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1989 | 40 | 5-6 |
Tytuł artykułu

Studies on the mechanism of obstructive sleep apnea

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Kukwa, A., Gromysz, H., Jernajczyk, U. and Karczewski, W. A.: Studies on the mechanism of obstructive sleep apnea. Acta physiol, pol., 1989, 40(5-6): 473-478. Several observations indicate that the mylohyoid nerve (NV) may play a crucial part in the mechanisms of obstructive sleep apnea (OSA). The activity of this nerve normally counteracts the collapse of the upper airways during inspiration. Any reduction in this activity may thus facilitate the occurrence of apnoeic spells. We have studied the effects of ethanol and lung inflations on the activity of NV recorded along with the activities of phrenic and facial nerve in rabbits anaesthetised with chloralose-urethan, paralyzed with curare and artificially ventilated. Under the control conditions the NV exhibited phasic expiratory activity; after vagotomy and additional, inspiratory component was observed. Lung inflation strongly enhanced the expiratory activity of NV whereas both the phrenic and facial nerve activities (both phasic-inspiratory) were typically inhibited. An injection of 5 ml of 20% ethanol very strongly inhibited the NV activity. The results may confirm the importance of NV in the mechanism of OSA. The well-known fact that OSA patients are particularly sensitive to alcohol finds support in the response of NV activity to ethanol injection. The analysis of the patterns of discharges of the three outputs from the respiratory controller may additionally suggest that the Vth nerve nucleus is involved in the control of respiratory pattern.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
40
Numer
5-6
Opis fizyczny
p.473-478,fig.,ref.
Twórcy
autor
  • Medical Research Centre, Department of Neurophysiology, Polish Academy of Sciences, Warsaw, Poland
autor
  • Medical Research Centre, Department of Neurophysiology, Polish Academy of Sciences, Warsaw, Poland
  • Medical Research Centre, Department of Neurophysiology, Polish Academy of Sciences, Warsaw, Poland
  • Medical Research Centre, Department of Neurophysiology, Polish Academy of Sciences, Warsaw, Poland
Bibliografia
  • 1. Brouilette, R. T., Thach, В. T. (1979) A neuromuscular mechanism maintaining extra- thoracic airway patency. J. Appl. Physiol. 46. 772-779.
  • 2. Coccagna, C.f Cirignotta, F., Lugaresi, E. (1978) The bird-like face syndrome (acquired micrognathia, hypersomnia, and sleep apnea). In: C. Guilleminault, W. C. Dement, Sleep apnea syndrome. Alan R. Liss eds., New York, pp. 259-271.
  • 3. De Berry-Borowiecki, B., Kukwa, A., Blanks, R. H. I. (1985) Indications for palatopharyngoplasty. Arch. Otolaryngol. 111. 659-663.
  • 4. Issa, F. G., Sullivan, С. E. (1982) Alcohol, snoring and sleep apnoea. J. Neurosurg. Psychiatry 45. 353-359.
  • 5. McNicholas, W. T., Tarlo, S., Cole, Ph., Zamel, N., Rutherford, R., Griffin, D., Phillipson, E. A. (1982) Obstructive apneas during sleep in patients with seasonal allergic rhinitis. Am. Rev. Respir. Dis 126. 625-628.
  • 6. Patton, T. J., Thawley, S. E., Waters, R. C., Vandermeer, P. J., Ogura, J. H. (1983) Expansion hyoideoplasty: a potential surgical procedure designed for selected patients with obstructive sleep apnea syndrome. Experimental canine reults. Laryngoscope 93. 1387-1395.
  • 7. Remmers, J. E., de Groot, W. J., Sauerland, E. K., Anch, A. M. (1978) Pathogenesis of the upper airway occlusion during sleep. J. Appl. Physiol. 44. 931-938.
  • 8. Riley, R., Guilleminault, C., Heran, J., Powell, N. (1983) Cephalometric analysis and flow-volume loops in obstructive sleep apnea patients. Sleep 6. 303-311.
  • 9. St. John, W. M., Bledsoe, T. A. (1985) Comparison of respiratory-related trigeminal, hypoglossal and phrenic activities. Resp. Physiol. 62. 61-78.
  • 10. Steinschneider, A. (1975) Nasopharyngitis and prolonged sleep apnea. Pediatrics 56. 967-971.
  • 11. Weitzman, E. D., Pollack, С. P., de Berry-Borowiecki, B. (1978) Hypersomnia sleep apnea syndrome due to micrognathia. Reversal by tracheoplasty. Arch. Neurol. 35. 392-395.
Typ dokumentu
Bibliografia
Identyfikatory
Identyfikator YADDA
bwmeta1.element.agro-326915fc-e42d-4f5d-b565-f413982e0ffd
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