Preferencje help
Widoczny [Schowaj] Abstrakt
Liczba wyników
2013 | 62 | 4 |

Tytuł artykułu

Carriage of group B streptococci in pregnant women from the region of Krakow and their antibiotic resistance in the year 2008–2012

Warianty tytułu

Języki publikacji



The aim of the study was a retrospective analysis of the frequency of group B streptococci (Streptococcus agalactaie; GBS) carriage in pregnant women from the region of Krakow, together with an analysis of their drug resistance, carried out between 2008-2012. The study included 3363 pregnant women between 35 and 37 weeks of gestation, studied in accordance with the guidelines of the Polish Gynecological Society (2008). A high percentage of pregnant women who are carriers of group B streptococci was demonstrated. Each year covered by the study, it was in the range of 25-30%, with an average value equal to 28%. The results confirm the need for taking swabs from both the vagina and anus, since 15% of GBS-positive patients showed only rectal carriage. High percentage of isolates resistant to erythromycin was detected, which ranged from 22% to 29%, with an average value equal to 25%, as well as a high proportion of isolates resistant to clindamycin being 17-25%, with an average of 20%. The results indicate the need to standardize the methodology of collecting samples for GBS testing and introduce microbiological diagnostic standards in all gynecological and obstetric centers in Poland, in order to carry out a detailed epidemiological analysis in our country.








Opis fizyczny



  • Chair of Microbiology, Department of Bacteriology, Microbial Ecology and Parasitology, Jagiellonian University Medical College, Czysta Street 18, 31-121 Krakow, Poland
  • Jagiellonian University Medical College, Krakow, Poland
  • Jagiellonian University Medical College, Krakow, Poland


