Stany zapalne macicy u krów mlecznych – diagnostyka i leczenie

• Autorzy: Brodzki P.

Warianty tytułu

EN

Uterine inflammatory conditions in dairy cows: Diagnosis and treatment

• Języki publikacji: PL

Abstrakty

EN

The diagnosis of inflammatory conditions in the uterus depends primarily on the severity of the inflammation process and associated clinical symptoms. Because of the period of occurrence and characteristic signs, severe lesions in the uterus, such as metritis puerperalis, are not difficult to diagnose and do not require the use of diagnostic methods other than clinical examinations and, if necessary, additional tests to determine the general condition of the animals. However, in this case, it is important to precisely identify the pathogenic factor and to determine its susceptibility to antibiotics in order to define further treatment. Endometritis is the biggest diagnostic problem, especially its subclinical form, which can be diagnosed only by additional cytological or histopathological tests. These tests, although available, are not routinely performed in Poland at this time. The latest diagnostic methods, such as immunohistochemical tests or flow cytometry, have provided many previously unknown data, for example, on the action of the local resistance mechanisms in the uterus. Since the immune system of the uterus is not fully known, the above tests may improve the understanding of its activity or may help modulate its functions in the future as a potential preventative measure or treatment for inflammatory conditions of the uterus. The treatment of inflammatory conditions in dairy cows is currently based on two basic methods: intrauterine administration of antibiotics and intramuscular injections of prostaglandin-based preparations. The main goal of the treatment is to improve the fertility of cows in the herd, and since these methods are often ineffective, there have been attempts to treat endometritis with iodine-based preparations and preparations containing enzymes (trypsin, chymotrypsin and papain). They did not, however, improve the fertility of cows. The administration of non-steroid anti-inflammatory drugs to eliminate the inflammatory condition of the uterus and to prevent early deaths of embryos at the time of the greatest risk of embryo loss did not increase the number of pregnancies in cows either. Literature data suggest that immunomodulation and the use of probiotics may be useful in the prevention and treatment of endometritis.

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2020
• Tom: 76
• Numer: 05
• Opis fizyczny: s.266-272,bibliogr.

Twórcy

autor

Brodzki P.

• Katedra i Klinika Rozrodu Zwierząt, Wydział Medycyny Weterynaryjnej, Uniwersytet Przyrodniczy w Lublinie, ul. Głęboka 30, 20-612 Lublin

