Efficacy of topical therapy with newly developed terbinafine and econazole formulations in the treatment of dermatophytosis in cats

• Autorzy: Iwaskiene M. , Matusevicius A.P. , Grigonis A. , Zamokas G. , Babickaite L.
• Języki publikacji: EN

Abstrakty

EN

In the field of veterinary dermatology dermatophytosis is one of the most frequently occurring infectious diseases, therefore its treatment should be effective, convenient, safe and inexpensive. The aim of this study was to evaluate the efficacy of newly developed topical formulations in the treatment of cats with dermatophytosis. Evaluation of clinical efficacy and safety of terbinafine and econazole formulations administered topically twice a day was performed in 40 cats. Cats, suffering from the most widely spread Microsporum canis-induced dermatophytosis and treated with terbinafine hydrochloride 1% cream, recovered within 20.3±0.88 days; whereas when treated with econazole nitrate 1% cream, they recovered within 28.4±1.14 days. A positive therapeutic effect was yielded by combined treatment with local application of creams and whole coat spray with enilconazole 0.2% emulsion „Imaverol”. Most cats treated with econazole cream revealed redness and irritation of the skin at the site of application. This study demonstrates that terbinafine tended to have superior clinical efficacy (p<0.001) in the treatment of dermatophytosis in cats compared to the azole tested.

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2016
• Tom: 19
• Numer: 3
• Opis fizyczny: p.535-543,fig.,ref.

Twórcy

autor

Iwaskiene M.

• Laboratory of Experimental and Clinical Pharmacology, Department of Non-Infectious Diseases, Lithuanian University of Health Sciences, Veterinary Academy, Tilzes 18, LT-47181 Kaunas, Lithuania

autor

Matusevicius A.P.

• Laboratory of Experimental and Clinical Pharmacology, Department of Non-Infectious Diseases, Lithuanian University of Health Sciences, Veterinary Academy, Tilzes 18, LT-47181 Kaunas, Lithuania

autor

Grigonis A.

• Dr. L Kriauceliunas Small Animal Clinics, Lithuanian University of Health Sciences, Veterinary Academy, Kaunas, Lithuania

autor

Zamokas G.

• Dr. L Kriauceliunas Small Animal Clinics, Lithuanian University of Health Sciences, Veterinary Academy, Kaunas, Lithuania

autor

Babickaite L.

• Dr. L Kriauceliunas Small Animal Clinics, Lithuanian University of Health Sciences, Veterinary Academy, Kaunas, Lithuania

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Identyfikatory

DOI

10.1515/pjvs-2016-0067