Nicorandil attenuates neuronal mitochondrial dysfunction and oxidative stress associated with murine model of vascular calcification

• Autorzy: Ravindran S. , Swaminathan K. , Ramesh A. , Kurian G.A.
• Języki publikacji: EN

Abstrakty

EN

Evidences suggest that the presence of chronic kidney disease (CKD) is associated with cerebrovascular diseases related cognitive decline in dialysis patients. As mitochondrial dysfunction is implicated in neurodegenerative disorders, we hypothesized that changes in brain mitochondria occur due to vascular calcification induced by renal failure and the opening of the mitochondrial potassium channel using nicorandil may prevent its dysfunction. Brain tissues from rats with vascular calcification were studied. Nicorandil (7.5 mg/kg b.wt.) was given either concomitantly or after the induction of calcification. The brain tissues were evaluated for antioxidant capacity, mitochondrial enzymes and oxidative phosphorylation efficiency along with the progression of calcification. The results suggested that renal failure, elevated the calcium, phosphorus product in the brain. The brain cytoplasm and mitochondrial fractions showed an elevated TBARS and a corresponding decline in the antioxidant enzymes, indicating a severe oxidative stress. The elevated brain mitochondrial enzymes like NADH dehydrogenase, and succinate dehydrogenase in the disease control groups, reversed to the near control level after nicorandil treatment. We observed that nicorandil was more effective when given after calcification. It reduced the biochemical alterations associated with calcium and phosphorous toxicity in the brain, by preserving mitochondria, the key target for treating neurodegenerative diseases.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2017
• Tom: 77
• Numer: 1
• Opis fizyczny: p.57-67,fig.,ref.

Twórcy

autor

Ravindran S.

• Vascular Biology Lab, SASTRA University, Thanjavur, India

autor

Swaminathan K.

• School of Chemical and Biotechnology, SASTRA University, Thanjavur, India

autor

Ramesh A.

• School of Chemical and Biotechnology, SASTRA University, Thanjavur, India

autor

Kurian G.A.

• Vascular Biology Lab, SASTRA University, Thanjavur, India

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