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2012 | 56 | 3 |

Tytuł artykułu

Implications of blood coagulation and fibrynolytic disorders in serve endometritis-pyometra complex in bitches

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Twenty bitches with acute endometritis-pyometra complex (EPC) and 20 clinically healthy bitches were examined. The following coagulation parameters were determined in haemostatic evaluations: prothrombin time (PT), activated partial thromboplastin time (aPTT), thrombin time (TT), fibrinogen concentrations (FBG), D-dimer concentrations (D-D), antithrombin activity (AT), and blood platelet counts (PLT). Morphological and biochemical blood parameters were also analysed. Examinations of animals affected by EPC revealed blood coagulation and fibrinolytic disorders, and the noted results (PT 13.7 ±1.06 s, aPTT 23.4 ±1.04 s, TT 15.6 ±0.68 s, FBG 2.2 g/L, D-D 785.4 ±103.05 µg/L, AT 111.1 ±13.51%, PLT 169.30 ±126.31 10³/µL) point to a high risk of disseminated intravascular coagulation. The findings indicate that the coagulation parameters of bitches affected by EPC should be analysed before treatment as the noted disorder can significantly complicate therapy and ovariohysterectomy, and endanger the patients' life.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

56

Numer

3

Opis fizyczny

p.293-297,ref.

Twórcy

autor
  • Department of Internal Diseases with Clinic, Faculty of Veterinary Medicine, University of Warmia and Mazury, 10-957 Olsztyn, Poland
autor

Bibliografia

  • 1. Boryczko Z., Katkiewicz M., Bostedt H., Gajewski Z.: Aetiopathogenesis, symptoms, diagnosis and therapy of pyometra in a bitch. Medycyna Wet 2001, 57, 246-250.
  • 2. Dindo D., Breitenstein S., Hahnloser D., Seifert B., Yakarisik S., Asmis L.M., Muller M.K., Clavien P.A.: Kinetics of D-dimer after general surgery. Blood Coagul Fibrinolysis 2009, 20, 347-352.
  • 3. Domosławska A., Janowski T., Jurczak A.: Course of uterine involution and the level of progesterone in bitches with endometritis-pyometra complex treated with aglepristone. Bull Vet Inst Pulawy 2010, 54, 19-23.
  • 4. Fransson B.A., Lagerstedt A.S., Bergstrom A., Hagman R., Park J.S., Chew B.P., Evans M.A., Ragle C.A.: C- reactive protein, tumor necrosis factor α, and interleukin- 6 in dogs with pyometra and SIRS. J Vet Emerg Crit Car 2007, 17, 373-381.
  • 5. Gentry P.A.: Comparative aspects of blood coagulation. Vet J 2004, 168, 238-251.
  • 6. Hagman R., Kindahl H., Lagerstedt A.S.: Pyometra in bitches induces elevated plasma endotoxin and prostaglandin F₂α metabolite levels. Acta Vet Scand 2006, 47, 55-68.
  • 7. Hagman R., Kühn I.: Escherichia coli strains isolated from the uterus and urinary bladder of bitches suffering from pyometra: comparison by restriction enzyme digestion and pulsed-field gel electrophoresis. Vet Microbiol 2002, 84, 143-153.
  • 8. Horkheimer I., Schuster D.P.: The role of platelet- activating factor in sepsis: a bench-to-bedside review. Advances In Sepsis 2002, 2, 2-7.
  • 9. Janicki K.: Haematology, published by Wydawnictwo Lekarskie PZWL, Warsaw, 2001, pp. 394-429.
  • 10. Mischke R., Nolte I.: Laboratory diagnosis and differential diagnosis of disseminated intravascular coagulation in the dog. Berl Munch Tierarztl 1992, 105, 401-410.
  • 11. Plavec T., Celinsek B., Dolinar K., Pecar J., Nemec A., Butinar J.: Haemostasis impairment in bitches with pyometra. Acta Vet (Beograd) 2006, 56, 529-540.
  • 12. Poll T., Levi M., Hack E.C., Cate H., Deventer S.J.H., Eerenberg A.J.M., Groot E.R.. Jansen J., Gallati H., Buller H.R., Cate J.W., Aarden L.A.: Elimination of interleukin 6 attenuates coagulation activation in experimental endotoxemia in chimpanzees. J Exp Med 1994, 179, 1253-1259.
  • 13. Pretzer S.D.: Clinical presentation of canine pyometra and mucometra: A review. Theriogenology 2008, 70, 359-363.
  • 14. Radwińska J.: Effect of the BVD-MD virus on coagulation and fibrinolytic systems in dairy cows. Bull Vet Inst Pulawy 2010, 54, 293-298.
  • 15. Sawicka B.: Disseminated intravascular coagulation: clinical, laboratory and therapeutic aspects. Postępy Nauk Med 2000, 3, 40-50.
  • 16. Sobiech P., Targoński R., Stopyra A., Żarczyńska K.: Changes in the blood coagulation profile after ovariohysterectomy in female dogs. Pol J Vet Sci 2011, 14, 289-290.
  • 17. Stokol T., Brooks M.B., Erb H.N., Mauldin G.E.: D- dimer concentrations in healthy dogs and dogs with disseminated intravascular coagulation. Am J Vet Res 2000, 61, 393-398.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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