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2012 | 59 | 4 |
Tytuł artykułu

Biased versus unbiased randomness in homo-polymers and copolymers of amino acids in the prebiotic world

Warianty tytułu
Języki publikacji
EN
Abstrakty
EN
 The polymerization of amino acids under anhydrous prebiotic conditions was first studied several decades ago. Here we use a stochastic model stressing the relevant role of the polarity of amino acids in the formation of oligopeptides in a prebiotic milieu. Our goal is to outline the predominance of co-polypeptides over homo-polypeptides, resulting not only from the randomness, but also from polarity properties of amino acids. Our results conclude that there was a higher probability of the formation of co-polypeptides than of homo-polymers. Besides, we may hypothesize that the former would have a more ample spectrum of possible chemical functions than homo-polypeptides.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
59
Numer
4
Opis fizyczny
p.543-547,fig.,ref.
Twórcy
  • Direccion General de Divulgacion de la Ciencia, Universidad Nacional Autonoma de Mexico, Mexico
autor
  • Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de México, Mexico
autor
  • Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de México, Mexico
autor
  • Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de México, Mexico
  • Centro de Investigaciones Químicas, Universidad Autónoma del Estado de Morelos, Cuernavaca, Morelos, Mexico
  • Subdireccion de Epidemiologia Hospitalaria y Control de Calidad de la Atencion Medica, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, México
Bibliografia
  • Bruckner V, Kovács J, Dénes G (1953) Structure of poly-D-glutamic acid isolated from capsulated strains of B. Anthracis. Nature 172: 508-508. 
  • Dickerson RE, Geis I (1969) The Structure and Action of Proteins pp 16-19. Harper & Row Publishers, New York.
  • Fox SW, Melius P, Nakashima T (1977) N-Terminal pyroglutamyl residues in proteins and thermal peptides. Matsubara H, Yamanaka T, eds. Proc. of the Symp. on Evolution of Protein Molecules, pp 111-120. Japan Scientific Societies Press.
  • Harada K (1959) Thermal homopolymerization of lysine and copolymerization with neutral and acidic amino acids. Bull Chem Soc Japan 32: 1007-1008.
  • Harada K, Fox SW (1965) Characterization of thermal polymers of neutral α-amino acids with dicarboxylic amino acids or lysine. Arch Biochem Biophys 109: 49-56. 
  • Harada K, Matsuyama M, Kokufuta E (1978) The aqueous thermal polycondensation of asparagines and isoasparagine and the structure of polyaspartic acid. Polymer Bull 1: 177-180.
  • Hartmann J, Brand MC, Dose K (1981) Formation of specific amino acid sequences during thermal polymerization of amino acids. BioSystems 13: 141-147. 
  • Katime IA (1994) Química Física Macromolecular, pp 190-191. Servicio Editorial, Universidad del País Vasco, Bilbao (Spain).
  • Kovács J, Nagy H (1961) Polypeptide formation from asparagine under hypothetically primitive conditions. Nature 190: 531-532. 
  • Kovács J, Kovacs HN, Könyves I, Császár J, Vajda T, Mix, H. (1961) Chemical studies of polyaspartic acids. J Org Chem 261: 1084-1091.
  • Meggy AB (1956) Glycine peptides. Part II. The heat and entropy of formation of the peptide bond in polyglycine. J Chem Soc 1444-1454.
  • Moran PAP (1984) An Introduction to Probability Theory, pp 108-111. Clarendon Press, Oxford.
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2000) A simple model of the thermal prebiotic oligomerization of amino acids. BioSystems 57: 67-73. 
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2002) Biased polymers in the origin of life. Biosystems 65: 99-103. 
  • Mosqueira FG, Ramos-Bernal S, Negron-Mendoza A (2008) Prebiotic thermal polymerization of crystals of amino acids via the diketopiperazine reaction. BioSystems 91: 195-200. 
  • Munegumi T, Tanikawa N, Mita H, Harada K (1994) Peptide formation by heating aqueous solution containing asparagine. Viva Origino 22: 111-125.
  • Nakashima T, Jungck JR, Fox SW, Lederer E, Das BC (1977) A Test for Randomness in Peptides Isolated from a Thermal Polyamino Acid. Int J Quant Chem Quant Biol Symp 4: 65-72.
  • Oro J, Guidry CL (1961) Direct synthesis of polypeptides 1. Polycondensation of glycine in aqueous ammonia. Arch Biochem Biophys 93: 166-171. 
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Typ dokumentu
Bibliografia
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