Bibliografia

• 1. Barański W., Kaleczyc J., Zduńczyk S., Podlasz W., Długołęcka-Malinowska E., Janowski T.: Distribution of CD14+ macrophages, CD4+, CD8+ lymphocytes and mRNA expression of inducible nitritic oxide synthase in the endometrium of repeat breeding cows. Polish. J. Vet. Sci. 2013, 3, 443-451.
• 2. Barlund C. S., Carruthers T. D., Waldner C. L., Palmer C. W.: A comparison of diagnostic techniques for postpartum endometritis in dairy cattle. Theriogenology 2008, 69, 714-723.
• 3. Benzaquen M. E., Risco C. A., Archbald L. F., Melendez P., Thatcher M. J., Thatcher W. W.: Rectal temperature, calving-related factors, and the incidence of puerperal metritis in postpartum dairy cows. J. Dairy Sci. 2007, 90, 2804--2814.
• 4. Brodzki P., Brodzki A., Kostro K., Kurek Ł., Marczuk J., Krakowski L.: Cytological image of the endometrium in cows in follicular and luteal phases of the ovarian cycle and in cows with follicular and luteal ovarian cysts. Bull. Vet. Inst. Pulawy 2014, 58, 141-147.
• 5. Brodzki P., Brodzki A., Kurek Ł., Marczuk J., Tatara M. R.: Endometrial cytology at luteal and follicular phases of the ovarian cycle in cows. Ann. Anim. Sci. 2015, 15, 107-117.
• 6. Brodzki P., Kostro K., Brodzki A., Lisiecka U.: Determination of selected parameters for non-specific and specific immunity in cows with subclinical endometritis. Anim. Reprod. Sci. 2014, 148, 109-114.
• 7. Brodzki P., Kostro K., Brodzki A., Lisiecka U., Kurek Ł., Marczuk J.: Phenotyping of leukocytes and granulocyte and monocyte phagocytic activity in the peripheral blond and uterus of cows with endometritis. Theriogenology 2014, 82, 403-410.
• 8. Brodzki P., Lisiecka U., Brodzki A., Pyz-Łukasik R., Krakowski L.: Phagocytic and oxidative burst activity of phagocytic cells in peripheral blood and uterine washings in cows with clinical endometritis before and after intrauterine use of cephapirin and methisoprinol. Anim. Sci. J. 2018, 89, 1389-1397.
• 9. Brodzki P., Niemczuk K., Kostro K., Brodzki A., Kurek Ł., Marczuk J.: Cytological evaluation of inflammation of the uterus and influence of endometritis on selected reproductive parameters in dairy cows. Bull. Vet. Inst. Pulawy 2014, 58, 235-242.
• 10. Couto G. B., Vaillantcourt D. H., Lefebvre R. C.: Comparison of a leukocyte esterase with endometrial cytology for diagnosis of subclinical endometritis in postpartum dairy cows. Theriogenology 2013, 79, 103-107.
• 11. Dhaliwal G. S., Murray R. D., Woldehiwet Z.: Some aspects of immunology of the bovine uterus related to treatments for endometritis. Anim. Reprod. Sci. 2001, 67, 135-152.
• 12. Drillich M., Raab D., Wittke M., Heuwieser W.: Treatment of chronic endometritis in dairy cows with an intrauterine application of enzymes: A field trial. Theriogenology 2005, 63, 1811-1823.
• 13. Drillich M., Voigt D., Forderung D., Heuwieser W.: Treatment of acute puerperal metritis with flunixin meglumine in addition to antibiotic treatment. J. Dairy Sci. 2007, 90, 3758-3763.
• 14. Dubuc J., Duffield T. F., Leslie K. E., Walton J. S., LeBlanc S. J.: Definitions and diagnosis of postpartum endometritis in dairy cows. J. Dairy Sci. 2010, 93, 5225-5233.
• 15. Dubuc J., Duffield T. F., Leslie K. E., Walton J. S., Leblanc S. J.: Effects of postpartum uterine diseases on milk production and culling in dairy cows. J. Dairy Sci. 2011, 94, 1339-1346.
• 16. Erdem H., Guzeloglu A.: Effect of meloxicam treatment during early pegnancy in holstein heifers. Reprod. Dom. Anim. 2010, 45, 625-628.
• 17. Etherington W. G., Martin S. W., Bonnett B. N.: Reproductive performance of dairy cows following treatment with cloprostenol 26 and/or 40 days postpartum: A field trial. Theriogenology 1988, 29, 565-275.
