Embryotoxic effects of chlorfenvinphos and bromfenvinphos in laboratory animals

• Autorzy: Dzierzawski A. , Minta M.
• Języki publikacji: EN

Abstrakty

EN

The experiments were carried out on 94 hamster females (765 live foetuses), 78 rats (724 foetuses) and 32 rabbits (237 foetuses). The commercial chlorfenvinphos (2-chloro-1-/2,4-dichlorphenyl/vinyl diethyl phosphate) and bromfenvinphos (2-bromo-1-/2-4-dichlorphenyl/vinyl diethyl phosphate) preparation were administered p.o., once or three times to pregnant animals in rape oil during the time of organogenesis. The animals were sacrificed two days before the term, and foetuses were examined according to experimental designs adopted for teratogenic studies. The results obtained indicate that bromfenvinphos possesses weaker embryotoxic properties than does chlorfenvinphos. No teratogenic action of bromfenvinphos for hamster and rat foetuses has been found while chlorfenvinphos induced sporadic developmental abnormalities in hamster and rabbit foetuses.

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 1979
• Tom: 23
• Numer: 1-2
• Opis fizyczny: p.32-41,fig.,ref.

Twórcy

autor

Dzierzawski A.

• Department of Pharmacology and Toxicology, The Veterinary Research Institute, Pulawy, Poland

autor

Minta M.

• Department of Pharmacology and Toxicology, The Veterinary Research Institute, Pulawy, Poland

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