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2010 | 70 | 3 |
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Chronic intermittent hypoxia exposure induces memory impairment in growing rats

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The study was aimed to examine the effect of chronic intermittent hypoxia (CIH) on spatial memory of growing rats and to explore the possible underlying mechanisms. Sixty two rats were trained to perform the 8-Arm radial maze task and were divided into four groups: 2-week-CIH (2IH), 2-week-control (2C), 4-week-CIH (4IH) and 4-week-control (4C). There were more reference memory errors, working memory errors and total memory errors in 2IH and 4IH groups compared to the controls. The levels of 8-iso-Prostaglandin F2α (8-ISO-PGF2α), an in vivo marker for oxidative stress, in serum, hippocampus and prefrontal cortex were higher in CIH groups than the control groups. There were significant correlations between the levels of 8-ISO-PGF2α and numbers of memory errors. The ultrastructural changes were evident in the hippocampal and prefrontal cortical tissues from the CIH groups. These results indicate that CIH can induce oxidative stress in brain tissues involved in spatial memory function.
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  • Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical College, Wenzhou, China
  • Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical College, Wenzhou, China
  • Jining First People’s Hospital, Jining, Shandong Province, China
  • Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou, China
  • Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou, China
  • Department of Pediatrics, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical College, Wenzhou, China
  • Center of Neurology and Rehabilitation, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical College, Wenzhou, China
  • Institute of Cor Pulmonale, Wenzhou Medical College, Wenzhou, China
  • Ali NJ, Pitson D, Stradling JR (1996) Sleep disordered breathing: effects of adenotonsillectomy on behaviour and psychological functioning. Eur J Pediatr 155: 56-62.
  • Ali NJ, Pitson D, Stradling JR (1993) Snoring, sleep distur­bance, and behaviour in 4-5 year olds. Arch Dis Child 68: 360-366.
  • Anuntaseree W, Kuasirikul S, Suntornlohanakul S (2005) Natural history of snoring and obstructive sleep apnea in Thai school-age children. Pediatr Pulmonol 39: 415­420.
  • Beebe DW, Wells CT, Jeffries J, Chini B, Kalra M, Amin R (2004) Neuropsychological effects of pediatric obstruc­tive sleep apnea. J Int Neuropsychol Soc 10: 962-975.
  • Blunden S, Lushington K, Kennedy D, Martin J, Dawson D (2000) Behavior and neurocognitive performance in chil­dren aged 5-10 years who snore compared to controls. J Clin Exp Neuropsychol 22: 554-568.
  • Brunetti L, Rana S, Lospalluti ML, Pietrafesa A, Francavilla R, Fanelli M, Armenio L (2001) Prevalence of obstructive sleep apnea syndrome in a cohort of 1,207 children of southern Italy. Chest 120: 1930-1935.
  • Calhoun SL, Mayes SD, Vgontzas AN, Tsaoussoglou M, Shifflett LJ, Bixler EO (2009) No relationship between neurocognitive functioning and mild sleep disordered breathing in a community sample of children. J Clin Sleep Med 5: 228-234.
  • Debiec J, LeDoux JE, Nader K (2002) Cellular and systems reconsolidation in the hippocampus. Neuron 36: 527­538.
  • Dyugovskaya L, Lavie P, Lavie L (2002) Increased adhesion molecules expression and production of reactive oxygen species in leukocytes of sleep apnea patients. Am J Respir Crit Care Med 165: 934-939.
  • Gozal D (1998) Sleep-disordered breathing and school per­formance in children. Pediatrics 102: 616-620.
  • Gozal D, Daniel JM, Dohanich GP (2001) Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. J Neurosci 21: 2442-2450.
  • Gozal E, Gozal D, Pierce WM, Thongboonkerd V, Scherzer JA, Sachleben LRJr, Brittian KR, Guo SZ, Cai J, Klein JB (2002) Proteomic analysis of CA1 and CA3 regions of rat hippocampus and differential susceptibility to intermit­tent hypoxia. J Neurochem 83: 331-345.
  • Guilleminault C, Winkle R, Korobkin R, Simmons B (1982) Children and nocturnal snoring: evaluation of the effects of sleep related respiratory resistive load and daytime functioning. Eur J Pediatr 139: 165-171.
  • Halbower AC, Degaonkar M, Barker PB, Earley CJ, Marcus CL, Smith PL, Prahme MC, Mahone EM (2006) Childhood obstructive sleep apnea associates with neuropsychological deficits and neuronal brain injury. PLoS Med 3:1391-1402.
