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2011 | 71 | 2 |

Tytuł artykułu

Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
To investigate how cognitive impairment is affected by the relief of bilateral carotid stenosis, chronic cerebral hypoperfusion was established through stenosis of the bilateral carotid common artery in adult Sprague-Dawley rats. Subsequently, the model rats received the intragastric placebo, donepezil (5 mg/kg), or surgery to relieve carotid stenosis after bilateral carotid common artery stenosis. After carotid stenosis was relieved, the cerebral blood flow values significantly increased, and P300 latency and escape latency in the Morris water-maze were significantly shortened. The concentrations of acetylcholine and norepinephrine in the dorsal hippocampus increased after carotid stenosis was relieved. Furthermore, P300 latency and escape latency were shortened in the relief-treated group compared to the drug-treated group, and acetylcholine levels in the relief-treated group were higher than the drug-treated group. No significant difference was found for the norepinephrine levels in the dorsal hippocampus between the relief-treated and drug-treated groups. Cognitive impairment can be significantly reduced by bilateral carotid stenosis relief, and the effect of relieving stenosis on cognitive dysfunction is superior to the effect of administering an acetylcholinesterase inhibitor.

Słowa kluczowe

Wydawca

-

Rocznik

Tom

71

Numer

2

Opis fizyczny

p.233-243,fig.,ref.

Twórcy

autor
  • Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China
  • Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
autor
  • Department of Neurosurgery, Xinqiao Hospital, Third Military Medical University, Chongqing, China
autor
  • Department of Neurology, Xinqiao Hospital, Third Military Medical University, Chongqing, China
autor
  • Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China
autor
  • Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China
autor
  • Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China

