The influence of 8-prenylnaringenin on the activity of voltage-gated kv1.3 potassium channels in human jurkat T cells

• Autorzy: Gasiorowska J. , Teisseyre A. , Uryga A. , Michalak K.
• Języki publikacji: EN

Abstrakty

EN

Using the whole-cell patch-clamp technique, we investigated the influence of 8-prenylnaringenin on the activity of the voltage-gated Kv1.3 potassium channels in the human leukemic T lymphocyte cell line Jurkat. 8-prenylnaringenin is a potent plant-derived phytoestrogen that has been found to inhibit cancer cell proliferation. The results show that it inhibited the Kv1.3 channels in a concentration-dependent manner. Complete inhibition occurred at concentrations higher than 10 μM. The inhibitory effect of 8-prenylnaringenin was reversible. It was accompanied by a significant acceleration of channel inactivation without any pronounced change in the activation rate. Of the naringenin derivatives tested to date, 8-prenylnaringenin is the most potent inhibitor of the Kv1.3 channels. The potency of the inhibition may be due to the presence of a prenyl group in the molecule of this flavonoid. The inhibition of the Kv1.3 channels might be involved in the antiproliferative and pro-apoptotic effects of 8-prenylnaringenin that have been observed in cancer cell lines expressing these channels.

Słowa kluczowe

EN

8-prenylnaringenin; voltage-gated potassium channel; potassium channel; man; jurkat T cell; T cell; jurkat T lymphocyte; T lymphocyte; patch clamp; cancer cell; proliferation; apoptosis

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2012
• Tom: 17
• Numer: 4
• Opis fizyczny: p.559-570,fig.,ref.

Twórcy

autor

Gasiorowska J.

• Department of Biophysics, Wroclaw Medical University, Chalubinskiego 10, 50-368 Wroclaw, Poland

autor

Teisseyre A.

autor

Uryga A.

autor

Michalak K.

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