Wound healing potential of Capparis spinosa against cutaneous wounds infected by Escherichia coli in a rat model

• Autorzy: Asheghian Amiri I. , Moslemi H.R. , Tehrani-Sharif M. , Kafshdouzan K.

Warianty tytułu

PL

Możliwość leczenia ran ciętych zainfekowanych Escherichia coli za pomocą Capparis spinosa na modelu szczurzym

• Języki publikacji: EN

Abstrakty

EN

Wound infection has become a major medical problem in recent years. This study was conducted to evaluate the healing activity of Capparis spinosa against surgical wounds infected by Escherichia coli. Twenty male rats were divided into two groups. Excisions were created surgically on the animals’ skin and then infected with E coli. Group 1 was treated with C spinosa while Group 2 was untreated. Wound biopsy specimens were collected on days 5, 10 and 16 and analyzed. Results showed that the hydroxyproline content in treatment group was significantly higher in various post wounding days. Protein content increased gradually in ten days. Results of histopathological studies showed moderate to intense granulation tissue formation in treated group on day 10. The histopathological studies showed, that the new epidermis in treated group was thicker than in control group on day 16 post wounding. The present study has demonstrated that ethanol extract of C spinosa includes properties that accelerate wound healing activities.

PL

Infekcje ran stały się ostatnio dużym problemem medycznym. W prezentowanym artykule przedstawiono badania przeprowadzone w celu określenia działania Capparis spinosa przeciwko infekcjom ran pooperacyjnych przez Escherichia coli. Dwadzieścia szczurów płci męskiej podzielono na dwie grupy. Skórę zwierząt nacięto operacyjnie, a następnie ranę zainfekowano E coli. Grupę 1 leczono C spinosa, grupa 2 nie była leczona. Biopsję ran przeprowadzono 5., 10. i 16. dnia, a następnie poddano analizie. Wyniki wykazały, że zawartość hydroksyproliny w grupie leczonej była wyraźnie wyższa w poszczególnych dniach następujących po powstaniu rany. Zawartość białka rosła stopniowo przez 10 dni. Obserwacje histopatologiczne wskazywały na umiarkowaną do intensywnej granulację tkanki w grupie leczonej 10. dnia. Na ich podstawie stwierdzono również, że nowa epiderma w grupie leczonej była grubsza niż w grupie kontrolnej po 16 dniach od zranienia. Prezentowane badania wskazują, że wyciąg etanolowy z C spinosa ma właściwości przyspieszające gojenie się ran.

Słowa kluczowe

EN

wound; cutaneous wound; Escherichia coli; wound infection; treatment; Capparis spinosa; plant extract; ethanol extract; rat; animal model

• Wydawca: -
• Czasopismo: Herba Polonica
• Rocznik: 2015
• Tom: 61
• Numer: 2
• Opis fizyczny: p.63-72,fig.,ref.

Twórcy

autor

Asheghian Amiri I.

• Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran

autor

Moslemi H.R.

• Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran

autor

Tehrani-Sharif M.

• Department of Clinical Sciences, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran

autor

Kafshdouzan K.

• Department of Microbiology, Faculty of Veterinary, Medicine Semnan University, Semnan, Iran

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Identyfikatory

DOI

10.1515/hepo-2015-0016