Laminin promotes oligogliogenesis and increases MMPs activity in human neural stem cells of HUCB-NSC line

• Autorzy: Sypecka J. , Dragun-Szymczak P. , Zalewska T. , Domanska-Janik K.
• Języki publikacji: EN

Abstrakty

EN

Oligodendrocytes, the cells responsible for myelin formation and maintenance in CNS, are depleted in many acute and chronic conditions. The stem/progenitor cells stimulation or transplantation might be seriously considered as a long hopedfor therapeutic perspective. Better understanding of the mechanism(s) regulating the activation of the cell lineage from the endogenous progenitor reservoir might be helpful. Therefore an efficient source of donor cells for transplantation in humans is being craved for. In this study we show that the application of extracellular matrix component-laminin promotes oligogliogenesis from neural stem-like cells of human cord blood cells (HUCB-NSC). Although oligodendrocytes constitute a minor subpopulation of spontaneously differentiated HUCB-NSC, the manipulation of active compounds regulating the process of cell commitment results in a several fold increase in their number. Thus cells of the HUCB-NSC line could be considered as a potential source of glial cells, fulfilling the suitable candidate criteria for oligodendrocyte replacement therapy.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 1
• Opis fizyczny: p.37-45,fig.,ref.

Twórcy

autor

Sypecka J.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Dragun-Szymczak P.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Zalewska T.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

autor

Domanska-Janik K.

• NeuroRepair Department, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland

