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2012 | 59 | 4 |
Tytuł artykułu

Biased versus unbiased randomness in homo-polymers and copolymers of amino acids in the prebiotic world

Treść / Zawartość
Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
 The polymerization of amino acids under anhydrous prebiotic conditions was first studied several decades ago. Here we use a stochastic model stressing the relevant role of the polarity of amino acids in the formation of oligopeptides in a prebiotic milieu. Our goal is to outline the predominance of co-polypeptides over homo-polypeptides, resulting not only from the randomness, but also from polarity properties of amino acids. Our results conclude that there was a higher probability of the formation of co-polypeptides than of homo-polymers. Besides, we may hypothesize that the former would have a more ample spectrum of possible chemical functions than homo-polypeptides.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
59
Numer
4
Opis fizyczny
p.543-547,fig.,ref.
Twórcy
  • Direccion General de Divulgacion de la Ciencia, Universidad Nacional Autonoma de Mexico, Mexico
autor
  • Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de México, Mexico
autor
  • Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de México, Mexico
autor
  • Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de México, Mexico
  • Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
  • Subdireccion de Epidemiologia Hospitalaria y Control de Calidad de la Atencion Medica, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, México
Bibliografia
  • Bruckner V, Kovács J, Dénes G (1953) Structure of poly-D-glutamic acid isolated from capsulated strains of B. Anthracis. Nature 172: 508-508. 
  • Dickerson RE, Geis I (1969) The Structure and Action of Proteins pp 16-19. Harper & Row Publishers, New York.
  • Fox SW, Melius P, Nakashima T (1977) N-Terminal pyroglutamyl residues in proteins and thermal peptides. Matsubara H, Yamanaka T, eds. Proc. of the Symp. on Evolution of Protein Molecules, pp 111-120. Japan Scientific Societies Press.
  • Harada K (1959) Thermal homopolymerization of lysine and copolymerization with neutral and acidic amino acids. Bull Chem Soc Japan 32: 1007-1008.
  • Harada K, Fox SW (1965) Characterization of thermal polymers of neutral α-amino acids with dicarboxylic amino acids or lysine. Arch Biochem Biophys 109: 49-56. 
  • Harada K, Matsuyama M, Kokufuta E (1978) The aqueous thermal polycondensation of asparagines and isoasparagine and the structure of polyaspartic acid. Polymer Bull 1: 177-180.
  • Hartmann J, Brand MC, Dose K (1981) Formation of specific amino acid sequences during thermal polymerization of amino acids. BioSystems 13: 141-147. 
  • Katime IA (1994) Química Física Macromolecular, pp 190-191. Servicio Editorial, Universidad del País Vasco, Bilbao (Spain).
  • Kovács J, Nagy H (1961) Polypeptide formation from asparagine under hypothetically primitive conditions. Nature 190: 531-532. 
  • Kovács J, Kovacs HN, Könyves I, Császár J, Vajda T, Mix, H. (1961) Chemical studies of polyaspartic acids. J Org Chem 261: 1084-1091.
  • Meggy AB (1956) Glycine peptides. Part II. The heat and entropy of formation of the peptide bond in polyglycine. J Chem Soc 1444-1454.
  • Moran PAP (1984) An Introduction to Probability Theory, pp 108-111. Clarendon Press, Oxford.
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2000) A simple model of the thermal prebiotic oligomerization of amino acids. BioSystems 57: 67-73. 
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2002) Biased polymers in the origin of life. Biosystems 65: 99-103. 
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2008) Prebiotic thermal polymerization of crystals of amino acids via the diketopiperazine reaction. BioSystems 91: 195-200. 
  • Munegumi T, Tanikawa N, Mita H, Harada K (1994) Peptide formation by heating aqueous solution containing asparagine. Viva Origino 22: 111-125.
  • Nakashima T, Jungck JR, Fox SW, Lederer E, Das BC (1977) A Test for Randomness in Peptides Isolated from a Thermal Polyamino Acid. Int J Quant Chem Quant Biol Symp 4: 65-72.
  • Oro J, Guidry CL (1961) Direct synthesis of polypeptides 1. Polycondensation of glycine in aqueous ammonia. Arch Biochem Biophys 93: 166-171. 
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Typ dokumentu
Bibliografia
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