Modulowanie odpowiedzi immunologicznej przez inwazje pasożytnicze

• Autorzy: Bany J.

Warianty tytułu

EN

Modulation of immunological response by parasitic invasion

• Języki publikacji: PL

Abstrakty

EN

The objective of the study was the phenotypic characteristics of thymocytes and T-lymphocytes and the evaluation of T cell function in the course of experimental trichinellosis in mice. It was found that the cortical part of the thymus was significantly diminished and the expression of Thy, Ly1 and Ly2 antigens were decreased during the intestinal phase of the parasitic invasion. Simultaneously, the increase of Thy⁺ bearing cells was observed in peripheral lymphatic tissue (spleen and lymph nodes) during this and the next early muscular phase of the invasion of T. spiralis. The expression of L3T4 and Ly2 antigens was also higher than or at least the same as in the control animals. The results of the evaluation of T lymphocytes reactivity show that the parasitic invasion results in changes in cellular immunity as was demonstrated by GvH reactions. These changes are dependent on both the intensity of the parasitic invasion and the phase of infection. The possible mechanisms of the modulation (stimulation or inhibition) of host immunity were discussed.

Słowa kluczowe

PL

parazytologia; pasozyty; inwazja pasozytnicza; odpowiedz immunologiczna; stymulacja odpornosci; immunoregulacja; immunoparazytologia

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 1988
• Tom: 34
• Numer: 4-6
• Opis fizyczny: s.497-501,rys.,bibliogr.

Twórcy

autor

Bany J.

• Wojskowy Instytut Higieny i Epidemiologii w Warszawie, Warszawa

Bibliografia

• 1. Finnegan, A., Berzofsky, J. A.: Antigen recognition by T cells. - Immunol. Today, 7, 317-319, 1986.
• 2. Grencis, R. K., Riedlinger, J., Wakelin, D.: L3T4 - positive T lymphoblasts are responsible for transfer of immunity Trichinella spiralis in mice. - Immunology, 56, 213-218, 1985.
• 3. Herscowitz, H. B.: Immunophysiology: Cell Function and Cellular Interactions in Antibody Formation., W: ,,Immunology III", Red. Bellanti, J. A., W. B. Saunders Company rozdz. 7, 117-159, 1985.
• 4. Hodes, R. J.: Lyt antigens as markers for functional T cell subpopulations. - Immunol. Today, 3, 235-239, 1982.
• 5. Krco, J. Ch., David, S. Ch., Wassom, D. L.: Characterization of an in vitro Proliferation Response to Solubilized Trichinella spiralis Antigens: Role of la Antigens and Ly1⁺ T cells. - Cell. Immunol., 68, 359-367, 1982.
• 6. Riedlinger, J., Grencis, R. K., Wakelin, D.: Antigen – specific T - cell lines transfer protective immunity against Trichinella spiralis in vivo. - Immunology, 58, 57-61, 1986.
• 7. Sprent, J., Schaefer, M., Lo, D., Korngold, R.: Functions or Purified L3T4⁺ and Lyt-2⁺ Cells in vitro and in vivo. Immunol. Rev., 91, 195-218, 1986.
• 8. Wassom, L. D., Krco, J. Ch., David, S. Ch.: I-E expression and susceptibility to parasite infection. - Immunol. Today, 8, 39-43, 1987.