• 18. Földi J., Kulcsár M., Pécsia A., Huyghe B., de Sa C., Lohuis J. A., Cox P., Huszenicza G.: Bacterial complications of postpartum uterine involution in catle. Anim. Reprod. Sci. 2006, 96, 265-281.
• 19. Galvão K. N.: Postpartum uterine diseases in dairy cows. Anim. Reprod. 2012, 9, 290-296.
• 20. Galvão K. N., Frajblat M., Brittin S. B., Butler W. R., Guard C. L., Gilbert R. O.: Effect of prostaglandin F2 alpha on subclinical endometritis and fertility in dairy cows. J. Dairy Sci. 2009, 92, 4906-4913.
• 21. Galvão K. N., Greco L. F., Vilela J. M., Sa Filho M. F., Santos J. E.: Effect of intrauterine infusion of Ceftiofur on uterine health and fertility in dairy cows. J. Dairy Sci. 2009, 92, 1532-1542.
• 22. Gautam G., Nako T., Koike K., Long S. T., Yusuf M., Ranasinghe R. M., Hayashi A.: Spontaneous recovery or persistence of postpartum endometritis and risk factors for its persistence in Holstein cows. Theriogenology 2010, 152, 411-416.
• 23. Gilbert R. O., Shin Sang T., Guard C. L., Hollis E. N., Frajblat M.: Prevalence of endometritis and its effects on reproductive performance of dairy cows. Theriogenology 2005, 64, 1879-1888.
• 24. Heuwieser W., Iwersen M., Goetze L.: Efficacy of carprofen on conception rates in lactating dairy cows after subcutaneous or intrauterine administration at the time of breeding. J. Dairy Sci. 2011, 94, 146-151.
• 25. Haimerl P., Hauwieser W., Arlt S.: Therapy of bovine endometritis with prostaglandin F2α: A meta-analysis. J. Dairy Sci. 2013, 96, 2973-2987.
• 26. Kaczmarowski M., Malinowski E., Markiewicz H.: Bacteria isolated from the uterus of cows with foetal membrane retained. Bull. Vet. Inst. Pulawy 2004, 48, 33-36.
• 27. Kaczmarowski M., Malinowski E., Markiewicz H.: Influence of various treatment methods on bacteriological findings in cows with puerperal metritis. Polish J. Vet. Sci. 2004, 7, 171-174.
• 28. Kaneko K., Takagi N.: The effect of dinoprost treatment on Trueperella pyogenes in uterus of cows with pyometra. International J. Anim. Vet. Adv. 2013, 5, 202-205.
• 29. Kasimanickam R., Duffield T. F., Foster R. A., Gartley C. J., Leslie K. E., Walton J. S., Johnson W. H.: A comparison of the cytobrush and uterine lavage techniques to evaluate endometrial cytology in clinically normal postpartum dairy cows. Can. Vet. J. 2005, 46, 255-259.
• 30. Kasimanickam R., Duffield T. F., Foster R. A., Gartley C. J., Leslie K. E., Walton J. S., Johnson W. H.: Endometrial cytology and ultrasonography for the detection of subclinical endometritis in postpartum dairy cows. Theriogenology 2004, 62, 9-23.
• 31. Kasimanickam R., Duffield T. F., Foster R. A., Gartley C. J., Leslie K. E., Walton J. S., Johnson W. H.: The effect of a single administration of cephapirin or cloprostenol on the reproductive performance of dairy cows with subclinical endometritis. Theriogenology 2005, 63, 818-830.
• 32. Kimura K., Goff J. P., Kehrli M. E. Jr., Harp J. A.: Phenotype analysis of peripherial blood mononuclear cells in periparturient dairy cows. J. Dairy Sci. 1999, 82, 315-319.
• 33. Knutti B., Kupfer U., Busato A.: Reproductive efficiency of cows with endometritis after treatment with intrauterine infusions or prostaglandin injections, or no treatment. J. Vet. Med. A. 2000, 47, 609-615.
• 34. LeBlanc S. J.: Postpartum uterine disease and dairy herd reproductive performance: A review. Vet. J. 2008, 176, 102-114.
• 35. LeBlanc S. J., Duffield T. F., Leslie K. E., Bateman K. G., Keefe G. P., Walton J. S., Johnson W. H.: The effect of treatment of clinical endometritis on reproductive performance in dairy cows. J. Dairy Sci. 2002, 85, 2237-2249.
• 36. Malinowski E., Lassa H., Markiewicz H., Kaptur M., Nadolny M., Niewitecki W., Ziętara J.: Sensitivity to antibiotics of Arcanobacterium pyogenes and Escherichia coli from the uteri of cows with metritis/endometritis. Vet. J. 2011, 187, 234-238.
