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2012 | 11 | 1 |
Tytuł artykułu

Critical issues related to transfersomes – novel vesicular system

Treść / Zawartość
Warianty tytułu
PL
Transferosomy – nowy system transportu leków
Języki publikacji
EN
Abstrakty
EN
It has become increasingly apparent that vesicular drag delivery elicits modest possessions in drag targeting. Transfersomes are a form of elastic or deformable vesicle, which were first introduced in the early 1990s. Elasticity can be achieved by using an edge activator in the lipid bilayer stracture. Molecules greater than 500 Da normally do not cross the skin. This prevents epicutaneous delivery of the high molecular weight therapeutics as well as non-invasive trans-cutaneous immunisation. Transdermal route will always remain a lucrative area for drag delivery. With the advent of new categories of drugs like peptides this route has captured more focus to combat the problems related to their delivery through oral route. But the transdermal route is equally filled with the hopes and disappointments as the transport of drag through this route faces many problems especially for the large molecules. To answer this problem many approaches were adopted. One of the very recent approaches is the use of ultra-defonnable carrier systems (transfersomes). They have been used as drag carriers for a range of smali molecules, peptides, proteins and vaccines, both in vitro and in vivo. Transfersomes penetrate through the pores of stratum comeum which are smaller than its size and get into the underlying viable skin in intact form. This is because of its deformable nature. The aim of this article is explanation the formation of micelle and vesicles, various types of vesicles, specifically focusing on transfersomes.
PL
Wydaje się, że obecnie transport liposomowy nie jest zbyt wykorzystywany do celowego dostarczania leków. Transferosomy to rodzaj elastycznych i deformowalnych liposomów, które po raz pierwszy wprowadzono we wczesnych latach dziewięćdziesiątych ubiegłego wieku. Elastyczność struktury uzyskano, stosując aktywatory w zewnętrznej strukturze dwuwarstwy lipidowej. Cząsteczki o masie większej niż 500 Da nie przechodzą przez skórę. Zapobiega to dostarczaniu wysokocząsteczkowych leków przez naskórek oraz nieinwazyjnemu szczepieniu przezskómemu. Bezpośredni transport przez skórę jest najlepszym sposobem dostarczania leków. Wraz z pojawianiem się nowych kategorii leków, np. peptydów, dostarczanie leków przez skórę budzi coraz większe zainteresowanie, między innymi dzięki uniknięciu problemów występujących w dawkowaniu doustnym. Dostarczanie przez skórę wiąże się z wieloma nadziejami i rozczarowaniami, szczególnie w odniesieniu do dużych molekuł. Aby przezwyciężyć problemy, podjęto wiele badań w celu ich rozwiązania. Jednym z ostatnio stosowanych sposobów jest wykorzystanie super deformowalnych systemów transportu - transferosomów. Używane są one jako transportery wielu małych cząsteczek, peptydów, białek i szczepionek, zarówno in vivo, jak i in vitro. Tranferosomy penetrują pory stratum comeum, które są mniejsze od wymiarów samych transferosomów, a dzięki elastycznej naturze dostają się do głębszych warstw skóry w formie niezmienionej. Celem pracy jest wyjaśnienie powstawania miceli oraz różnego rodzaju liposomów ze szczególnym uwzględnieniem transferosomów.
Wydawca
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Rocznik
Tom
11
Numer
1
Opis fizyczny
p.67-82,fig.,ref.
Twórcy
autor
  • HOD, Department of Pharmaceutics, Nalanda College of Pharmacy, Hyderabad Main Road, Nalgonda 508001, A.P., India
autor
autor
autor
autor
autor
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