Unique fingerprint of intergeniculate leaflet neurons among lateral geniculate body-the variability of low-threshold currents

• Autorzy: Chrobok L. , Palus K. , Lewandowski M. H.
• Języki publikacji: EN

Abstrakty

EN

The intergeniculate leaflet (IGL) is a small but important structure of the mammalian biological clock located in the thalamus. It has been previously classified as an integral part of lateral geniculate nucleus (LGN) but there are many histochemical and functional differences. In this study we have characterized the diversity of low-threshold ionic currents what helped us to distinguish different IGL neuronal subpopulations. The in vitro patch clamp recordings in voltage and current clamp mode were performed on the brain slices from Wistar rats. After each experiment, the immunohistochemical study was carried out to verify the location and the biochemical nature of the recorded cell. Our results show a group of IGL neurons expressing inward calcium currents, similar to the ones recorded from LGN interneurons, but characterized by much lower amplitude. Moreover, some IGL neurons show low-threshold outward currents what is unique feature among LGN cells.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2014
• Tom: 74
• Numer: 3
• Opis fizyczny: p.331

Twórcy

autor

Chrobok L.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Palus K.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland

autor

Lewandowski M. H.

• Department of Neurophysiology and Chronobiology, Jagiellonian University, Krakow, Poland