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1990 | 41 | 7 |
Tytuł artykułu

Intracerebroventricular insulin affects the neurohypophysial vasopressin content in euhydrated and dehydrated rats

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Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
Stempniak В. and Guzek J. W.: Intracerebroventricular insulin affects the neurohypophysial vasopressin content in euhydrated and dehydrated rats. Acta Physiol. Pol., Rats euhydrated or dehydrated for four days were given intracerebroventricular insulin once daily in a dose of 100 ng (not affecting blood sugar level). In euhydrated rats, insulin decreased significantly the neurohypophysial vasopressin content. In dehydrated animals the neurohypophysial content depleted by deprivation of water could be further reduced by intracerebroventricular treatment with insulin. These results may suggest a possible regulatory role of brain insulin in the mechanisms of vasopressin release.
Wydawca
-
Rocznik
Tom
41
Numer
7
Opis fizyczny
p.48-53,fig.,ref.
Twórcy
autor
  • Department of Pathophysiology, School of Medicine, Narutowicza 60, 90-136 Lodz, Poland
autor
  • Department of Pathophysiology, School of Medicine, Narutowicza 60, 90-136 Lodz, Poland
Bibliografia
  • 1. Baskin D. G., Porte D. Ir., Guest, Karen, Dorsa D. M. (1983): Regional concentrations of insulin in the rat brain. Endocrinology, 112, 898-903.
  • 2. Bernstein H. G., Schwarzberg H., Reiser M., Günther O., Dorn A. (1986): Intracerebroventricular infusion of insulin alters the behaviour of rats not related to food intake. Endocrinol. Exper., 20, 387-392
  • 3. Gaddum J. H. (1953): Bioassays and mathematics. Pharmacol. Rev., 5, 87-134.
  • 4. Guzek J. W. (1984): Central nervous system mediators and modulators of vasopressin and oxytocin release (in Polish). Acta Physiol. Pol., 35, 3-32.
  • 5. Guzek J. W., Lewandowska A., Stempniak B. (1988): Insulin and release of neurohypophysial hormones: in vivo and in vitro studies. Exp. Clin. Endocrinol., 92, 43-50.
  • 6. Guzek J. W., Orłowska-Majdak M., Wdzięczak J. (1976): The vasopressin and oxytocin content in the hypothalamus and neurohypophysial as influenced by reserpine treatment during long-term dehydration in the with rat. Endokrinologie, 67, 36-50.
  • 7. Hyvärinen A., Nikkila E. A. (1962): Specific determination of blood glucose with o-toluidine. Clin. Chim. Acta, 7, 140-143.
  • 8. Kleinrok Z., Ossowska G., Stelmasiak M., Juszkiewicz M. (1983): The influence of insulin hypoglycemia on central dopaminergic structures of the rat. Pol. J. Pharmacol. Pharm., 35, 489-495.
  • 9. Kozłowski S., Szczepańska-Sadowska E., Sobocińska J., Bąk M., Czyżyk A. (1980): Stimulation of thirst and ADH release after intracranial injection of insulin in the dbg. Verh. der deutschen Ges. f. inn. Med., 86, 1423-1426.
  • 10. Krieger D. T. (1983): Brain peptides: what, where, and why? Science, 222, 975-985.
  • 11. Mackenzie R. G., Trulson M. E. (1978): Effects of insulin and streptozotocin-induced diabetes on brain tryptophan and serotonin metabolism in rats. J. Neurochem., 30, 205-211.
  • 12. Moses A. M., Miller M. (1974): Osmotic influences on the release of vasopressin. In: The pituitary gland and its neuroendocrine control (Handbook of physiology, section 1, vol. IV). Eds.: E. Knobil and R. C. Greep, American Physiological Society, Washington, 225-243.
  • 13. Sklar A. H., Schrier R. W. (1983): Central nervous system mediators of vasopressin release. Physiol. Rev., 63, 1243-1280.
  • 14. Underhill L. H., Rosenzweig J. L., Roth J., Brownstein M. J., Scott Young W., Havrankova J. (1982): Insulin and insulin receptors in the nervous system of mammals. Front. Horm. Res., 10, 96-110.
  • 15. Wysmyk-Cebula U., Albrecht J. (1981): Zawartość GABA oraz aktywność Gad w mózgu szczura w warunkach doświadczalnej hipoglikemii. Neuropat Pol., 3, 369-376.
  • 16. Young W. S., Kuchar M. J., Roth J., Brownstein M. J. (1980) Radiohistochemical localization of insulin receptors in the adult and developing rat brain. Neuropeptides, 1, 15-22.
  • 17. Zahnister N. R., Goens M. B., Hanaway P. J., Vinych J. V. (1984): Characterization and regulation of insulin receptors in rat brain. J. Neurochem., 42, 1354-1362.
Typ dokumentu
Bibliografia
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