The role of toll-like receptor agonists in the immunotherapy of leishmaniosis. An update and proposal for a new form of anti-leishmanial therapy

• Autorzy: Dasgupta S. , Aghazadeh-Dibavar S. , Bandyopadyay M.
• Języki publikacji: EN

Abstrakty

EN

The use of toll-like receptor agonists in immunotherapy is a new approach in the prevention of immunosuppression during fatal Leishmania parasite infection. The objective of such immunotherapy is to activate specific cell-mediated immune responses, macrophage activation and antigen-responsive inflammation, to kill intracellular amastigotes. Toll-like receptor agonist-based treatment in immunocompetent hosts can be effective either by selective use of the agonists alone or in combination with the anti-leishmanial drug stibanate. Recent investigations suggest that toll-like receptor signal pathways constitute a possible new mode of anti-leishmanial treatment. This article describes the prospect of toll-like receptor – mediated signal pathways in the immunotherapy of cutaneous and visceral leishmaniosis, as well as post kala-azar dermal leishmaniosis (PKADL), a skin-sequel of visceral infection. Suitable synthetic agonists need to be developed for toll-like receptors to overcome immunosuppression.

Słowa kluczowe

EN

toll-like receptor; immune response; immunotherapy; leishmaniasis; new form; therapy; parasitic infection; Leishmania

• Wydawca: -
• Czasopismo: Annals of Parasitology
• Rocznik: 2014
• Tom: 60
• Numer: 2
• Opis fizyczny: p.75-82,fig.,ref.

Twórcy

autor

Dasgupta S.

• Department of Microbiology and Immunology, Saint James School of Medicine (Anguilla Campus), Albert Lake Drive, The Quarter, A-I-2640, P.O.Box 318, Anguilla

autor

Aghazadeh-Dibavar S.

• Department of Microbiology and Immunology, Saint James School of Medicine (Anguilla Campus), Albert Lake Drive, The Quarter, A-I-2640, P.O.Box 318, Anguilla

autor

Bandyopadyay M.

• Storm Eye Institute, Medical University of South Carolina, 171 Ashley Avenue, Charleston, South Carolina 29425, USA

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