Bibliografia

• Aguirre A, Gallo V (2004) Postnatal neurogenesis and gliogen- esis In the olfactory bulb from NG2-expressing progenitors of the subventricular zone. J Neurosci 24: 10530-10541.
• Archer DR, Cuddon PA, Lipsitz D, Duncan ID (1997) Myelination of the canine central nervous system by glial cell transplantation: a model for repair of human myelin disease. Nat Med 3: 54-59.
• Back SA, Luo NL, Borenstein NS, Levine JM, Volpe JJ, Kinnej HC (2001) Late oligodendrocyte progenitors coin­cide with the developmental window of vulnerability for human perinatal white matter injury. J Neurosci 21: 1302­1312.
• Baker AH, Edwards DR., Murphy G (2002) Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 115: 3719-3727.
• Baron W, Shattil SJ, Ffrench-Constant C (2002) The oligoden­drocyte precursor mitogen PDGF stimulates proliferation by activation of alpha(v)beta3 integrins. EMBO J 21: 1957-1966.
• Bauman N, Pham-Dinh D (2001) Biology of oligodendrocyte and myelin in the mammalian central nervous system. Physiol Rev 81: 871-910.
• Belachew S, Chittajallu R, Aguirre A, Yuan X, Kirby M, Anderson S, Gallo V (2003) Postnatal NG2 proteoglycan- expressing progenitor cells are intrisically multipotent and generate functional neurons. J Cell Biol 161: 169-186.
• Borganzone ER (2002) Induction of oligodendrocyte fate dur­ing the formation of the vertebrate neural tube. Neurochem Res 27: 1361-1369.
• Bovetti S, Bovolin P, Perroteau I, Puche AC (2007) Subventricular zone-derived neuroblast migration to the olfactory bulb is modulated by matrix remodelling. Eur J Neurosci 25: 2021-2033.
• Bużanska L, Machaj EK, B Zabłocka B, Pojda Z, Domańska- Janik K (2002) Human cord blood-derived cells attain neu­ronal and glial features in vitro. J Cell Sci 115: 2131­2138.
• Bużańska L, Jurga M, Stachowiak E, Stachowiak M, Domańska-Janik K (2006) Neural stem-like cell line derived from a nonhematopoietic population of human umbilical cord blood. Stem Cells Dev 15: 391-406.
• Colognato H, Galvin J, Wang Z, Relucio J, Nguyen T, Harrison D, Yurchenco PD, Ffrench-Constant C (2007) Identification of dystroglycan as a second laminin recep­tor in oligodendrocytes, with a role in myelination. Development 134: 1723-1736.
• Colognato H, Ffrench-Constant C, Feltri ML (2005) Human diseases reveal novel roles for neural laminins. Trends Neurosci 28: 480-486.
• Cunningham LA, Wetzel M, Rosenberg GA (2005) Multiple roles for MMPs and TIMPs in cerebral ischemia. Glia 50: 329-339.
• Dewar D, Underhill SM, Goldberg MP (2003) Oligodendrocytes and ischemic brain injury. J Cereb Blood Flow Metab 23: 263-274.
• Dzwonek J, Rylski M, Kaczmarek L (2004) Matrix metal- loproteinases and their endogenous inhibitors in neuronal physiology of the adult brain. FEBS Lett 567: 129-135.
• Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki A, Kuboki T, Takigawa M (2008) Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol Cell Biol 28: 2391-413.
• Fernandez M, Pirondi S, Manservigi M, Giardino L, Calza L (2004) Thyroid hormone participates in the regulation of neural stem cells and oligodendrocyte precursor cells in the central nervous system of adult rat. Europ J Neurosci 20: 2059-2070.
• Finzsch M, Stolt CC, Lommes P, Wegner M (2008) Sox9 and Sox 10 influence survival and migration of oligoden­drocyte precursors in the spinal cord by regulating PDGF receptor alpha expression. Development 135: 637-646.
• Fu SL, Hu JG, Li Y, Wang YX, Jin JQ, Xu XM, Lu PH (2007) A simplified method for generating oligodendro- cyte progenitor cells from neural precursor cells isolated from the E16 rat spinal cord. Acta Neurobiol Exp (Wars) 67: 367-377.
• Garwood J, Garcion E, Dobbertin A, Heck N, Calco V, Ffrench-Constant C, Faissner A (2004) The extracellular matrix glycoprotein Tenascin-C is expressed by oligo- dendrocyte precursor cells and required for the regula­tion of maturation rate, survival and responsiveness to plateled-derived growth factor. Eur J Neurosci 20: 2524-2540.
• Givogri MI, Galbiati F, Fasano S, Amadio S, Perani L, Superchi D, Morana P, Del Carro U, Marchesini S, Brambilla R, Wrabetz L, Bongarzone E (2006) Oligodendroglial progenitor cell therapy limits central neurological deficit in mice with metachromatic leu- kodystrophy. J Neurosci 26: 3109-3119.
• Hodes ME, Pratt VM, Dlouhy SR (1994) Genetics of Pelizaeus- Merzbacher disease. Dev Neurosci 15: 383-394.
• Hoshina N, Tezuka T, Yokoyama K, Kozuka-Hata H, Oyama M, Yamamoto T (2007) Focal adhesion kinase regulates laminin-induced oligodendroglial process outgroth. Genes Cells 12: 1245-1254.
• Höster F, Surtees R, Hoffmann GF (2005) Disorders of inter­mediary metabolism: toxic leucoencephalopathies. J Inherit Metab Dis 28: 345-356.
• Hu JG, Fu SL, Wang YX, Li Y, Jiang XY, Wang XF, Qiu MS, Lu PH, Xu XM (2008) Platelet-derived growth factor factor-AA mediates oligodendrocyte lineage differentia­tion through activation of extracellular signal-regulated kinase signaling pathway. Neuroscience 151: 138-147.
• Kabos P, Ehtesham M, Kabosova A, Black KL, Yu JS (2002) Generation of neural progenitor cells from whole adult bone marrow. Exp Neurol 178: 288-293.
• Koeppen AH, Robitaille Y (2002) Pelizaeus-Marzbacher disease. J Neuropathol Exp Neurol 61: 747-759.
• Kulbatski I, Mothe AJ, Parr AM, Kim H, Kang CE, Bozkurt G, Tator CH (2008) Glial precursor cell transplantation therapy for neurotrauma and multiple sclerosis. Prog Histochem Cytochem 43: 123-176.
