Effects of repeated administration of cannabidiol on body weight gain, food intake and accumulation of adipose tissue in rats

• Autorzy: Ignatowska-Jankowska B. , Jankowski M. , Torczynska A. , Kurrek A. , Swiergiel A.
• Języki publikacji: EN

Abstrakty

EN

Cannabidiol (CBD) is a major non-psychotropic compound derived from Cannabis that has wide therapeutic potential. In our previous studies we observed decreased body weight gain in rapidly growing rats (10 weeks of age at the start of study) treated with CBD for 14 consecutive days. The present study aimed to evaluate the effects of repeated CBD administration on body weight gain, food intake and accumulation of abdominal adipose tissue in rats fed standard (SD) and high fat (HFD) diet. Adult male Wistar rats (n = 36) weighing approximately 400 g at the beginning of the experiment (14 weeks of age), fed with SD only, or having access to free choice HFD (60% kcal from fat, 10% kcal from sucrose) received intraperitoneal injections of CBD or vehicle for 14 consecutive days (5 mg/kg/day). Body weight gain as well as food and water intake were measured daily. Total amount of intra-abdominal adipose tissue was assessed by a dissection method. In contrast to previous observations in younger rats, repeated CBD administration induced significant increase in body weight gain of rats fed SD, but no significant change in food or water intake was observed. CBD produced tendency for decreased body weight gain in rats fed with HFD, but it did not reach level of significance. CBD did not affect total energy intake in rats that had access to HFD, but slightly increased preference for SD. CBD administration reduced intra-abdominal adipose tissue accumulation in rats with access to HFD, but not in rats fed with SD only. The results suggest that CBD may produce different effects on body weight gain depending on age or the metabolic state of the animal. Moreover, the results indicate that CBD may decrease accumulation of intra-abdominal adipose tissue in animals under HFD.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2011
• Tom: 71
• Numer: S
• Opis fizyczny: p.59

Twórcy

autor

Ignatowska-Jankowska B.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Jankowski M.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Torczynska A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Kurrek A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

autor

Swiergiel A.

• Department of Animal Physiology, University of Gdansk, Gdansk, Poland

Uwagi

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