Lutein and zeaxanthin - radio- and chemoprotective properties. Mechanism and possible use

• Autorzy: Fiedorowicz J. , Dobrzynska M.M.
• Języki publikacji: EN

Abstrakty

EN

Lutein and zeaxanthin are naturally occurring xanthophylls, mainly present in green, leafy vegetables and egg’s yolk. Their presence is connected with blue spectrum light absorbance, including UV. This property, and fact, that these xanthophylls are accumulated by human eye’s macula, leads to eye’s protective functions of them including protection from age-related macular degeneration (AMD). Also, antioxidative features of lutein and zeaxanthin are boosting overall health of human body. Numerous studies proves anti-inflammatory and protective attributes of these compounds, based on many, different mechanisms. One of them is regulating redox potential in cells, and impact on expression of linked genes. In preventing of eye diseases, an important gene that is regulated by lutein and zeaxanthin is the Nrf2 gene, whose increased activity leads to optimizing the cellular response to reactive oxygen species (ROS) and preventing related diseases. Other research confirms antiproliferative properties of mentioned compounds in case of certain human cancer cell lines. There are e.g.: HepG2 (hepatitis cancer), MCF-7 (breast cancer), which treated in vitro with lutein solution showed reduction of cell growth. Lutein alone, during in vivo studies conducted on mice, exhibited also radioprotective properties, positively affecting the vitality of animals. Lutein provides also increasing of tolerance to UV radiation, reducing inflammatory processes in the skin and preventing oncogenesis. Low intake of lutein and zeaxanthin, associated with “western diet”, rich in simple carbohydrates and processed food, common in developed countries, including Poland, is linked with diabetes and obesity incidence. Assuming, lutein and zeaxanthin significantly affect the well-being of the human body, and their appropriate amount in diet can help reduce risk of many diseases. For supplementation, the optimized dosage of these xanthophylls includes doses of 10 mg for lutein and 2 mg for zeaxanthin, and it is recommended to consume along with fats or meals rich in fats.

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2023
• Tom: 74
• Numer: 3
• Opis fizyczny: p.257-264,fig.,ref.

Twórcy

autor

Fiedorowicz J.

• Department of Radiation Hygiene and Radiobiology, National Institute of Public Health NIH - National Research Institute, Chocimska Street 24, 00-791 Warsaw, Poland

autor

Dobrzynska M.M.

• Department of Radiation Hygiene and Radiobiology, National Institute of Public Health NIH - National Research Institute, Chocimska Street 24, 00-791 Warsaw, Poland

