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1989 | 40 | 2 |

Tytuł artykułu

Pressor responsiveness to vasopressin in spontaneously hypertensive rats

Treść / Zawartość

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Stępniakowski, K., Łapiński, М., Januszewicz, A. Noszczyk, В. and Szcze- pańska-Sadowska, E.: Pressor responsiveness to vasopressin in spontaneously hypertensive rats. Acta physiol, pol., 1989, 40 (2): 171-182, The present study was designed to find out whether pressor responsiveness to vasopressin (AVP) is altered in spontaneously hypertensive rats (SHR) in comparison with their normotensiye controls (WKY). Blood pressure and heart rate changes after injection of graded doses of 2.5, 5.0 and 10.0 ng of AVP (Calbiochem) i.v. were compared in 9 conscibus, unrestrained spontaneously hypertensive (SHR) and 11 normotensive Wistar Kyoto (WKY) rats, chronically instrumented with venous and arterial catheters. The threshold dose necessary to elicit a significant increase in blood pressure and reduction of heart rate was lower in WKY than in SHR. At each dose level the blood pressure elevation persisted for a longer period in WKY than in SHR. Bradycardia was greater in WKY than in SHR both in absolute terms and in relation to the blood pressure increase. Thus, the results reveal diminished pressor responsiveness to moderate doses of AVP in SHR in spite of suppressed reflex bradycardia. It is suggested that the peripheral action of AVP on the vascular system is attenuated in SHR.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

40

Numer

2

Opis fizyczny

p.171-182,fig.,ref.

Twórcy

  • Department of Clinic of Hypertension and Angiology, School of Medicine, Warsaw, Poland
autor
  • Department of Clinic of Hypertension and Angiology, School of Medicine, Warsaw, Poland
  • Department of Clinic of Hypertension and Angiology, School of Medicine, Warsaw, Poland
autor
  • Department of Clinical and Applied Physiology, School of Medicine, Warsaw, Poland
  • Department of Clinical and Applied Physiology, School of Medicine, Warsaw, Poland

