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2014 | 58 | 4 |

Tytuł artykułu

Amphenicols stability in medicated feed – development and validation of liquid chromatography method

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
A liquid chromatography-ultraviolet detection method for the determination of florfenicol (FF) and thiamphenicol (TAP) in feeds is presented. The method comprises the extraction of analytes from the matrix with a mixture of methanol and acetonitrile, drying of the extract, and its dissolution in phosphate buffer. The analysis was performed with a gradient programme of the mobile phase composed of acetonitrile and buffer (pH = 7.3) on a Zorbax Eclipse Plus C18 (150 × 4.6 mm, 5 µm) analytical column with UV (λ = 220 nm) detection. The analytical procedure has been successfully adopted and validated for quantitative determination of florfenicol and thiamphenicol in feed samples. Sensitivity, specificity, linearity, repeatability, and intralaboratory reproducibility were included in the validation. The mean recoven of amphenicols was 93.5% within the working range of 50-4000 mg/kg. Simultaneous determination of chloramphenicol, which is banned in the feed, was also included within the same procedure of FF and TAP stability studies. Storing the medicated feed at room temperature for up to one month decreased concentration in the investigated drugs even by 45%. These findings are relevant to successful provision of therapy to animals.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

58

Numer

4

Opis fizyczny

p.621-629,fig.,ref.

Twórcy

autor
  • Department of Radiobiology, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Veterinary Pharmacy, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Veterinary Pharmacy, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Pharmacology and Toxicology, National Veterinary Research Institute, 24-100 Pulawy, Poland
autor
  • Department of Veterinary Pharmacy, National Veterinary Research Institute, 24-100 Pulawy, Poland