• 37. Mateus L., Lopes da Costa L., Bernardo F., Robalo Silva J.: Influence of puerperal uterine infection on uterine involution and postpartum ovarian activity in dairy cows. Reprod. Dom. Anim. 2002, 37, 31-35.
• 38. Mateus L., Lopes da Costa L., Carvalho H., Serra P., Robalo Silva J.: Blod and Intrauterine leukocyte profile and function in dairy cows that spontaneously recovered from postpartum endometritis. Reprod. Dom. Anim. 2002, 37, 176--180.
• 39. Miller R. H., Paape M. J., Filep R., Link S.: Flow cytometric analysis of neutrophils in cows milk. Am. J. Vet. Res. 1993, 54, 1975-1979.
• 40. Moges N., Regassa F., Yilma T., Unakal Ch. G.: Isolation and antimicrobial susceptibility of bacteria from dairy cows with clnical endometritis. J. Reprod. Inferti. 2013, 4, 04-08.
• 41. Nakao T., Moriyoshi M., Kawata K.: Effect of postpartum intrauterine treatment with 2% polyvinyl-pyrrolidone-iodine solution on reproductive efficiency in cows. Theriogenology 1988, 30, 1033-1043.
• 42. Paisley L. G., Mickelson W. D., Anderson P. B.: Mechanism and therapy for retained fetal membranes and uterine infection of cows: A review. Theriogenology 1986, 25, 353-381.
• 43. Pascottini O. B., Hostens M., Dini P., Van Eetvelde M., Vercauteren P., Opsomer G.: Prevalence of cytological endometritis and effect on pregnancy outcomes at the time of insemination in nulliparous dairy heifers. J. Dairy Sci. 2016, 99, 9051-9056.
• 44. Potter T. J., Guitian J., Fishwick O. J. G., Sheldon M.: Risk factors for clinical endometritis in postpartum dairy cattle. Theriogenology 2010, 74, 127-134.
• 45. Prieto M., Barrio M., Quintela L. A., Perez-Martin C. C., Becerra J. J., Vigo M., Diaz C., Cainzos J., Prieto A., Fernandez F. I., Martinez D., Herradon P. G.: Validation of simple method for the interpretation of uterine cytology in cows. Vet. Med. 2012, 57, 360-363.
• 46. Sannmann I., Burfeind O., Voigtsberger R., Heuwieser W.: Comparison of two monitoring and treatment strategies for cows with acute puerperal metritis. Theriogenology 2013, 79, 961-969.
• 47. Santos T. M., Gilbert R. O., Bicalho R. C.: Metagenomic analysis of the uterine bacterial microbiota in healthy and metritic postpartum dairy cows. J. Dairy Sci. 2011, 94, 291-302.
• 48. Singh J., Sidhu S. S., Dahliwal G. S., Pangaonkar G. R., Nanda A. S., Grewal A. S.: Effectiveness of lipopolysaccharide as an intrauterine immunomodulator in curing bacterial endometritis in repeat breeding cross-bred cows. Anim. Reprod. Sci. 2000, 59, 159-166.
• 49. Sheldon I. M.: The postpartum uterus. Vet. Clin. Food. Anim. 2004, 20, 569-591.
• 50. Sheldon I. M., Cronin J., Goetze L., Donofrio G., Schuberth H. J.: Defining postpartum uterine disease and the mechanism of infection and immunity in the female reproductive tract in Cattle. Biol. Reprod. 2009, 81, 1025-1032.
• 51. Sheldon I. M., Dobson H.: Postpartum uterine health in cattle. Anim. Reprod. Sci. 2004, 82-83, 295-306.
• 52. Sheldon I. M., Lewis G. S., LeBlanc S., Gilbert R. O.: Defining postpartum uterine disease in cattle. Theriogenology 2006, 65, 1516-1530.
• 53. Szczuka E., Makowska N., Kaznowski A.: Molekularne metody identyfikacji bakterii z rodzaju staphylococcus. Post. Mikrobiol. 2013, 52, 211-218.
• 54. Szenci O.: Diagnosis and treatment of post partum uterine abnormalities in the cow. Lucrări Stiintifice. 2010, 53, 3-8.
• 55. Trevisi E., Bertoni G.: Attenuation of acetylsalicylate treatments of inflammatory conditions in periparturient dairy cows. P. I. Quinn, ed. Nova Science Publishers, New York. 2008, 23-37.
• 56. Turner M. L., Healer G. D., Sheldon I. M.: Immunity and inflammation in the uterus. Reprod. Dom. Anim. 2012, 47, 402-409.

Identyfikatory

DOI

10.21521/mw.6359