• Kwan JA, Schulze CJ, Wang W, Leon H, Sariahmetoglu M, Sung M, Sawicka J, Sims DE, Sawicki G, Schulz R (2004) Matrix metalloproteinase-2 (MMP-2) is present in the nucleus of cardiac myocytes and is capable of cleav­ing poly (ADP-ribose) polymerase (PARP) in vitro. FASEB J 8: 690-692.
• Larsen PH, DaSilva AG, Conant K, Yong VW (2006) Myelin formation during development of the CNS is delayed in matrix metalloproteinase-9 amd -12 null mice. J Neurosci 22: 2207-2214.
• Larsen PH, Wells JE, Stallcup WB, Opdenakker G, Yong VW (2003) Matrix metalloproteinase-9 facilitates remy- elination in part by processing the inhibitory NG2 proteo- glycan. J Neurosci 23: 11127-11135.
• Larsen PH., Yong VW (2004) The expression of matrix met- alloproteinase-12 by oligodendrocytes regulates their maturation and morphological differentiation. J Neurosci 24: 75597-7603.
• Lu L, Chen X, Zhang CW, Yang WL, Wu YJ, Sun L, Bai LM, Gu XS, Ahmed S, Dawe GS, Xiao ZC (2008) Morphological and functional characterization of predif- ferentiation of myelinating glia-like cells from human bone marrow stromal cells through activation of F3/ Notch signaling in mouse retina. Stem Cells 26: 580-90.
• Martino G, Pluchino S (2006) The therapeutic potential of neural stem cells. Nat Neurosci 7: 395-406.
• Milward EA, Fitzsimmons C, Szklarczyk A, Conant K (2007) The matrix metalloproteinases and CNS plasticity: an overview. J Neuroimmunol 187: 9-19.
• Mitra S, Hanson D, Schlaepfer D (2005) Focal adhesion kinase: in command and control of cell motility. Nat Rev Mol Cell Biol 6: 56-68.
• Oh LY, Larsen PH, Yong VW, Krekoski CA, Edwards DR, Donovan F, Werb Z (1999) Gelatinase B/matrix metallo- proteinase-9 is required for oligodendroglial process exten­sion in vivo and in vitro. J. Neurosci 19: 8464-8475.
• Olsen IM, Ffrench-Constant C (2005) Dynamic regulation of integrin activation by intracellular and extracellular signals controls oligodendrocyte morphology. BCM Biol 3: 25-33.
• Pluchino S, Zanotti L, Deleidi M, Martino G (2005) Neural stem cells and their use as therapeutic tool in neurological disorders. Brain Res Rev 48: 211-219.
• Reier PJ (2004) Cellular transplantation strategies for spinal cord injury and transplantation neurobiology. NeuroRx 1: 424-451.
• Rosenberg GA (2002) Matrix metalloproteinases and neu­roinflammation in multiple sclerosis. Neuroscientist 8: 586-595.
• Schoonover CM, Seibel M, Jolson DM, Stack MJ, Rahman RJ, Joanes SA, Mariash CN Anderson GW (2004) Thyroid hormone regulates oligodendrocyte accumula­tion in developing rat brain white matter tracts. Endocrinology 145: 5013-5020.
• Seeds N, Siconolfi L, Haffke S (1997) Neuronal extracellu­lar proteases facilitate cell migration, axonal growth and pathfinding. Cell Tissue Res 290: 367-370.
• Seitelberger F (1995) Neuropathology and genetic of Pelizaeus-Merzbacher disease. Brain Pathol 5: 267-273.
• Sherman DL, Brophy PJ (2005) Mechanisms of axon ensheathment and myelin groth. Nat Rev Nuerosci 6: 683-690.
• Si-Tayeb K, Monvoisin A, Mazzocco C, Lepreux S, Decossas M, Cubel G, Taras D, Blanc JF, Robinson DR, Rosenbaum J (2006) Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. Am J Pathol 69: 1390-1401.
• Sternlicht MD, Werb Z (2001) How matrix metalloprotei­nases regulate cell behavior. Annu Rev Cell Dev Biol 17: 463-516.
• Suzuki T, Mandai M, Akimoto M, Yoshimura N, Takahashi M (2006) The simultaneous treatment of MMP-2 stimu­lants in retinal transplantation enhances grafted cell migration into the host retina. Stem Cells 24: 2406­2411.
• Sypecka J, Sarnowska A, Domanska-Janik K (2009) The crucial role of the local microenvironment in fate decision of neonatal rat NG2 progenitors. Cell Prolif (in press).
• Uhm JH, Dooley NP, Oh LY, Yong VW (1998) Oligodendrocytes utilize a matrix mettaloproteinase, MMP-9, to extend processes along an astrocyte extracel­lular matrix. Glia 22: 53-63.
• Vendrame M, Gemma C, Mesquita D, Collier L, Bickford PC, Sanberg CD, Sanberg PR, Pennypacker KR, Willing AE (2005) Anti-inflammatory effects of human cord blood cells in a rat model of a stroke. Stem Cell Dev 14: 595-604.
• Visse R, Nagase H (2003) Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, func­tion, and biochemistry. Circ Res 92: 827-839.
• Volpe JJ (2003) Cerebral white matter injury of the prema­ture infant-more common than you think. Pediatrics 1: 176-180.
• Watkins TA, Barres BA (2002) Integrins as developmental switches. Nature Cell Biol 4: 253-255.
• Watanabe M, Toyama Y, Nishiyama A (2002) Differentiation of proliferated NG2-positive glial progenitor cells in a remyelinating lesion. J Neurosci Res 69: 826-836.
• Windrem MS, Nunes MC, Rashbaum WK, Schwartz TH, Goodmann RA, McKhannG, Goldman SA (2004) Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenittaly dysmyelinated brain. Nat Med 10: 93-97.
• Yong VW, Power C, Forsyth P, Edwards DR (2001) Metalloproteinases in biology and pathology of the ner­vous system. Nat Rev Neurosci 2: 502-511.
• Zhang Y, Denham J, Thies R (2006) Oligodendrocyte progeni­tor cells derived from human embryonic stem cells express neurptrophic factors. Stem Cells Dev 15: 943-952.
• Zhao WQ, Li H, Yamashita K, Guo XK, Hoshino T, Yoshida S, Shinya T, Hayakawa T (1998) Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts. J Cell Sci 111: 1147-1153.

Uwagi

PL

Rekord w opracowaniu