Bibliografia

  • 1. Andrée S., Jira W., Schwind K.H., Wagner H., Schwägele F.: Chemical safety of meat and meat products. Meat Sci 2010, 86, 38-48.
  • 2. Bilaridžić N., Varenina I., Solomun Kolanović B.: Control of chloramphenicol in samples of meat, meat products and fish. Meso 2011, 13, 192-196.
  • 3. Boscher A., Guignard C., Pellet T., Hoffmann L., Bohn T.: Development of a multi-class method for the quantification of veterinary drug residues in feeds by liquid chromatography- tandem mass spectrometry. J Chromatogr A 2010, 1217, 6394-6404.
  • 4. Commission Decision 2001/1322/EC of 29 June 2001 Amending Annexes I and III to Council Regulation (EEC) No. 2377/90 laying down a community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin. OJL177/52, 30.6.2001.
  • 5. Commission Decision 2002/657/EC implementing Council Directive 96/23/EC concerning the performance of analytical methods and the interpretation of results. OJ L. 221, 17.8.2002, pp. 16-17.
  • 6. Commission Decision 2003/181/EC of 13 March 2003 on amending Decision 2002/657/EC as regards—of minimum required performance limits (MRPLs) for certain residues in food of animal origin. OJ L71 15.03.2003 pp. 17-18.
  • 7. Commission Regulation (EC) No. 1805/2006 of 7 December 2006 Amending Annex I to Council Regulation (EEC) No 2377/90 laving down a community procedure for the establishment of maximum residue limits of veterinary medicinal products in foodstuffs of animal origin, as regards thiamphenicol, fenvalerate and meloxicam. OJ L 343 8.12.2006 pp. 66-68.
  • 8. Council Directive 90/167/EEC laying down the conditions governing the preparation, placing on the market and use of medicated feeds in the Community. OJ L 92, 07.04.1990, pp. 42-48.
  • 9. Dang P.K., Degand G., Douny C., Ton V.D., Maghuin-Rogister G., Scippo M.L.: Optimisation of a new two-plate screening method for the detection of antibiotic residues in meat. Int J Food Sci Tech 2011, 46, 2070-2076, doi:10.111 l/j.1365- 2621.2011,02718.x
  • 10. Falagas M.E., Grammatikos A.P., Michalopoulos A.: Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Therapy 2008, 6, 593-600. doi: 10.1586/14787210.6.5.593. PMID 18847400.
  • 11. Franje C.A., Changb S.K., Shyua C.L., Davisc J.L., Leea Y.W.: Differential heat stability of amphenicols characterized by structural degradation, mass spectrometry and antimicrobial activity. J Pharmaceut Biomed 2010, 53, 869-877.
  • 12. Fuchs F.D.: "Tetraciclinas e cloranfenicol". In: Farmacologia clínica: fundamentos da terapêutica racional. Edited by Fuchs F.D., Wannmacher L., Ferreira M.B., Guanabara Koogan, Rio de Janeiro, 2004. p. 375.
  • 13. Hayes J.M.: Determination of florfenieol in fish feed by liquid chromatography. J AOAC Int 2005, 88, 1777-1783.
  • 14. Hayes J.M., Gilewicz R., Freehauf K., Fetter M.: Assay of florfenieol in swine feed: interlaboratory study. J AOAC Int 2009, 92, 340-347.
  • 15. Huet A.C., Fodey T., Haughey S.A., Weigel S., Elliott C., Delahaut P.: Advances in biosensor-based analysis for antimicrobial residues in foods. Trend Anal Chem 2010, 29, 1281-1294.
  • 16. Luo P.J., Cao X.Y., Wang Z.H., Jiang H.Y., Zhang S.X., Chen X., Wang J.P., Feng C.M., Shen J.Z.: Development of an enzyme-linked immunosorbent assay for the detection of florfenicol in fish feed. Food Agr Immunol 2009, 20, 57-65.
  • 17. Luo P.J., Jiang W.X., Chen X., Shen J.Z., Wu Y.N.: Technical note: development of an enzyme-linked immunosorbent assay for the determination of florfenieol and thiamphenicol in swine feed. J Anim Sci 2011, 89, 3612-3616.
  • 18. Patyra E., Kowalczyk E., Kwiatek K.: Determination of chlorotetracycline and doxycycline in medicated teedingstuffs by liquid chromatography. Bull Vet Inst Pulawy, 2012, 56, 329-333.
  • 19. Pietroń W.J., Cybulski W., Krasucka D., Mitura A., Kos K., Antczak M.: Determination of five sulphonamides in medicated feedingstuffs by liquid chromatograph with ultraviolet detection. Bull Vet Inst Pulawy, 2013, 57, 545-552
  • 20. Pouliquen H., Morvan M.L.: Determination of florfenieol in freshwater, sediments and bryophyte fontinalis antipyretica by HPLC with fluorescence detection. Chromatographia 2005, 62, 225-231.
  • 21. Regulation (EC) No 882/2004 of the European Parliament and of the Council of 29 April 2004. On official controls performed to ensure the verification of compliance with feed and food law animal health and animal welfare rules.
  • 22. Rich M., Ritterhoff R., Hoffmann R.: A fatal case of aplastic anemia following chloramphenicol (chloromycetin) therapy. Ann Int Med 1950, 33, 1459-1467.
  • 23. Riviere J.E., Papich M.G. Veterinary Pharmacology and Therapeutics. Wiley-BlackWell, Hong Kong 2009.
  • 24. Shen J.Z., Xia X., Jiang H., Li C., Li J., Li X., Ding S.: Determination of chloramphenicol, thiamphenicol, florfenieol, and florfenicol amine in poultry and porcine muscle and liver by gas chromatography-negative chemical ionization mass spectrometry. J Chromatogr B 2009, 877, 1523-1529.
  • 25. Shinoda N., Kojima F., Sugiura K.J.: Residuals. Simultaneous determination of residues of chloramphenicol and florfenieol in animal feed by liquid chromatography tandem mass spectrometry. J Residuals Sci Tech 2011, 8, 125-129.
  • 26. Syriopoulou V.P., Harding A.L., Goldmann D.A., Smith A.L.: In vitro antibacterial activity of fluorinated analogs of chloramphenicol and thiamphenicol. Antimicrob Agents Chemother 1981, 19, 294-297.
  • 27. Sniegocki T., Posyniak A., Gbylik-Sikorska A., Zmudzki J.: Determination of chloramphenicol in milk using a QuEChERS-based on liquid chromatography tandem mass spectrometry method. Anal Lett 2014, 47, 568-578.
  • 28. The Annual Report of The Rapid Alert System for Food and Feed (Rapid Alert System for Food and Feed, RASFF, 2007. doi:10.2772/63727
  • 29. The Annual Report of The Rapid Alert System for Food and Feed (Rapid Alert System for Food and Feed, RASFF, 2013. doi: 10.2772/33031.
  • 30. Vega M.H., Jara E.T., Aranda M.B.: Monitoring the dose of florfenieol in medicated salmon feed by planar chromatography (HPTLC) Jap J Planar Chromat 2006, 19, 204-207.
  • 31. Vue C., Schmidt L. J., Stehly G.R., Gingerich W.H.: Liquid chromatographic determination of florefnicol in the plasma of multiple species offish. J Chromatogr B 780, 2002, 111-117.
  • 32. Wen L.L., Ren J.L., Maw R.L.: Supercritical fluid extraction in situ derivatization for simultaneous determination of chloramphenicol, florfenicol and thiamphenicol in shrimp. Food Chem 2010, 121, 797-802.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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