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2019 | 79 | Suppl.1 |

Tytuł artykułu

Investigation into the effects of chronic antidepressant and acute ketamine treatment on ultrasonic vocalisations in Wistar-Kyoto and Sprague-Dawley rats

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INTRODUCTION: The emission of ultrasonic vocalisation (USVs) is thought to be a major means of rat communication that can be affected by a wide range of stimuli. 55 kHz USVs are emitted in response to various positive/ pleasurable situations and are considered to reflect an underlying positive affective state. Wistar‑Kyoto (WKY) rats are an endogenous model of treatment-resistant depression (TRD), resistant to selective serotonin reuptake inhibitors (SSRIs) but responsive to ketamine. AIM(S): The aims of this study were firstly to compare baseline USVs emission in WKY rats to an outbred Sprague‑Dawley (SD) strain and to evaluate the effect of different classes of antidepressant drugs on USVs profile. METHOD(S): WKY and SD rats were subjected to chronic vehicle (NaCl 0.9%, s.c.), fluoxetine (10 mg/kg, s.c.), desipramine (10 mg/kg, s.c.), or acute ketamine (5 mg/kg, s.c.) treatment followed by USVs recording in the home cage. An additional group of non‑injected rats was included in the study. All recordings (Sonotrack, Metris) were taken for a total of 5 min at four different time points: 30 min (no ketamine), 24 h, 7 days, and 21 days of administration. A number of 55 kHz calls was analysed. RESULTS: Overall, WKY rats emitted more 55 kHz calls when compared with SD rats. Chronic treatment with a commonly used antidepressant, fluoxetine, resulted in a persistent decrease in the number of “positive” calls at all time points when evaluated in WKY rats. In SD rats, a similar decrease was observed only during the first two days of drug administration. Chronic desipramine treatment had no effect on the number of 55 kHz calls, in either strain, when compared to vehicle group. Acute ketamine administration to WKY rats resulted in a decrease in a number of “positive” calls at 24 h but not at 7 or 21 days post‑administration. CONCLUSIONS: This study demonstrates a potential application of USVs recording as a relevant behavioural parameter that can be included in studies that investigate the effect of long-term and acute drug exposure on changes in emotionality.

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  • Transpharmation Ireland Ltd.
  • Transpharmation Ireland Ltd.
  • Transpharmation Ireland Ltd.
  • Transpharmation Ireland Ltd.


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