Bibliografia

• 1. Aziz E., Batool R., Akhtar W., Rehman S. Shahzad T., Malik A., Shariati M.A., Laishevtcev A., Plygun S., Heydari M,, Rauf A., Shaheer Arif, A.: Xanthophyll: Health benefits and therapeutic insights. Life Sci 2020; 240:117104, ISSN 0024-3205, https://doi.org/10.1016/j.lfs.2019.117104.
• 2. Azqueta A., Shaposhnikov S., Collins A.R.: DNA oxidation: Investigating its key role in environmental mutagenesis with the comet assay. Mutat Res/Genetic Toxicol Environ Mutagen 2009;674(1–2):101-108. https://doi.org/10.1016/j.mrgentox.2008.10.013.
• 3. Bellezza I.: Oxidative Stress in Age-Related Macular Degeneration: Nrf2 as Therapeutic Target. Frontiers in pharmacology, 2018;9:1280 , https://doi.org/10.3389/fphar.2018.01280.
• 4. Borel, P., de Edelenyi, F. S., Vincent-Baudry, S., Malezet-Desmoulin, C., Margotat, A., Lyan, B., Gorrand J.M., Meunier M., Drouault-Holowacz S.,Bieuvelet, S.: Genetic variants in BCMO1 and CD36 are associated with plasma lutein concentrations and macular pigment optical density in humans. Ann Med 2010;43(1):47–59. doi:10.3109/07853890.2010.531757.
• 5. Borel, P., Desmarchelier, C., Nowicki, M., Bott, R., Morange, S., & Lesavre, N.: Interindividual variability of lutein bioavailability in healthy men: characterization, genetic variants involved, and relation with fasting plasma lutein concentration. Am J Clin Nutr 2014;100(1):168-175. doi:10.3945/ajcn.114.085720.
• 6. During A., Dawson H.D., Harrison E.H.: Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 cells treated with ezetimibe. J Nutr. 2005;135(10):2305-12. doi: 10.1093/jn/135.10.2305.PMID: 16177187.
• 7. During A., Doraiswamy S., Harrison E.H.: Xanthophylls are preferentially taken up compared with beta-carotene by retinal cells via a SRBI-dependent mechanism. J Lipid Res 2008;49(8):1715-1724. doi:10.1194/jlr.M700580-JLR200.
• 8. Elvira-Torales L.I., García-Alonso J., Periago-Castón M.J.: Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review. Antioxidant. 2019;8(7):229. https://doi.org/10.3390/antiox8070229.
• 9. Erdman J.W. Jr., Smith J.W., Kuchan M.J., Mohn E.S., Johnson E.J., Rubakhin S.S., Wang L., Sweedler J.V., Neuringer M.: Lutein and Brain Function. Foods 2015;4(4):547-564. https://doi.org/10.3390/foods4040547.
• 10. Feng L., Nie K., Jiang H., Fan W.: Effects of lutein supplementation in age-related macular degeneration. PLOS ONE 2019;14(12):e0227048. https://doi.org/10.1371/journal.pone.0227048.
• 11. Ferguson L.: Natural and man-made mutagens and carcinogens in the human diet. Toxicology, 2003; 181-182. 79-82. 10.1016/S0300-483X(02)00258-5.
• 12. Giordano E., Quadro L.: Lutein, zeaxanthin and mammalian development: Metabolism, functions and implications for health. Arch Biochem Biophys 2018;647:33-40. doi:10.1016/j.abb.2018.04.008.
• 13. Grether-Beck, S., Marini, A., Jaenicke, T., Stahl, W. and Krutmann, J.: Molecular evidence that oral supplementation with lycopene or lutein protects human skin against ultraviolet radiation: results from a double-blinded, placebo-controlled, crossover study. Br J Dermatol 2017;176:1231-1240.
• 14. Hamułka J., Koczara J., Gronek M.: Lutein content of selected polish foods and estimation of its intake. Polish J Food Nutr Sci 2005;55(2):201-206.
• 15. Hamułka J., Sulich A., Zielińska M., Wawrzyniak A. Assessment of carotenoid intake in a selected group of pregnant women. Probl Hig Epidemiol 2015;96(4):763-768.
• 16. He, RR., Tsoi, B., Lan, F., Yo N., Yo X.-S.,Kurihara H.: Antioxidant properties of lutein contribute to the protection against lipopolysaccharide-induced uveitis in mice. Chin Med, 2011;6:38. https://doi.org/10.1186/1749-8546-6-38.
• 17. Hojnik M., Škerget M., Knez Z.: Extraction of lutein from Marigold flower petals – Experimental kinetics and modelling. LWT - Food Sci Technol 2008;41(10):2008-2016, ISSN 0023-6438, https://doi.org/10.1016/j.lwt.2007.11.017.
• 18. Johnson E.J., McDonald K., Caldarella SM., Chung HY., Troen AM., Snodderly DM.: Cognitive findings of an exploratory trial of docosahexaenoic acid and lutein supplementation in older women. Nutr Neurosci 2008;11(2):75-83. doi: 10.1179/147683008X301450.PMID: 18510807.
• 19. Kavalappa, Y.P., Gopal, S.S., Ponesakki, G.: Lutein inhibits breast cancer cell growth by suppressing antioxidant and cell survival signals and induces apoptosis. J Cell Physiol 2021;236:1798– 1809. https://doi.org/10.1002/jcp.29961.
• 20. Lakshminarayana R., Raju M., Krishnakantha T.P. & Baskaran V.: Lutein and zeaxanthin in leafy greens and their bioavailability olive oil influences the absorption of dietrary lutein and accumulation in adult rats. J. Agricul Food Chem 2007;55(15):6395-6400 DOI: 10.1021/jf070482z.
• 21. Li J., Abdel-Aal E-SM.: Dietary Lutein and Cognitive Function in Adults: A Meta-Analysis of Randomized Controlled Trials. Molecules 2021;26(19):5794. https://doi.org/10.3390/molecules26195794.
• 22. Li, J., Engelberth, A.S.: Quantification and purification of lutein and zeaxanthin recovered from distillers dried grains with solubles (DDGS). Bioresour Bioprocess 2018;5:32. https://doi.org/10.1186/s40643-018-0219-3
