Anodal transcranial direct current stimulation with monopolar pulses improves limb use after stroke by enhancing inter‑hemispheric coherence

• Autorzy: Schjetnan A.G.P. , Gidyk D.C. , Metz G.A.S. , Luczak A.
• Języki publikacji: EN

Abstrakty

EN

Post‑stroke neurological deficits, such as sensorimotor impairments, are often permanent and a leading cause of disability. Stroke is also associated with changes in neuronal synchrony among different brain areas. Multiple studies demonstrated that non‑invasive brain stimulation, such as transcranial direct current stimulation (tDCS), enhances the efficacy of existing rehabilitative therapies. We hypothesized that the therapeutic effects of tDCS could be due to its influence on neuronal synchrony. To study this, we recorded local field potentials in rats treated with anodal tDCS (a‑tDCS) after unilateral ischemic motor cortex lesion. To enhance the effect of a‑tDCS on neuronal synchrony, we added monopolar pulses (a‑tDCSmp) during a treatment. We found that ischemic lesions reduced interhemispheric coherence in the low gamma frequency range. By contrast, a‑tDCSmp treatment increased interhemispheric coherence along with motor improvement in a skilled reaching task. These observations indicate that increased neuronal coherence is a likely mechanism by which tDCS improves stroke recovery. Moreover, this work adds to previous evidence that measures of brain coherence could be used as a biomarker of stroke recovery, which may help in the design of more effective tDCS protocols for stroke rehabilitation.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2019
• Tom: 79
• Numer: 3
• Opis fizyczny: p.290-301,fig.,ref.

Twórcy

autor

Schjetnan A.G.P.

• Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada
• Krembil Research Institute, Toronto Western Hospital, Toronto, Canada

autor

Gidyk D.C.

• Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada

autor

Metz G.A.S.

• Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada

autor

Luczak A.

• Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, Canada

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Identyfikatory

DOI

10.21307/ane‑2019‑027