Bibliografia

  • Aleksic M, Huff W, Hoppmann B, Heckenkamp J, Pukrop R, Brunkwall J (2006) Cognitive function remains unchanged after endarterectomy of unilateral internal carotid artery stenosis under local anaesthesia. Eur J Vasc Endovasc Surg 31: 616-621. Black S, Roman GC, Geldmacher DS, Salloway S, Hecker J, Burns A, Perdomo C, Kumar D, Pratt R (2003) Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial. Stroke 34: 2323-2330.
  • Chamberlain SR, Muller U, Robbins TW, Sahakian BJ (2006) Neuropharmacological modulation of cognition. Curr Opin Neurol 19: 607-612.
  • Court JA, Perry EK (2003) Neurotransmitter abnormalities in vascular dementia. Int Psychogeriatr 15 Suppl 1: 81-87.
  • De Rango P, Caso V, Leys D, Paciaroni M, Lenti M, Cao P (2008) The role of carotid artery stenting and carotid endarterectomy in cognitive performance: a systematic review. Stroke 39: 3116-3127.
  • Dichgans M, Markus HS, Salloway S, Verkkoniemi A, Moline M, Wang Q, Posner H, Chabriat HS (2008) Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL. Lancet Neurol 7: 310-318.
  • Erkinjuntti T, Gauthier S (2009) The concept of vascular cognitive impairment. Front Neurol Neurosci 24: 79-85. Erkinjuntti T, Roman G, Gauthier S, Feldman H, Rockwood K (2004) Emerging therapies for vascular dementia and vascular cognitive impairment. Stroke 35: 1010-1017.
  • Fearn SJ, Hutchinson S, Riding G, Hill-Wilson G, Wesnes K, McCollum CN (2003) Carotid endarterectomy improves cognitive function in patients with exhausted cerebrovascular reserve. Eur J Vasc Endovasc Surg 26: 529-536.
  • Gill SS, Rochon PA (2004) Review: donepezil improves cognitive and functional outcomes in vascular cognitive impairment. ACP J Club 141: 39.
  • Gliebus G, Lippa CF (2007) The influence of beta-blockers on delayed memory function in people with cognitive impairment. Am J Alzheimers Dis Other Demen 22: 57-61.
  • Gottfries CG, Blennow K, Karlsson I, Wallin A (1994) The neurochemistry of vascular dementia. Dementia 5: 163­167.
  • Jellinger KA (2008) The pathology of "vascular dementia": a critical update. J Alzheimers Dis 14: 107-123.
  • Johnston SC, O'Meara ES, Manolio TA, Lefkowitz D, O'Leary DH, Goldstein S, Carlson MC, Fried LP, Longstreth WT Jr (2004) Cognitive impairment and decline are associated with carotid artery disease in patients without clinically evident cerebrovascular dis­ease. Ann Intern Med 140: 237-247.
  • Kavirajan H, Schneider LS (2007) Efficacy and adverse effects of cholinesterase inhibitors and memantine in vas­cular dementia: a meta-analysis of randomised controlled trials. Lancet Neurol 6: 782-792.
  • Kim VB, Brown PM, Brown PM, Jr., Sun YS, Lust RM, Chitwood WR Jr (2001) A carotid stenosis model in canines. J Invest Surg 14: 241-247.
  • Kosasa T, Kuriya Y, Matsui K, Yamanishi Y (2000) Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cho­linesterase activity in rats. Eur J Pharmacol 389: 173-179.
  • Lal BK (2007) Cognitive function after carotid artery revas- cularization. Vasc Endovascular Surg 41: 5-13.
  • Launer LJ, Hofman A (2000) Frequency and impact of neu­rologic diseases in the elderly of Europe: A collaborative study of population-based cohorts. Neurology 54: S1-S8.
  • Lee JH, Park SY, Shin YW, Kim CD, Lee WS, Hong KW (2007) Concurrent administration of cilostazol with done- pezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoper- fusion in rats. Brain Res 1185: 246-255.
  • Liang Y, Li S, Zou Q, Su B (2006) Potential neuroprotective effect of low dose whole-body gamma-irradiation against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)- induced dopaminergic toxicity in C57 mice. Neurosci Lett 400: 213-217.
  • Mathiesen EB, Waterloo K, Joakimsen O, Bakke SJ, Jacobsen EA, Bonaa KH (2004) Reduced neuropsycho- logical test performance in asymptomatic carotid steno­sis: The Tromso Study. Neurology 62: 695-701.
  • Mendez MF, Shapira JS, McMurtray A, Licht E (2007) Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia. Am J Geriatr Psychiatry15: 84-87.
  • Meyer JS, Rauch G, Rauch RA, Haque A (2000) Risk factors for cerebral hypoperfusion, mild cognitive impairment, and dementia. Neurobiol Aging 21: 161-169.
  • Mlekusch W, Mlekusch I, Haumer M, Kopp CW, Lehrner J, Ahmadi R, Koppensteiner R, Minar E, Schillinger M (2008) Improvement of neurocognitive function after protected carotid artery stenting. Catheter Cardiovasc Interv 71: 114-119.
  • Moftakhar R, Turk AS, Niemann DB, Hussain S, Rajpal S, Cook T, Geraghty M, Aagaard-Kienitz B, Turski PA, Newman GC (2005) Effects of carotid or vertebrobasilar stent placement on cerebral perfusion and cognition. AJNR Am J Neuroradiol 26: 1772-1780.
  • Morris R (1984) Developments of a water-maze procedure for studying spatial learning in the rat. J Neurosci Methods 11: 47-60.
  • NASCETC (1991) Beneficial effect of carotid endarterec- tomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collaborators. N Engl J Med 325: 445-453.
  • Parnetti L, Reboldi GP, Santucci C, Santucci A, Gaiti A, Brunetti M, Cecchetti R, Senin U (1994) Platelet MAO-B activity as a marker of behavioural character­istics in dementia disorders. Aging (Milano) 6: 201­207.
  • Paxinos G, Watson C (1998) The rat brain in stereotaxic coordinates. Academic Press, New York, NY.
  • Rebola N, Lujan R, Cunha RA, Mulle C (2008) Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57: 121-134.
  • Rojas-Fernandez CH, Moorhouse P (2009) Current concepts in vascular cognitive impairment and pharmacotherapeu- tic implications. Ann Pharmacother 43: 1310-1323.
  • Roman G (2000) Perspectives in the treatment of vascular dementia. Drugs Today (Bare) 36: 641-653.
  • Sanchez-Aijona MB, Sanz-Fernandez G, Franco-Macias E, Gil-Peralta A (2007) Cerebral hemodynamic changes after carotid angioplasty and stenting. AJNR Am J Neuroradiol 28: 640-644.
  • Schuck S, Bentue-Ferrer D, Kleinermans D, Reymann JM, Polard E, Gandon JM, Allain H (2002) Psychomotor and cognitive effects of piribedil, a dopamine agonist, in young healthy volunteers. Fundam Clin Pharmacol 16: 57-65.
  • Soinne L, Helenius J, Tikkala I, Saimanen E, Salonen O, Hietanen M, Lindsberg PJ, Kaste M, Tatlisumak T (2009) The effect of severe carotid occlusive disease and its sur­gical treatment on cognitive functions of the brain. Brain Cogn 69: 353-359.
  • Sztriha LK, Nemeth D, Sefcsik T, Vecsei L (2009) Carotid stenosis and the cognitive function. J Neurol Sci 283: 36-40.
  • Tohgi H, Ueno M, Abe T, Takahashi S, Nozaki Y (1992) Concentrations of monoamines and their metabolites in the cerebrospinal fluid from patients with senile dementia of the Alzheimer type and vascular dementia of the Binswanger type. J Neural Transm Park Dis Dement Sect 4: 69-77.
  • van Laar PJ, van der Grond J, Moll FL, Mali WP, Hendrikse J (2006) Hemodynamic effect of carotid stenting and carotid endarterectomy. J Vasc Surg 44: 73-78.
  • Wallin A, Blennow K, Edman A, Mansson JE (1996) Decreased lumbar cerebrospinal fluid levels of monoam- ine metabolites in vascular dementia. Int Psychogeriatr 8: 425-436.
  • Wilkinson D, Doody R, Helme R, Taubman K, Mintzer J, Kertesz A, Pratt RD (2003) Donepezil in vascular demen­tia: a randomized, placebo-controlled study. Neurology 61: 479-486.

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Bibliografia

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