Antiviral resistance of splenocytes in aged mice

• Autorzy: Zaczynska E. , Artym J. , Kocieba M. , Burster T. , Kruzel M. , Paprocka M. , Zimecki M.
• Języki publikacji: EN

Abstrakty

EN

We compared the susceptibility to viral infection of splenocytes, isolated from young versus old CBA mice, and evaluated the antiviral actions of lactoferrin in splenocytes infected with Encephalomyocarditis virus (EMCV). Recombinant mouse lactoferrin (rmLF) and bovine lactoferrin (bLF) were used. There were no differences in the susceptibility to EMCV infection in the studied age categories. Both types of lactoferrins were protective in young and old mice. The study confirmed the undisturbed viral resistance in old mice and the protective actions of lactoferrin in viral infection. The antiviral action of the homologous mouse lactoferrin was demonstrated for the first time.

• Wydawca: -
• Czasopismo: Polish Journal of Microbiology
• Rocznik: 2017
• Tom: 66
• Numer: 1
• Opis fizyczny: p.131-134,fig.,ref.

Twórcy

autor

Zaczynska E.

• Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

autor

Artym J.

• Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

autor

Kocieba M.

• Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

autor

Burster T.

• Department of Neurosurgery, Ulm University Medical Centre, Ulm, Germany

autor

Kruzel M.

• Houston Medical School, University of Texas, Houston, TX, USA

autor

Paprocka M.

• Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

autor

Zimecki M.

• Department of Experimental Therapy, Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland

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Identyfikatory

DOI

10.5604/17331331.1235002