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2012 | 30 | 1 |
Tytuł artykułu

Polymorphism in coding and regulatory sequences of beta-casein gene is associated with milk production traits in Holstein-Friesian cattle

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EN
Abstrakty
EN
Beta-casein gene (CSN2) is considered a marker of milk production traits in dairy cattle. Allele A2, the most common in Holstein-Friesian breed, is beneficial for milk protein yield. However, within CSN2 other mutations occur which could potentially be involved in shaping the variation of milk production traits. In this study a new SNP (C/T) was found located within a regulatory sequence of CSN2 (position -1578), called enhancer which is thought to play an important role in the amount of the beta-casein mRNA produced. The aim of the study was to verify effects of both SNPs on milk production traits in Polish Holstein-Friesian (HF) dairy cattle. Six-hundred-and-fifty bulls were genotyped with two methods, PCR-ACRS (Amplification-Created Restriction Site, Mph1103 I) and PCR-RFLP (EcoR I), for the A1/A2 polymorphism and the C/T SNP polymorphism (BCE129), respectively. Although both SNPs are located close to each other, their allele frequencies were found significantly different (0.33, 0.67, 0.89 and 0.11 for the A1, A2, C and T, respectively). A mixed linear model was used for testing the association between these polymorphisms and deregressed breeding values for production traits. The analysis revealed that the allele coding the A2 protein variant increases breeding values for milk and milk protein yields while allele C of BCE129 increases the milk fat yield.
Słowa kluczowe
Wydawca
-
Rocznik
Tom
30
Numer
1
Opis fizyczny
p.5-12,fig.,ref.
Twórcy
autor
  • Department of Animal Genetics, University of Warmia and Mazury in Olsztyn, 10-718 Olsztyn, Poland
autor
autor
autor
Bibliografia
  • Freyer G., Liu Z., Erhardt G., Panicke L., 1999 – Casein polymorphism and relation between milk production traits. Journal of Animal Breeding and Genetics 116, 87-97.
  • Ikonen T., Bovenh UIS H., Ojala M., Ruottinen O., Georges M., 2001 –Associations between casein haplotypes and first lactation milk production traits in Finnish Ayrshire cows. Journal of Dairy Science 84, 507-514.
  • Ikonen T., Ojala M., Ruottinen O., 1999 – Associations between milk protein polymorphism and first lactation milk production traits in Finnish Ayrshire cows. Journal of Dairy Science 82,1026-1033.
  • Kearney J.F., Amer P.R., Villanueva B., 2005 – Cumulative discounted expressions of sire genotypes for the Complex Vertebral Malformation and β-casein loci in commercial dairy herds.Journal of Dairy Science 88, 4426-4433.
  • Khatkar M.S., Thomson P.C., Tammen I., Raadsma H.W., 2003 – Quantitative trait loci mapping in dairy cattle: review and meta-analysis. Genetics, Selection, Evolution 36, 163-190.
  • Lipkin E., Tal -Stein R., Friedman A., Soller M., 2008 – Effect of Quantitative Trait Loci for milk protein percentage on milk protein yield and milk yield in Israeli Holstein dairy cattle. Journal of Dairy Science 91, 1614-1627.
  • Myers C.A., Schmidhauser C., Mellentin -Michelotti J., Fragoso G.,Roskelley C.D., Casperson G., Mossi R., Pujuguet P., Hager G., Bissell M.J.,1998 – Characterization of BCE-1, a transcriptional enhancer regulated by prolactin and extracellular matrix and modulated by the state of histone acetylation. Molecular and Cellular Biology 18(4),2184-2195.
  • Nilsen H., Olsen H.G., Hayes B., Sehested E., Svendson M., Nome T., Meuwissen T., Lien S., 2009 – Casein haplotypes and their associations with milk production traits in Norwegian Red cattle. Genetics Selection Evolution 41, 1-12.
  • R Development Core Team , 2010 – R: A language and environment for statistical computing.R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.Rproject. org.
  • Roginski H., 2003 – Encyclopedia of dairy sciences. Academic Press, London, UK.
  • Schopen G.C., Koks P.D., van Arendonk J.A., Bovenh UIS H., Visker M.H., 2009 – Whole genome scan to detect quantitative trait loci for bovine milk protein composition. Animal Genetics 40(4), 524-537.
  • Szyda J., Liu Z., Reinardt F., Reents R., 2005 – Estimation of Quantitative Trait Loci parameters for milk production traits in German Holstein dairy cattle population. Journal of Dairy Science 88, 356-367.
  • WARNES G.R., 2003 - The Genetics Package. RNews 3(1), 9-13.
  • Winkelman A.M., Wickham B.W., 1997 – Associations between milk protein genetic variants and production traits in New Zealand dairy cattle. Proceedings of IDF Seminar “Milk Protein Polymorphism”, Palmerston North, New Zealand, pages 38-46. Publisher – International Dairy Federation.
  • Velmala R., Vilkki J., Elo K., Maki -Tanila A., 1995 – Casein haplotypes and their association with milk production traits in the Finnish Ayrshire cattle. Animal Genetics 26(6), 419-425
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