  • Halliwell B, Chirico S (1993) Lipid peroxidation: its mecha­nism, measurement, and significance. Am J Clin Nutr 57: 715S-725S.
  • Hodges H (1996) Maze procedures: the radial-arm and water maze compared. Brain Res Cogn Brain Res 3: 167-181.
  • Kheirandish L, Gozal D, Pequignot JM, Pequignot J, Row BW (2005) Intermittent hypoxia during development induces long-term alterations in spatial working memory, monoamines, and dendritic branching in rat frontal cor­tex. Pediatr Res 58: 594-599.
  • McGuire M, MacDermott M, Bradford A (2002) The effects of chronic episodic hypercapnic hypoxia on rat upper airway muscle contractile properties and fiber-type distri­bution. Chest 122: 1400-1406.
  • Morrow JD, Hill KE, Burk RF, Nammour TM, Badr KF, Roberts LJ 2nd (1990) A series of prostaglandin F2-like compounds are produced in vivo in humans by a non- cyclooxygenase, free radical-catalyzed mechanism. Proc Natl Acad Sci USA 87: 9383-9387.
  • Morrow JD, Roberts LJ 2nd (1999) Mass spectrometric quan­tification of F2-isoprostanes in biological fluids and tissues as measure of oxidant stress. Methods Enzymol 300: 3-12.
  • Nicolle MM, Gonzalez J, Sugaya K, Baskerville KA, Bryan D, Lund K, Gallagher M, McKinney M (2001) Signatures of hippocampal oxidative stress in aged spatial learning- impaired rodents. Neuroscience 107: 415-431.
  • Owens J, Spirito A, Marcotte A, McGuinn M, Berkelhammer L (2000) Neuropsychological and behavioral correlates of obstructive sleep Apnea syndrome in children: a prelimi­nary study. Sleep Breath 4: 67-78.
  • Polotsky VY, Rubin AE, Balbir A, Dean T, Smith PL, Schwartz AR, O'Donnell CP (2006) Intermittent hypoxia causes REM sleep deficits and decreases EEG delta power in NREM sleep in the C57BL/6J mouse. Sleep Med 7: 7-16.
  • Prabhakar NR (2001) Oxygen sensing during intermittent hypoxia: cellular and molecular mechanisms. J Appl Physiol 90: 1986-1994.
  • Rhodes SK, Shimoda KC, Waid LR, O'Neil PM, Oexmann MJ, Collop NA, Willi SM (1995) Neurocognitive deficits in morbidly obese children with obstructive sleep apnea. J Pediatr 127: 741-744.
  • Roberts LJ, Morrow JD (2000) Measurement of F(2)- isoprostanes as an index of oxidative stress in vivo. Free Radic Biol Med 28: 505-513.
  • Row BW, Kheirandish L, Neville JJ, Gozal D (2002) Impaired spatial learning and hyperactivity in developing rats exposed to intermittent hypoxia. Pediatr Res 52: 449-453.
  • Row BW, Liu R, Xu W, Kheirandish L, Gozal D (2003) Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. Am J Respir Crit Care Med 167: 1548-1553.
  • Schlaud M, Urschitz MS, Urschitz-Duprat PM, Poets CF (2004) The German study on sleep-disordered breathing in primary school children: epidemiological approach, repre­sentativeness of study sample, and preliminary screening results. Paediatr Perinat Epidemiol 18: 431-440.
  • Schulz R, Mahmoudi S, Hattar K, Sibelius U, Olschewski H, Mayer K, Seeger W, Grimminger F (2000) Enhanced release of superoxide from polymorphonuclear neutro- phils in obstructive sleep apnea. Impact of continuous positive airway pressure therapy. Am J Respir Crit Care Med 162: 566-570.
  • Stradling JR, Thomas G, Warley AR, Williams P, Freeland A (1990) Effect of adenotonsillectomy on nocturnal hypox- aemia, sleep disturbance, and symptoms in snoring chil­dren. Lancet 335: 249-253.
  • Xu W, Chi L, Row BW, Xu R, Ke Y, Xu B, Luo C, Kheirandish L, Gozal D, Liu R (2004) Increased oxida- tive stress is associated with chronic intermittent hypox- ia-mediated brain cortical neuronal cell apoptosis in a mouse model of sleep apnea. Neuroscience 126: 313­323.
  • Zou LB, Yamada K, Nabeshima T (1998) Sigma receptor ligands (+)-SKF10,047 and SA4503 improve dizocilpine- induced spatial memory deficits in rats. Eur J Pharmacol 355: 1-10.
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