Vasostatin increases oxygenation of B16-F10 melanoma tumors and raises therapeutic efficacy of cyclophosphamide

• Autorzy: Cichon T. , Jarosz M. , Smolarczyk R. , Ogorek B. , Matuszczak S. , Wagner M. , Mitrus I. , Sochanik A. , Jazowiecka-Rakus J. , Szala S.
• Języki publikacji: EN

Abstrakty

EN

One of the preconditions of effective anticancer therapy is efficient transfer of the therapeutic agent (chemotherapeutic) to tumor cells. Fundamental barriers making drug delivery and action difficult include underoxygenation, elevated interstitial pressure, poor and abnormal tumor blood vascular network and acidic tumor milieu. In this study we aimed at developing an optimized scheme of administering a combination of an angiogenesis-inhibiting drug (vasostatin) and a chemotherapeutic (cyclophosphamide) in the therapeutic treatment of mice bearing experimental B16-F10 melanoma tumors. We report that the strongest tumor growth inhibition was observed in mice that received two, three or four vasostatin doses in combination with one injection of cyclophosphamide (i.e., V2 + CTX, V3 + CTX or V4 + CTX schemes). Double administration of vasostatin increases oxygenation of B16-F10 tumors. On the other hand, its five-fold administration lowers tumor oxygenation, breaks down tumor vascular network (increasing hypoxia) and leads in consequence to death of cancer cells and appearance of necrotic areas in the tumor. A decreased cyclophosphamide dose in combination with two doses of vasostatin (V2 + CTX scheme) inhibits tumor growth similarly to a larger dose of cyclophosphamide alone.

Słowa kluczowe

EN

vasostatin; increase oxygenation; melanoma tumour; therapeutic efficacy; cyclophosphamide; oxygenation; tumour blood vessel normalization; anticancer therapy; vascular endothelial growth factor; cell culture medium

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2012
• Tom: 59
• Numer: 3
• Opis fizyczny: p.377-381,fig.,ref.

Twórcy

autor

Cichon T.

autor

Jarosz M.

autor

Smolarczyk R.

• Center for Translational Research and Molecular Biology of Cancer, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch, Gliwice, Poland

autor

Ogorek B.

autor

Matuszczak S.

autor

Wagner M.

autor

Mitrus I.

autor

Sochanik A.

autor

Jazowiecka-Rakus J.

autor

Szala S.

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