of La Seyne-sur-Mer (France). The parents were informed about the study and after they accepted to participate in it, their children were enrolled in the study. Treatment, HAP or placebo, was allocated at random. The semiochemical was delivered by the mean of a tissue doll stuffed with a biopolymer (MaterBi®) containing 10% of synthetic HAP. Placebo doll were stuffed with pure MaterBi®. The doll was given 5 min before the examination. Two principle parameters were studied: the Mean Heart Rate (MHR), calculated from 5 measurements (waiting room, beginning and end of examination by the nurse, beginning and end of examination by the pediatrician); and the mean behavioural score (MBS from 0, easy examination, to 5 examination requires someone to help in controlling the child) measured in the same time as the heart rate. The groups were compared using Student t test for “age” and χ2 for “sex”. Having two principle parameters, a Bonferroni correction was applicable and the alpha risk was 2.5%. Two factors variance analysis (treatment and pediatrician) was used for MHR and MBS. For MBS, we also used Scheirer Ray Hare test. The two groups were comparable regarding sex and age. In HAP group, both MHR and MBS were very significantly lower (P<0.001) and this difference was confirmed using Scheirer Ray Hare test. Interaction between “pediatrician” and “treatment” was not significant. As observed in veterinary medicine with homologous maternal semiochemicals, the use of synthetic analogues of maternal odorous secretions, appears to be a promising technique. Both autonomic and behaviours are affected in presence of maternal semiochemicals, controlling the severity of the clinical signs displayed by patients facing stressing situations.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.350-351

Twórcy

autor

Pageat P.

• IRSEA Research Institute, Saint-Saturnin-les-Apt, France

autor

Lecuelle C.

• IRSEA Research Institute, Saint-Saturnin-les-Apt, France

autor

Cozzi A.

• IRSEA Research Institute, Saint-Saturnin-les-Apt, France