Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2009 | 59 | 3 |
Tytuł artykułu

Tocopherol acetate vs. oxidative stress induced by physical exercise in rats

Treść / Zawartość
Warianty tytułu
Języki publikacji
The study was aimed at determining the effect of various doses of tocopherol acetate on the oxidative stress induced by physical exercise in rats. The experiment was conducted on growing Wistar male rats. The oxidative stress was induced by running on a treadmill with tape movement velocity of 20 m/min for 15 min for the period of 10 days. After that period, samples of rats serum were determined for levels of α-tocopherol and lipid peroxides as well as for antioxidative potential and α-tocopherol content of liver. The study demonstrated that physical exercise was leading to enhanced release of tocopherol from liver to blood, depending on the applied dose of the vitamin. The serum level of lipid peroxides was lower in the animals subjected to the training and inversely proportional to the dose of tocopherol. In the animals not subjected to exercise, the oxidative stress was observed to be enhanced at the highest dose of the vitamin.
Słowa kluczowe
Opis fizyczny
  • Department of Human Nutrition, Warsaw University of Life Sciences, ul. Nowoursynowska 159c, 02-776 Warsaw, Poland
  • Department of Human Nutrition, Warsaw University of Life Sciences, ul. Nowoursynowska 159c, 02-776 Warsaw, Poland
  • Department of Human Nutrition, Warsaw University of Life Sciences, ul. Nowoursynowska 159c, 02-776 Warsaw, Poland
  • 1. Antosiewicz J., Matuszkiewicz A., Olek R.A., Kaczor J.J., Ziółkowski W., Wakabayashi T., Popinigis J., Content and redistribution of vitamin E in tissues of Wistar rats under oxidative stress induced by hydrazine. Arch. Environ. Contam. Toxicol., 2002, 42, 363–368.
  • 2. Aquilo A., Tauler P., Fuentespina E., Tur J.A., Cordova A, Pons A., Antioxidant response to oxidative stress induced by exhaustive exercise. Physiol. Behavior, 2005, 84, 1–7.
  • 3. Avellini L., Chiaradia E., Gaiti A., Effect of exercise training, selenium and vitamin E on some free radical scavengers in horses. Comp. Biochem. Phys., B, 1999, 123, 147–154.
  • 4. Azzi A., Molecular mechanism of α-tocopherol action. Free Rad. Biol. Med., 2007, 43, 16–21.
  • 5. Bansal A.K., Balsan M., Soni G., Bhatnagar D., Protective role of vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rats liver. Chemico-Biol. Interactions, 2005, 156, 101–111.
  • 6. Bartosz G., Druga twarz tlenu. Wolne rodniki w przyrodzie. 2006, PWN, Warszawa (in Polish).
  • 7. Bjelakovic G., Nikolowa D., Gluud L.L., Simonetti R.G., Gluud C., Mortality in randomized trials of antioxidants supplements for primary and secondary prevention: systematic review and meta-analysis. JAMA, 2007, 297, 8, 842–857
  • 8. Clycombe K.J., Meydani S.N., Vitamin E and genome stability. Mut. Res., 2001, 475, 37–44.
  • 9. Deaton Ch.M., Marlin D., Exercise-associated oxidative stress. Clin. Techn. Equine Practice, 2003, 2, 278–291.
  • 10. Faff J., Does physical effort require increased antioxidants intake. Żyw. Człow. Met., 2003, 30, 290–296 (in Polish).
  • 11. Hathcock J.M., Azzi A., Blumberg J., Bray T., Dickinson A., Frei B., Jialal I., Johnston C.S., Kelly F.J., Kraemer K., Packer L., Parthasarathy S., Sies H., Traber M.G., Vitamin E and C are safe across a broad range of intakes. Am. J.Clin. Nutr., 2005, 81, 736–745.
  • 12. Hill K.E., Montine T.J., Montley A.K., Li X., May J., Burk R.F., Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Am. J. Clin. Nutr., 2003, 77, 1484–1488.
