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2011 | 55 | 2 |

Tytuł artykułu

Expression of IGF1, IGF1R, and SP1 factors in HPV infected cervical cancer cells

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The aim of the study was to investigate the mRNA expression levels of IGF1, IGF1R, and SP1 in cervical epithelial cells in different stages of cervical cancerogenesis using real-time PCR. The analysis indicated up-regulation of IGF1 gene expression in L- SIL and H-SIL, followed by its down-regulation in cervical cancer. Firstly, the obtained results suggest that IGF1 can be recognised asan essential factor in cervical cancerogenesis; secondly the SP1 action may be crucial for IGF1 expression.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

55

Numer

2

Opis fizyczny

p.281-286,fig.,ref.

Twórcy

  • Department of Obstetrics and Gynecology, Medical University, 20-081 Lublin, Poland

Bibliografia

  • 1. Chitnis M.M., Yuen J.S., Protheroe A.S., Pollak M., Macaulay V.M.: The type 1 insulin-like growth factor receptor pathway. Clin Cancer Res 2008, 14, 6364-6370.
  • 2. Chong Y.M., Colston K., Jiang W.G., Sharma A.K., Mokbel K.: The relationship between the insulin-like growth factor-1 system and the oestrogen metabolising enzymes in breast cancer tissue and its adjacent non-cancerous tissue. Breast Cancer Res Treat 2006, 99, 275-288.
  • 3. Daud I.I., Scott M.E.: Validation of reference genes in cervical cell samples from human papillomavirus- infected and uninfected women for quantitative reverse transcription-PCR assays. Clin Vaccine Immunol 2008, 15, 1369-1373.
  • 4. Doorbar J.: Molecular biology of human papillomavirus infection and cervical cancer. Clin Sci (London) 2006, 110, 525-541.
  • 5. Gloss B., Bernard H.U.: The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Spl distal element. J Virol 1990, 64, 5577-5584.
  • 6. Grabe N.: AliBaba2: context specific identification of transcription factor binding sites. In Silico Biol 2002, 2, S1-S15.
  • 7. Hartog H., Wesseling J., Boezen H.M., van der Graaf W.T.: The insulin-like growth factor 1 receptor in cancer: old focus, new future. Eur J Cancer 2007, 43, 1895-1904.
  • 8. Jones J.I., Clemmons D.R., Insulin-like growth factors and their binding proteins: biological actions. Endocrinol Rev 1995, 16, 3-34.
  • 9. Jozefiak A., Pacholska-Bogalska J., Myga-Nowak M., Kedzia W., Kwasniewska A., Luczak M., Kedzia H., Gozdzicka-Jozefiak A.: Serum and tissue levels of insulin-like growth factor-I in women with dysplasia and HPV-positive cervical cancer. Mol Med Report 2008, 1, 231-237.
  • 10. Kuramoto H., Hongo A., Liu Y., Ojima Y., Nahamura K., Seki N., Kodama J., Hiramatsu Y.: Immunohistochemical evaluation of insulin-like growth factor 1, receptor status in cervical cancer speciments. Acta Med Okayama 2008, 62, 251-259.
  • 11. Li B., Wang X., Zhou F., Saunders N.A., Frazer I.H., Zhao K.N.: Up-regulated expression of Spl protein coincident with a viral protein in human and mouse differentiating keratinocytes may act as a cell differentiation marker. Differentiation 2008, 76, 1068- 1080.
  • 12. Li T., Chen Y.H., Liu T.J., Jia J., Hampson S., Shan Y.X., Kibler D., Wang P.H.: Using DNA microarray to identify Spl as a transcriptional regulatory element of insulin-like growth factor 1 in cardiac muscle cells. Circ Res 2003, 93, 1202-1209.
  • 13. Madkan V.K., Cook-Norris R.H., Steadman M.C., Arora A., Mendoza N., Tyring S.K.: The oncogenic potential of human papillomaviruses: a review on the role of host genetics and environmental cofactors. Br J Dermatol 2007, 157, 228-241.
  • 14. Maloney E.K., McLaughlin J.L., Dagdigian N.E., Garrett L.M., Connors K.M., Zhou X.M., Blättler W.A., Chittenden T., Singh R.: An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation. Cancer Res 2003, 63, 5073- 5083.
  • 15. Mannhardt B., Weinzimer S.A., Wagner M., Fiedler M., Cohen P., Jansen-Dürr P., Zwerschke W.: Human papillomavirus type 16 E7 oncoprotein binds and inactivates growth-inhibitory insulin-like growth factor binding protein 3. Mol Cell Biol 2000, 20, 6483-6495.
  • 16. Nakamura K., Hongo A., Kodama J., Miyagi Y., Yoshinouchi M., Kudo T.: Down-regulation of the insulin-like growth factor I receptor by antisense RNA can reverse the transformed phenotype of human cervical cancer cell lines. Cancer Res 2000, 60, 760-765.
  • 17. Pollak M.: Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008, 8, 915- 928.
  • 18. Riedemann J., Macaulay V.M.: IGF1R signalling and its inhibition. Endocr Relat Cancer 2006, 13 Suppl 1, S33- S43.
  • 19. Serrano M.L., Sánchez-Gómez M., Bravo M.M.: Insulin-like growth factor system gene expression in cervical scrapes from women with squamous intraepithelial lesions and cervical cancer. Growth Horm IGF Res 2007, 17, 492-499.
  • 20. Shen M.R., Hsu Y.M., Hsu K.F., Chen Y.F., Tang M.J., Chou C.Y.: Insulin-like growth factor 1 is a potent stimulator of cervical cancer cell invasiveness and proliferation that is modulated by αvß3 integrin signaling. Carcinogenesis 2006, 27, 962-971.
  • 21. Tan N.Y., Khachigian L.M.: Spl phosphorylation and its regulation of gene transcription. Mol Cell Biol 2009, 29, 2483-2488.
  • 22. Vashisth H., Abrams C.F.: All-atom structural models for complexes of insulin-like growth factors IGF1 and IGF2 with their cognate receptor. J Mol Biol 2010, 400, 645-658.
  • 23. Werner H., Shalita-Chesner M., Abramovitch S., Idelman G., Shaharabani-Gargir L., Glaser T.: Regulation of the insulin-like growth factor-I receptor gene by oncogenes and antioncogenes: implications in human cancer. Mol Genet Metab 2000, 71, 315-320.
  • 24. Weber M.M., Fottner C., Liu S.B., Jung M.C., Engelhardt D., Baretton G.B.: Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 2002, 95, 2086-2095.
  • 25. Yu H., Rohan T.: Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 2000, 92, 1472-1489.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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