• 23. Li, S., Liu, N., Lin, L., Sun, E. D., Li, J. D., & Li, P. K.: Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration. Intl J Ophthal 2018;11(6):970–975. https://doi.org/10.18240/ijo.2018.06.12.
• 24. López-Romero, D.; Izquierdo-Vega, J.A.; Morales-González, J.A.; Madrigal-Bujaidar, E.; Chamorro-Cevallos, G.; Sánchez-Gutiérrez, M.; Betanzos-Cabrera, G.; Alvarez-Gonzalez, I.; Morales-González, Á.; Madrigal-Santillán, E.: Evidence of Some Natural Products with Antigenotoxic Effects. Part 2: Plants, Vegetables, and Natural Resin. Nutrients 2018;10:1954.https://doi.org/10.3390/nu10121954.
• 25. Lopresti AL., Smith S J., Drummond P D.: The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study. Front Nutr 2022;9:843512 DOI=10.3389/fnut.2022.843512 ISSN=2296-861X.
• 26. Madan K & Nanda S.: Hen egg yolk oil: A potential source of bioavailable lutein and zeaxanthin for skin and sun protection. World J Pharm Sci 2017;5(1):71–80.
• 27. Mares J.: Lutein and Zeaxanthin Isomers in Eye Health and Disease. Ann Rev Nutr 2016;36:571-602 doi: 10.1146/annurev-nutr-071715-051110.
• 28. Meskin S.M., Bidlack W.R., Randolph R.K.: Phytochemicals: Aging and Health. CRC Press, 2008.
• 29. Milani, A., Basirnejad, M., Shahbazi, S., & Bolhassani, A.; Carotenoids: biochemistry, pharmacology and treatment. Brit J Pharmacol 2017; 174(11): 1290–1324. https://doi.org/10.1111/bph.13625.
• 30. Min J., Min K.: Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer’s Disease Mortality in Older Adults. Dement Geriat Cogn Disord., 2014;37:246-256. doi: 10.1159/000356486.
• 31. Murillo A.G., Hu S., Fernandez M.L.: Zeaxanthin: Metabolism, Properties, and Antioxidant Protection of Eyes, Heart, Liver, and Skin. Antioxidants. 2019;8(9):390. https://doi.org/10.3390/antiox8090390.
• 32. Nagao M., Sugimura T,, Matsushima T: Environmental Mutagens and Carcinogens. Ann Rev Genet 1978;12(1):117-159.
• 33. Nagtilak S. et al.: Effects of Lutein on HeLa cells. J Adv Med Dental Sci Res 2020;8(12) doi: 10.21276/jamdsr.
• 34. Oma, W., Ahmed A.E., Raslan M., El-Nesr K., Ali M., De Abdelmaksoud M., & El Dahshan D.: Effect of Lutein-Rich Extract on Human Cancer Cells. Middle East J Cancer 2021;12(1):147-150. doi: 10.30476/mejc.2020.82181.1063, https://doi.org/10.1016/j.phrs.2007.01.012.
• 35. Ribaya-Mercado J.D., ScD & Blumberg J.B.: Lutein and Zeaxanthin and Their Potential Roles in Disease Prevention. J Am Col Nutr 2004;23(sup l6):567S-587S, DOI: 10.1080/07315724.2004.10719427.
• 36. Sharma K., Sharma N. K., & Anand A.: Why AMD is a disease of ageing and not of development: mechanisms and insights. Front Aging Neurosci 2014; 6: 151. doi:10.3389/fnagi.2014.00151.
• 37. Tian Y., Kijlstra A., van der Veen R. L., Makridaki M., Murray I. J., & Berendschot T. T.: The effect of lutein supplementation on blood plasma levels of complement factor D, C5a and C3d. PloS one 2013;8(8): e73387.https://doi.org/10.1371/journal.pone.0073387.
• 38. van Herpen-Broekmans, W.M., Klöpping-Ketelaars, I.A., Bots, M. L., Kluft, C., Princen, H., Hendriks, H.F., Tijburg, L.B., van Poppel, G., & Kardinaal, A.F.: Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation. Eur J Epidemiol. 2004;19(10):915-21. doi: 10.1007/s10654-004-5760-z.
• 39. Vasudeva V., Tenkanidiyoor Y.S., Peter A.J., Shetty J., Lakshman S.P., Fernandes R., & Patali K.A.: Radioprotective Efficacy of Lutein in Ameliorating Electron Beam Radiation-induced Oxidative Injury in Swiss Albino Mice. Iran J Med Sci 2018;43(1):41–51.
• 40. von Lintig J.: Provitamin A metabolism and functions in mammalian biology. Am J Clin Nutr 2012;96(5):1234S-44S. doi:10.3945/ajcn.112.034629.
• 41. Wang Y., Zhong Y., Zhang L., Wu Q., Tham Y., Rim T., H, Kithinji D., M, Wu J., Cheng C., Liang H., Yu H., Yang X., Liu L.: Global Incidence, Progression, and Risk Factors of Age-Related Macular Degeneration and Projection of Disease Statistics in 30 Years: A Modeling Study. Gerontol 2022;68:721-735. doi: 10.1159/000518822.
• 42. Wang H., Wang G., Billings R., Li D., Haase S.R., Wheeler P.F., Vance D.E., Li W.: Can Diet Supplements of Macular Pigment of Lutein, Zeaxanthin, and Mesozeaxanthin Affect Cognition? J Alzheimer’s Dis 2022;87(3):1079-1087. DOI: 10.3233/JAD-215736.
• 43. World Cancer Report Cancer research for cancer prevention. Wild C.P., Weiderpass E. and Stewart B.W., eds. International Agency for Research on Cancer, WHO, Lyon 2020.
• 44. Yao Y., Lin JJ., Chee XYJ., Liu MH., Khan SA., Kim JE.: Encapsulation of Lutein via Microfluidic Technology: Evaluation of Stability and In Vitro Bioaccessibility. Foods, 2021;10(11):2646. https://doi.org/10.3390/foods10112646.
• 45. Zafar J., Aqeel A., Shah FI., Ehsan N., Gohar UF., Moga MA., Festila D., Ciurea C., Irimie M., Chicea R.: Biochemical and Immunological implications of Lutein and Zeaxanthin. Int J Mol Sci 2021;22(20):10910. https://doi.org/10.3390/ijms222010910.

Identyfikatory

DOI

10.32394/rpzh.2023.0266