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2015 | 75 | Supl. |
Tytuł artykułu

Valproic acid but not minocycline alleviates striatal neuron degeneration in the rat model of nitracerebral hematoma

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
BACKGROUND AND AIMS: The study evaluates the effect of experimentally induced intracerebral haematoma (ICH) on density of neurodegenerating neurons and volume of the rat striatum. In addition, we studied how administration of valproic acid and minocycline, the two drugs generally believed to be neuroprotective agents, influences the density of these neurons. METHODS: 80 adult male Wistar rats were assign to one of 4 experimental groups: control, (CON), haematoma (HAEM), haematoma and minocycline (MINO) and haematoma and valproic acid (VAL). Five animals from each experimental group were sacrificed at four time points: 2 weeks, 4 weeks, 24 weeks and 48 weeks after ICH. To assess the neurodegeneration the sections were stained with FluoroJadeB (FJB). The CellSense Dimension 1.5 (Olympus, Japan) image analysis system was employed to measure the densities of FJB-labelled neurons as well as volume of the striatum. Statistical analyses were performed using two way ANOVA with replications. To find differences between groups post-hoc Tukey test was applied. A P-value <0.05 was considered significant. RESULTS: Our study revealed that valproic acid treatment decreased the density of FJB-labeled degenerating neurons 4 weeks after ICH induction in the ipsilateral striatum. Minocycline did not have such effect. None of the two drugs influenced the volume of the striatum. CONCLUSIONS: Our study revealed that valproic acid alleviates striatal neuron degeneration in the rat model of ICH. Because striatum has been implicated to play role in motor control as well as cognition and affective control, the valproic acid treatment might have beneficial effects on these processes after ICH.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
75
Numer
Opis fizyczny
p.S99-S100
Twórcy
autor
  • Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland
autor
  • Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland
  • Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland
autor
  • Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland
autor
  • Department of Anatomy and Neurobiology, Medical University of Gdansk, Gdansk, Poland
Bibliografia
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-40bf19d5-5c33-4b1c-92e5-f6bab6f9a166
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