Age-related macular degeneration (AMD):Alzheimer’s disease in the eye?

• Autorzy: Kaarniranta K.
• Języki publikacji: EN

Abstrakty

EN

Alzheimer´s disease (AD) and age-related macular degeneration (AMD) are the most common age-related neurodegenerative diseases in the western countries. They share similar environmental risk factors, comprising of smoking, hypertension, hypercholesterolemia, atherosclerosis, obesity, and unhealthy diet. In both diseases, cellular pathology is associated with increased oxidative stress, inflammation, and impaired proteolysis that evoke formation of intra- and extracellular deposits; plaques in AD and drusen in AMD. Autophagy is a lysosomal catabolic clearance mechanism that is triggered as an adaptive response during AD- and AMD-associated stress conditions. Autophagy dysfunction is currently discussed as an important factor in the development of neurodegenerative diseases. Failure of autophagy in aged post mitotic cells, including neurons or retinal pigment epithelial cells (RPE), can result in accumulation of aggregate-prone proteins, cellular degeneration and finally cell death. Since both diseases have different genetic background, but have similar environmental risk factors and cellular pathology we believe that impaired autophagy is a key player in the pathogenesis of these diseases.

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2015
• Tom: 75
• Numer: Supl.
• Opis fizyczny: p.S32

Twórcy

autor

Kaarniranta K.

• Group of Immuno-Ophthalmology, Department of Ophthalmology, University of Eastern Finland, Kuopio, Finland
• Kuopio University Hospital, Kuopio, Finland