  • Acikgoz Z.C., E. Almayanlar, S. Gamberzade and S. Gocer. 2004. Macrolide resistance determinants of invasive and noninvasive group B streptococci in a Turkish hospital. Antimicrob. Agents. Chemother. 48: 1410-1412.
  • Bayó M., M. Berlanga and M. Agut. 2002. Vaginal microbiota in healthy pregnant women and prenatal screening of group B streptococci (GBS). Int. Microbiol. 5: 87-90.
  • Brimil N., E. Barthell, U. Heindrchs, M. Kuhn, R. Lütticken and B. Spellerberg. 2006. Epidemiology of Streptococcus agalactiae colonization in Germany. Int. J. Med. Microbiol. 296: 39-44.
  • Brzychczy-Włoch M., T. Gosiewski, M. Bodaszewska-Lubas, P. Adamski and P.B. Heczko. 2012. Molecular characterization of capsular polysaccharides and surface protein genes in relation to genetic similarity of group B streptococci isolated from Polish pregnant women. Epidemiol. Infect. 140: 329-336.
  • Colbur T. and R. Gilbert. 2007. An overview of the natural history of early onset group B streptococcal disease in the UK. Early. Hum. Dev. 83: 149-156.
  • Dadvand P., X. Basagana, F. Figueras, J. Sunyer and M.J. Nieuwenhuijsen. 2011. Climate and group B streptococci colonization during pregnancy: present implications and future concerns. BJOG. 118: 1396-1400.
  • De Mouy D., J.D. Cavallo, R. Ledercq, R. Fabre and The Aforcopi-Bio Network. 2001. Antibiotic susceptibility and mechanisms of erythromycin resistance in clinical isolates of Streptococcus agalactiae: French multicenter study. Antimicrob. Agents. Chemother. 45: 2400-2402.
  • EUCAST - European Committee on Antimicrobial Susceptibility Testing. Version 2.0, valid from 2012-01-01. fileadmin/src/media/PDFs/EUCAST_files/Disk_test_document/ EUC AST_breakpoints_v_2.0_l 20101 .pdf.
  • Gherardi G., M. Imperi, L. Baldassarri, G. Gherardi, M. Imperi, L. Baldassarri, M. Pataracchia, G. Alfarone, S. Recchia, G. Orefici, G. Dicuonzo and R. Creti. 2007. Molecular epidemiology and distribution of serotypes, surface proteins, and antibiotic resistance among group B streptococci in Italy. J. Clin. Microbiol. 45:2909-2916.
  • Hansen S.M., N. Uldbjerg, M. Kilian and U.B. Sorensen. 2004. Dynamics of Streptococcus agalactiae colonization in women during and after pregnancy and in their infants. J. Clin. Microbiol. 42: 83-89.
  • Kimura K., S. Suzuki, J. Wachino, H. Kurokawa, K. Yamane, N. Shibata, N. Nagano, H. Kato, K. Shibayama and Y. Arakawa. 2008. First molecular characterization of group B streptococci with reduced penicillin susceptibility. Antimicrob. Agents. Chemother. 52: 2890-2897.
  • Kociszewska-Najman B., A. Oslislo, I. Szymusik, B. Pietrzak and Z. Jabiry-Zieniewicz. 2010. Intrapartum prophylaxis against group B Streptococcus infection-own experience. Ginekol. Pol. 81: 913-917.
  • Kotarski J., PB. Heczko, R. Lauterbach, T. Niemiec and B. Leszczenska-Zgorzelak. 2008. Polish Gynecological Society Recommendations for the detection of carriers of group B streptococci (GBS) in pregnant women and the prevention of infections in newborns. Ginekol. Pol. 79: 221-223.
  • Krasnianin E., J. Skret-Magierlo, J. Witalis, E. Barnas, T. Kluz, A. Koziel and A. Skret. 2008. The incidence of Streptococcus Group B in 100 parturient women and the transmission of pathogens to the newborn. Ginekol. Pol. 80: 285-289.
  • Ma Y.Y., T.Y. Hsu, S.Y. Shen, Y.Y. Ma, T.Y. Hsu, S.Y. Shen, T.S. Huang, J.S. Mob, CM. Liu, CY. Ou and others. 2012. Epidemiology of group B Streptococcus ST-17 clone in pregnant women of South Taiwan. Gynecol. Obstet. Invest. 73: 285-293.
  • Motlova J., L. Strakova, P. Urbásková, P. Sak and T. Sever. 2004. Vaginal and rectal carriage of Streptococcus agalactiae in the Czech Republic: incidence, serotypes distribution and susceptibility to antibiotics. Indian. J. Med. Res. 119: 84-87.
  • Rodriguez-Granger J., J.C. Alvargonzalez, A. Berardi, R. Berner, M. Kunze, M. Hufnagel, P. Melin, A. Decheva, G. Orefici, C. Poyart C and others. 2012. Prevention of group B streptococcal neonatal disease revisited. The DEVANI European project. Eur. J. Clin. Microbiol. Infect. Dis. 31: 2097-2104.
  • Romanik M., K. Nowosielski, G. Martirosian, R. Poreba and U. Sioma-Markowska. 2011. Identification of pregnant women at risk of Streptococcus group B colonisation. Neuro. Endocrinol. Lett. 32: 308-312.
  • The regulation of the Polish Minister of Health from 23rd September 2010. Annex to the Regulation - Standards and procedures for the award of medical health services in the field of perinatal care exercised over women during physiological pregnancy, physiological childbirth, puerperium and infant care (in Polish).
  • Schoening T.E., J. Wagner and M. Arvand. 2005. Prevalence of erythromycin and clindamycin resistance among Streptococcus agalactiae isolates in Germany. Clin. Microbiol. Infect. 11: 579-582.
  • Schrag S., R. Gorwitz, K. Fultz-Butts and A. Schuchat. 2002. Prevention of perinatal group B streptococcal disease. Revised guidelines from CDC. MMWR. 15: 1-22.
  • Serafin M., M. Prosniewska and J. Kalinka. 2010. Group B streptococci (GBS) prevalence in pregnant women in Lodz region: an obstetrical approach and neonatal complications. Arch. Perinat. Med. 16: 194-197.
  • Strus M., D. Pawlik, M. Brzychczy-Wloch, T. Gosiewski, K. Rytlewski, K. Lauterbach and P.B. Heczko. 2009. Group B Streptococcus colonization of pregnant women and their children observed on obstetric and neonatal wards of the University Hospital in Krakow, Poland. J. Med. Microbiol. 58: 228-233.
  • Stupak A., A. Kwasniewska, M. Semczuk, G. Zdzienicka and A. Malm. 2010. The colonization of women genital tract by Streptococcus agalactiae. Arch. Perinat. Med. 16: 48-50.
  • Tsolia M., M. Psoma, S. Gavrili, V. Petrochilou, S. Michalas, N. Legakis and T. Karpathios. 2003. Group B Streptococcus colonization of Greek pregnant women and neonates: prevalence, risk factors and serotypes. Clin. Microbiol. Infect. 9: 832-838.
  • Uh Y., H.Y. Kim, LH. Jang, G.Y. Hwang and K.Y. Yoon. 2005. Correlation of serotypes and genotypes of macrolide-resistant Streptococcus agalactiae. Yonsei. Med. J. 46: 480-483.
  • Verani J., L. McGee and S.J. Schrag. 2010. Prevention of perinatal group B Streptococcal Disease. Revised Guidelines from CDC. MMWR. 59: 1-32.

Typ dokumentu



Identyfikator YADDA

JavaScript jest wyłączony w Twojej przeglądarce internetowej. Włącz go, a następnie odśwież stronę, aby móc w pełni z niej korzystać.