The possibilities of practical application of transgenic mammalian species generated by somatic cell cloning in pharmacology, veterinary medicine and xenotransplantology

• Autorzy: Samiec M. , Skrzyszowska M.
• Języki publikacji: EN

Abstrakty

EN

Cloning of genetically-modified mammals to produce: 1) novel animal bioreactors expressing human genes in rens, urinary bladder and the male accessory sex glands, as well as 2) porcine organs suitable in pig-to-human xenotransplantology, could offer new advantages for biomedical purposes. So too does the generation and/or multiplication of genetically-engineered cloned animals in order to produce: 3) physiologically-relevant animal models of serious monogenic human diseases and 4) prion disease-resistant small as well as large animals (i.e., rodents, ruminants). The basic purpose of this paper is to overview current knowledge deciphering the possibilities of using transgenic specimens created by somatic cell nuclear transfer in medical pharmacology, veterinary medicine, agriculture, transplantational medicine and immunology.

Słowa kluczowe

EN

practical application; transgenic mammal; somatic cell; cell cloning; pharmacology; veterinary medicine; xenotransplantation

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2011
• Tom: 14
• Numer: 2
• Opis fizyczny: p.329-340,fig.,ref

Twórcy

autor

Samiec M.

• Department of Biotechnology and Animal Reproduction, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice n.Krakow, Poland

autor

Skrzyszowska M.

• Department of Biotechnology and Animal Reproduction, National Research Institute of Animal Production, Krakowska 1, 32-083 Balice n.Krakow, Poland

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