Związki halogenoorganiczne – stare i nowe zagrożenia dla ludzi

• Autorzy: Goralczyk K. , Hernik A. , Czaja K. , Strucinski P. , Korcz W. , Snopczynski T. , Ludwicki J. K.

Warianty tytułu

EN

Organohalogen compounds – new and old hazards for people

• Języki publikacji: PL

Abstrakty

PL

Związki halogenoorganiczne (pestycydy chloroorganiczne, PCB, PBDE) są trwałymi zanieczyszczeniami organicznymi (TZO) szeroko rozpowszechnionymi w środowisku. Ich stabilność fizyko-chemiczna i lipofilność są odpowiedzialne za kumulowanie się tych związków w organizmach ludzkich. Żywność, zwłaszcza pochodzenia zwierzęcego, jest głównym źródłem narażenia populacji generalnej na pestycydy chloroorganiczne i PCB. Natomiast podstawowym źródłem narażenia człowieka na PBDE jest również żywność, ale także kurz lub frakcja respirabilna powietrza w pomieszczeniach zamkniętych. Trwałe zanieczyszczenia organiczne należące to tej grupy związków są obecne w różnych stężeniach w tkance tłuszczowej, wątrobie, łożysku, a nawet we krwi i mleku kobiecym. Związki halogenoorganiczne mogą zakłócać homeostazę układu hormonalnego i wchodzić w reakcje jako antagoniści lub agoniści z receptorami androgenowymi, estrogenowymi lub progesteronowymi. Większość z tych związków wykazuje właściwości antyandrogenne, estrogenne i antyestrogenne.

EN

The organohalogen compounds (OCs, PCBs, PBDEs) are persistent organic pollutants (POPs) that have a widespread distribution in the environment. Their chemico-physical stability and lipophylic properties are responsible for their accumulation in the human body. The general human population is exposed to PCBs and OCs through foodstuffs, mainly food of animal origin. However, the main source of the human exposure to PBDEs are also food and inhalation of dust or respirable phase of the indoor air. The POPs from this group are present on different levels in human tissues (fat tissue, liver, placenta), and even in human blood and breast milk. The organohalogen compounds may cause endocrine disrupting (ED) effects as they have been shown to interact as antagonists or agonists with androgen, progesterone, and estrogen receptors. Most of them shows antiandrogenic, estrogenic and antiestrogenic activity.

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2010
• Tom: 61
• Numer: 2
• Opis fizyczny: s.109-117,tab.,bibliogr.

Twórcy

autor

Goralczyk K.

• Zakład Toksykologii Środowiskowej, Narodowy Instytut Zdrowia Publicznego – Państwowy Zakład Higieny w Warszawie, ul.Chocimska 24, 00-791 Warszawa

autor

Hernik A.

autor

Czaja K.

autor

Strucinski P.

autor

Korcz W.

autor

Snopczynski T.

autor

Ludwicki J. K.

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