Pressor responsiveness to vasopressin in spontaneously hypertensive rats

• Autorzy: Stepniakowski K. , Lapinski M. , Januszewicz A. , Noszczyk B. , Szczepanska-Sadowska E.
• Języki publikacji: EN

Abstrakty

EN

Stępniakowski, K., Łapiński, М., Januszewicz, A. Noszczyk, В. and Szcze- pańska-Sadowska, E.: Pressor responsiveness to vasopressin in spontaneously hypertensive rats. Acta physiol, pol., 1989, 40 (2): 171-182, The present study was designed to find out whether pressor responsiveness to vasopressin (AVP) is altered in spontaneously hypertensive rats (SHR) in comparison with their normotensiye controls (WKY). Blood pressure and heart rate changes after injection of graded doses of 2.5, 5.0 and 10.0 ng of AVP (Calbiochem) i.v. were compared in 9 conscibus, unrestrained spontaneously hypertensive (SHR) and 11 normotensive Wistar Kyoto (WKY) rats, chronically instrumented with venous and arterial catheters. The threshold dose necessary to elicit a significant increase in blood pressure and reduction of heart rate was lower in WKY than in SHR. At each dose level the blood pressure elevation persisted for a longer period in WKY than in SHR. Bradycardia was greater in WKY than in SHR both in absolute terms and in relation to the blood pressure increase. Thus, the results reveal diminished pressor responsiveness to moderate doses of AVP in SHR in spite of suppressed reflex bradycardia. It is suggested that the peripheral action of AVP on the vascular system is attenuated in SHR.

• Wydawca: -
• Czasopismo: Acta Physiologica Polonica
• Rocznik: 1989
• Tom: 40
• Numer: 2
• Opis fizyczny: p.171-182,fig.,ref.

Twórcy

autor

Stepniakowski K.

• Department of Clinic of Hypertension and Angiology, School of Medicine, Warsaw, Poland

autor

Lapinski M.

• Department of Clinic of Hypertension and Angiology, School of Medicine, Warsaw, Poland

autor

Januszewicz A.

• Department of Clinic of Hypertension and Angiology, School of Medicine, Warsaw, Poland

autor

Noszczyk B.

• Department of Clinical and Applied Physiology, School of Medicine, Warsaw, Poland

autor

Szczepanska-Sadowska E.

• Department of Clinical and Applied Physiology, School of Medicine, Warsaw, Poland

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