Bibliografia

  • 1. Bennet, T., Gardiner, S. M. (1985) Involvement of vasopressin in cardiovascular regulation. Cardiovasc. Res. 19. 57-68.
  • 2. Berecek, K. H., Murray, R. D., Gross, F., Brody, M. J. (1982) Vasopressin and Vascular reactivity in the development of DOCA hypertension in rats with hereditary diabetes insipidus. Hypertension 4. 3-12.
  • 3. Bie, P., Warberg, J. (1983) Effects on intravascular pressures of vasopressin and angiotensin II in dogs. Am. J. Physiol. 245. R906-R914.
  • 4. Bonjour, J. P., Malvin, R. Ł. (1970) The concentrations of ADH in conscious and anesthetized dogs. Am. J. Physiol. 218. 1128-1132.
  • 5. Boyle, W. A., Segel, L. (1986) Direct cardiac effects of vasopressin and their reversal by a vascular antagonist. Am. J. Physiol. 251. H734-H741.
  • 6. Cowley, A. W., Liard, J. F., Skelton, M. M., Quillen, E. W., Osborn, J. W., Webb, R. L. (1985) Vasopressin-neural interactions in the control of cardiovascular function. In: Vasopressin. Ed. R. W. Schrier, Raven Press, New York, pp. 1-10.
  • 7. Cowley, A. W., Monos, E., Guyton, A. C. (1974) Interaction of vasopressin and the baroreceptor reflex system in the regulation of arterial blood pressure in the dog. Circulation Res. 34. 505-514.
  • 8. Cox, R. H., Bagshaw, R. J, (1980) Effects of anesthesia on carotid sinus reflex control of arterial hemodynamics in the dog. Am, J. Physiol. 289. H681-H691.
  • 9. Crofton, J. T., Share, L., Baer, P. G., Allen, С. M., Wang, В. C. (1981) Vasopressin secretion in the New Zealand genetically hyperttemsttive rat. Clin. Expil Hypertension 3. 975-989.
  • 10. Crofton, J., Share, J., Shade, R. E., Allen, C.t Tarnowski, D. (1978) Vasopressin in the rat with spontaneous hypertension. Am. J. Physiol. 235. H361-H366.
  • 11. Crofton, J. T., Share, L., Wang, В. C., Shade, R. E. (1980) Pressor responsiveness to vasopressin in the rat with DOC-salt hypertension. Hypertension 2. 424-431.
  • 12. Filep, J., Frölich, J. C., Fejes-Toth, G. (1985) Evidence against; a vasopressor role of ADH in malignant DOC-salt hypertension. Clin. Exp. Hypertension.Part A 7 (10), 1457-1470.
  • 13. Gauquelin, G., Gharib, C., Vincent, M., Allevard, A. M., Sempore, В., Benzoni, D., Sassard, J. (1984) Vasopressin and oxytocin in genetically hypertensive rats of the Lyon strain. Hypertension 6. 94-98.
  • 14. Gonzalez, E. R., Krieger, A. J., Sapru, H. N. (1983) Central resetting of baroreflex in the spontaneously hypertensive rat. Hypertension 5. 346-352.
  • 15. Hoffman, W. E., Phillips, M. J., Schmid, P. G, (1977) Central angiotensin II-induced responses in spontaneously hypertensive rats. Am. J. Physiol. 232. H426-H433.
  • 16. Izdebska, E., Jodkowski, J., Trzebski, A. (1982) Central influence of vasopressin on baroreceptor reflex in normotensive rats and its lack in spontaneously hyper- tensive rats (SHR). Experientia 38. 594-595.
  • 17. Matsuguchi, H., Schmid, P. G. (1982) Pressor response to vasopressin and impaired baroreflex - function in DOC-salt hypertension. Am. J. Physiol. 242. H44-H49.
  • 18. Matsuguchi, H., Schmid, P. G., Van Orden, D., Mark, A. L. (1981) Does vasopressin contribute to salt-induced hypertension in the Dahl-strain? Hypertension 3. 174-181.
  • 19. Möhring, J. (1976) Neurohypophyseal vasopressor principle: Vasopressor hormone as well as anfcidiuretic hormone? Klin. Wochen schr. 56 (Suppl. I). 71-79.
  • 20. Möhring, J., Kintz, J., Schoun, J. (1979) Studies on the role of vasopressin in blood pressure control of spontaneously hypertensive rats with established hypertension (SHR, stroke-prone strain). J. Cardiovasc. Pharmacol. 1. 593-608.
  • 21. Montani, J. P. Liard, J. W., Schoun, J., Möhring, J. (1980) Hemodynamic effects of exogenous and endogenous vasopressin at low plasma concentrations in conscious dogs. Circulation Res. 47. 346-355.
  • 22. Nosaka, S., Wang, S. C. (1972) Carotid sinus baroreceptor functions in the spontaneously hypertensive rat. Am. J. Physiol. 222. 1079-1084.
  • 23. Padfield, Р. L., Brown, J. J., Lever, A. F., Morton, J. J., Robertson, J. J. S. (1981) Does vasopressin play a role in pathogenesis of hypertension. Clin. Sci. 61. 141s-143s.
  • 24. Sapru, N. H., Wang, S. C. (1976) Modification of aortic baroreceptor resetting in the spontaneously hypertensive rat. Am. J. Physiol. 230. 664-674.
  • 25. Schwartz, J., Liard, J. F., Ott, C., Cowley, A. W. (1985) Hemodynamic effects of neurohypophyseal peptides with antidiuretic activity in dogs. Am. J. Physiol. 249. H1001-Hl008.
  • 26. Share, L., Crofton, J. T. (1984) The role of vasopressin in hypertension. Federation Proc. 43. 103-106.
  • 27. Simon-Oppermann, С., Сrау, D., Szczepańska-Sadowska, E., Simon, E. (1983) Vasopressin in blood and third ventricle CSF of dogs in chronic experiments. Am. J. Physiol. 255. R541-R548.
  • 28. Szczepańska-Sadowska, E. (1973) Hemodynamic effects of a moderate increase of the plasma vasopressin level in conscious dogs. Pflügers Arch. 338. 313-322.
  • 29. Winer, B. J. (1970) Statistical Principles in Experimental Design. McGraw-Hill, New York, pp. 46-139 and 299-378.
  • 30. Wyse, D. G. (1985) In vitro arterial response to vasopressin in subjects with a family history of hypertension. Hypertension 7. 211-215.
  • 31. Zarr, J. H. (1974) Biostatlstical Analysis. Englewood Cliffs, Prentice Hall Inc., New York, pp. 198-251.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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