Role of MMP-9 in schizophrenia-like behaviors in rodents

• Autorzy: Vafadari B. , Kaczmarek L.
• Języki publikacji: EN

Abstrakty

EN

INTRODUCTION: Schizophrenia is recognized by 3 symptoms, classified as positive, negative and cognitive. Positive symptoms may be modelled in experimental animal models by hyperlocomotion, whereas in negative symptoms lack of interest in rewards and problems in social behavior can be demonstrated. Finally, poor working memory may correlate with cognitive symptoms of schizophrenia. AIM(S): We employed mouse models of schizophrenia for positive, cognitive and negative symptoms to investigate the role of diminished MMP-9 and stress in pathogenesis of schizophrenia in these animals. METHOD(S): Mice with genetically lowered MMP-9 levels in heterozygotes (+/−, MMP‑9 HET) were employed, along their wild type (WT, +/+) littermates. Since early-life stress is regarded as a factor promoting schizophrenia, we subjected the mice, in some experiments, to daily (for 21 days) encounter with an aggressive conspecific and then behavioral phenotyping were done. RESULTS: Alterations in the level of active MMP-9 in the brain result in increased sensitivity to locomotor hyperactivity induced by MK-801. On the other hand chronic stress, potentiates negative symptoms of schizophrenia in MMP-9 Het mice such as depressive behaviors and social behaviors impairment. Cognitive symptoms such as poor working memory can be seen in MMP-9 HET control mice. CONCLUSIONS: These results support the notion that MMP-9 alterations in brain may play a role in schizophrenia. FINANCIAL SUPPORT: Extrabrain EU FP7.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: Suppl.1
• Opis fizyczny: p.60

Twórcy

autor

Vafadari B.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland

autor

Kaczmarek L.

• Department of Molecular and Cellular Neurobiology, Nencki Institute of Experimental Biology Polish Academy of Sciences, Warsaw, Poland