  • 13. Hill K.E., Montley A.K., Li X., May J., Burk R.F., Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs. J. Nutr., 2001, 131, 1798–1802.
  • 14. Jentzch A.M., Bachmann H., Furst P., Biesalski H.K., Improved analysis of malondialdehyde in human body fluids. Free Rad. Biol. Med., 1996, 20, 251–256.
  • 15. Jordão Jr. A.A., Garcia C.P., Arantes M.R., Meirelles M.S., Vannucchi H., Effect of acute dose of ethanol on lipid peroxidation in rats: action of vitamin E. Food Chem. Toxicol., 2004, 42, 459–464.
  • 16. Mastaloudis A., Yu T.W., O’Donnell R.P., Frei B., Dashwood R.H., Traber M.G., Endurance exercise results in DNA damage as detected by the comet assay. Free Rad. Biol. Med., 2004, 26, 966–975.
  • 17. McAnulty S.R., McAnulty L.S., Nieman D.C., Morrow J.D., Shooter L.A., Holmes S., Heward C., Henson D.A., Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise. J. Nutr. Biochem., 2005, 16, 530–537.
  • 18. Radak Z., Chung H.Y., Goto S., Systematic adaptation to oxidative challenge induced by regular exercise. Free Rad. Biol. Med., 2008, 44, 153–159.
  • 19. Ramel A., Wagner K-H, Elmadfa I., Plasma antioxidants and lipid oxidation after submaximal resistance exercise in men. Eur. J. Nutr., 2004, 43, 2–6.
  • 20. Re R., Pellegrini N., Proteggente A., Pannola A., Yang M., Rice-Evans C., Antioxidant activity applying an improved ABTS radical cation decolorization assay. Free Rad. Biol. Med., 1999, 26, 1231–1237.
  • 21. Reeves P.G., Components of the AIN-93 diets as improvements in the AIN-76A diet. J. Nutr., 1997, 127, 838S-841S.
  • 22. Sacheck J.M., Decker E.A., Clarcson P.M., The effect of diet on vitamin E intake and oxidative stress in response to acute exercise in female athletes. Eur. J. Appl. Phys., 2000, 83, 40–46.
  • 23. Schneider C., Chemistry and biology of vitamin E. Mol. Nutr. Food Res., 2005, 44, 7–30
  • 24. Schneider M., Niess A.M., Rozario F., Angres C., Tschositsch K., Battenfeld N., Schäffer M., Northoff H., Dickhuth H.H., Fehrenbach E., Trommer W.E., Biesalski H.K., Vitamin E supplementation does not increase the vitamin C radical concentration at rest and after exhaustive exercise in healthy male subjects. Eur. J. Nutr., 2003, 42, 195–200.
  • 25. Somani S.M., Frank S., Rybak L.P., Response of antioxidant system to acute and trained exercise in rat heart subcellular fractions. Pharm. Biochem. Behav., 1995, 51, 627–634.
  • 26. Sroka Z., Gamian A., Lisowski W., Low-molecular antioxidant compounds of natural origin. Post. Hig. Med. Dośw., 2005, 59, 34–41 (in Polish).
  • 27. Stahl W., van den Berg H., Arthur J., Bast A., Dainty J., Faulks R.M., Gärtner C., Haenen G., Hollman P., Holst B., Kelly F.J., Polidori M.C., Rice-Evans C., Southon S., van Vliet T., Viña-Ribes J., Williamson G., Astley S.B., Vitamin E bioavailability and metabolism. Mol. Asp. Med., 2002, 23, 39–100.
  • 28. Traber M.G., Atkinson J., Vitamin E, antioxidant and nothing more. Free Rad. Biol. Med., 2007, 43, 4–15.
  • 29. Van Vliet T., Determination of several retinoids, carrotenoids and E vitamins by high-performance liquid chromatography. J. Chromatogr. A, 1991, 533, 179–186.
  • 30. Zinng J.M., Vitamin E: an overview of major research directions. Mol. Asp. Med., 2007, 28, 400–422.
rekord w opracowaniu
Typ dokumentu
Identyfikator YADDA
JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.